DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31871 and LIPJ

DIOPT Version :9

Sequence 1:	NP_723607.1	Gene:	CG31871 / 34463	FlyBaseID:	FBgn0051871	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_001010939.2	Gene:	LIPJ / 142910	HGNCID:	21773	Length:	366	Species:	Homo sapiens

Alignment Length:	361	Identity:	134/361 - (37%)
Similarity:	211/361 - (58%)	Gaps:	16/361 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 KLIRKYGYPSETHTVVTKDGYILEMHRIP-------KKGAQPVL--LMHGILDTSATWVLMGPKS 136
            ::|..:|||.|.:.:||:|||||.::|||       |..||.|:  |.||:|.::::|:...|.:
Human     5 QIISYWGYPDEEYDIVTEDGYILGLYRIPYWRTDNNKNLAQRVVVYLQHGLLTSASSWISNLPNN 69

  Fly   137 GLGYMLSDLGYDVWMGNSRGNRYSKNHTSLNSDYQEFWDFTFHEMGKYDLPANIDYILSKTGYEQ 201
            .||::|:|.||||||||||||.:|:.|..|.:..:|||.|:|.||.||||||:||:.:.:|..|:
Human    70 SLGFILADAGYDVWMGNSRGNTWSRKHLYLETSSKEFWAFSFDEMAKYDLPASIDFTVKQTRQEE 134

  Fly   202 VHYIGHSQGTAIFWVLCSEQPAYTQKITSMHALAPIAYIHDMKSPLFRTLVLFLDFLTAATRMLR 266
            :.|:||||||.|.::..|......::|....||||:.....:||||.|....:...:.|.:..
Human   135 IFYVGHSQGTTIGFITFSTISKIAERIKIFFALAPVFSTKYLKSPLIRMTYKWKSIVMAFSGN-- 197

  Fly   267 ITEFMPNTKFLVDHSQVVCHDNAMTQDVCSNILFLVAGYNSEQLNKTMLPVMLSHTPSGASIKQL 331
             .:|:|.|.|.......:| ...:...:|.||||::.||:.:.||.:.|.|..||.|:|.|::.:
Human   198 -KDFLPKTSFKKFIGSKLC-PLQIFDKICLNILFMMFGYDPKNLNMSRLDVYFSHNPAGTSVQNM 260

  Fly   332 EHFGQLMKSGHFRKFDRGYL-RNQLEYNRMTPPDYDLSRVKVPVALYYSVNDLLVSTTGVDRLAR 395
            .|:.||:.|.|.:.:|.|.. .|.:.||:.|.|.|:::.:.|..|::...:|||.....|:.|..
Human   261 LHWSQLLNSTHLKAYDWGSPDLNLVHYNQTTSPLYNMTNMNVATAIWNGKSDLLADPEDVNILHS 325

  Fly   396 ELPNVIDKYLVPMERFNHLDFLWAIDVKPLVYNRLV 431
            |:.|.|  |...:..:||:|.|:.:||...||:.::
Human   326 EITNHI--YYKTISYYNHIDSLFGLDVYDQVYHEII 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31871	NP_723607.1	Abhydro_lipase	79..133	CDD:282003	24/60 (40%)
		MhpC	93..436	CDD:223669	129/349 (37%)
		Abhydrolase_5	115..281	CDD:289465	67/167 (40%)
LIPJ	NP_001010939.2	Abhydro_lipase	3..66	CDD:282003	24/60 (40%)
		Abhydrolase_5	47..209	CDD:289465	67/164 (41%)
		Abhydrolase_1	48..347	CDD:278959	111/304 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141827
Domainoid	1	1.000	222	1.000	Domainoid score	I2592
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	271	1.000	Inparanoid score	I3005
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	1	1.000	-	-		mtm8502
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11005
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.910