DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31871 and LIPK

DIOPT Version :9

Sequence 1:	NP_723607.1	Gene:	CG31871 / 34463	FlyBaseID:	FBgn0051871	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	XP_011538375.1	Gene:	LIPK / 643414	HGNCID:	23444	Length:	419	Species:	Homo sapiens

Alignment Length:	371	Identity:	128/371 - (34%)
Similarity:	218/371 - (58%)	Gaps:	23/371 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 DASLITPKLIRKYGYPSETHTVVTKDGYILEMHRIPKKGAQP--------VLLMHGILDTSATWV 130
            :|::...::|..:|||.|.:.|.|||||||.::|||.....|        |.|.||::.:::.|:
Human    50 EANMNISQIISYWGYPYEEYDVTTKDGYILGIYRIPHGRGCPGRTAPKPAVYLQHGLIASASNWI 114

  Fly   131 LMGPKSGLGYMLSDLGYDVWMGNSRGNRYSKNHTSLNSDYQEFWDFTFHEMGKYDLPANIDYILS 195
            ...|.:.|.::|:|.|||||:||||||.:|:.|..|:....|:|.|:..||.||||||.|::|:.
Human   115 CNLPNNSLAFLLADSGYDVWLGNSRGNTWSRKHLKLSPKSPEYWAFSLDEMAKYDLPATINFIIE 179

  Fly   196 KTGYEQVHYIGHSQGTAIFWVLCSEQPAYTQKITSMHALAPIAYIHDMKSPLFRTLVLFLDFLTA 260
            |||.::::|:||||||.|.::..|..|...:||....||||:..:...:||:.:       ..|.
Human   180 KTGQKRLYYVGHSQGTTIAFIAFSTNPELAKKIKIFFALAPVVTVKYTQSPMKK-------LTTL 237

  Fly   261 ATRMLRI----TEFMPNTKFLVDHSQVVCHDNAMTQDVCSNILFLVAGYNSEQLNKTMLPVMLSH 321
            :.|::::    ..|.|:|.|....:..|| :..:.:.:|||.||.::|::.:.||.:.|.|.|||
Human   238 SRRVVKVLFGDKMFHPHTLFDQFIATKVC-NRKLFRRICSNFLFTLSGFDPQNLNMSRLDVYLSH 301

  Fly   322 TPSGASIKQLEHFGQLMKSGHFRKFDRGYL-RNQLEYNRMTPPDYDLSRVKVPVALYYSVNDLLV 385
            .|:|.|::.:.|:.|.:.||..:.||.|.. :|.:.::::|||.|::::::||.|::....|::.
Human   302 NPAGTSVQNMLHWAQAVNSGQLQAFDWGNSDQNMMHFHQLTPPLYNITKMEVPTAIWNGGQDIVA 366

  Fly   386 STTGVDRLARELPNVIDKYLVPMERFNHLDFLWAIDVKPLVYNRLV 431
            ....|:.|..::.|:|...|:|  .:||:||....|....:|..|:
Human   367 DPKDVENLLPQIANLIYYKLIP--HYNHVDFYLGEDAPQEIYQDLI 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31871	NP_723607.1	Abhydro_lipase	79..133	CDD:282003	22/61 (36%)
		MhpC	93..436	CDD:223669	122/352 (35%)
		Abhydrolase_5	115..281	CDD:289465	64/177 (36%)
LIPK	XP_011538375.1	PLN02872	31..410	CDD:215470	127/369 (34%)
		Abhydro_lipase	55..117	CDD:282003	22/61 (36%)
		Abhydrolase_5	99..>246	CDD:289465	59/153 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141847
Domainoid	1	1.000	222	1.000	Domainoid score	I2592
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	271	1.000	Inparanoid score	I3005
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	1	1.000	-	-		mtm8502
orthoMCL	1	0.900	-	-		OOG6_100408
Panther	1	1.100	-	-	O	PTHR11005
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1506
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.840