DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31871 and Lipo2

DIOPT Version :9

Sequence 1:	NP_723607.1	Gene:	CG31871 / 34463	FlyBaseID:	FBgn0051871	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_001309267.1	Gene:	Lipo2 / 101055671	MGIID:	3644466	Length:	398	Species:	Mus musculus

Alignment Length:	437	Identity:	148/437 - (33%)
Similarity:	225/437 - (51%)	Gaps:	60/437 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LLHCLVALEVCGRAGAFTLLSPFSYSSLSFKNLLNSVLLSSNPNLAGGGRNLKSDVLEDASLITP 80
            ||..:..::|.|:  .|.|..|                 ..||               :|.:...
Mouse     4 LLRTMCLIQVLGK--IFCLFGP-----------------KKNP---------------EAHMNVS 34

  Fly    81 KLIRKYGYPSETHTVVTKDGYILEMHRIP-----KKGAQP---VLLMHGILDTSATWVLMGPKSG 137
            ::|:.:.||||.:.|||.|||||.::|||     .|...|   |...||:|.|...||...|.:.
Mouse    35 EIIKHWDYPSEEYEVVTDDGYILPINRIPHGKNNAKSPAPKMVVFCQHGLLATPGAWVSNPPVNS 99

  Fly   138 LGYMLSDLGYDVWMGNSRGNRYSKNHTSLNSDYQEFWDFTFHEMGKYDLPANIDYILSKTGYEQV 202
            |.::|:|.|||||||:|||:.::|.|.:||.|.:|||||:|.:|.||||||.|::||.|||.:|:
Mouse   100 LAFILADAGYDVWMGSSRGSTWAKKHVTLNPDSKEFWDFSFDQMIKYDLPATINFILDKTGQKQI 164

  Fly   203 HYIGHSQGTAIFWVLCSEQPAYTQKITSMHALAPIAYIHDMKSPLFRTLVLFLDFLTAATRMLRI 267
            :||||||||.:.....:......:||.....||||..:...|.     :.....:||..|..|..
Mouse   165 YYIGHSQGTLLAIGAFATNQKLAEKIKLNILLAPIYSVQHSKG-----ISHLASYLTPTTIKLLF 224

  Fly   268 --TEFMPNTKFLVDHSQV---VCHDNAMTQDVCSNILFLVAGYNSEQLNKTMLPVMLSHTPSGAS 327
              .||:|...|    |:|   ||:.|..|. :|:.|:..:.||:.|:|||:.|.|.:....:|.|
Mouse   225 GEKEFLPTVVF----SEVGACVCNINFFTA-ICAAIMGSMGGYSPEELNKSRLDVYVKLNLAGTS 284

  Fly   328 IKQLEHFGQLMKSGHFRKFDRGY-LRNQLEYNRMTPPDYDLSRVKVPVALYYSVNDLLVSTTGVD 391
            :|.|.|:.|:.:||..:.:|.|. ..|...||:.|||.|::..:|||.|::..:.|.|.....|:
Mouse   285 VKVLIHYNQVGRSGILQAYDWGSPSLNMRHYNQTTPPVYNVEDMKVPTAMFTGLKDFLSDPEDVE 349

  Fly   392 RLARELPNVIDKYLVPMERFNHLDFLWAIDVKPLVYNRLVRNVRRVE 438
            .|..::.|:  .||..:..|:|.||:|.::.:..|...::..:|:.:
Mouse   350 ILKPKIHNL--TYLKTIPDFSHFDFIWGLNTREEVSEEILTILRKYD 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31871	NP_723607.1	Abhydro_lipase	79..133	CDD:282003	25/61 (41%)
		MhpC	93..436	CDD:223669	132/356 (37%)
		Abhydrolase_5	115..281	CDD:289465	70/170 (41%)
Lipo2	NP_001309267.1	PLN02872	34..391	CDD:215470	137/368 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831878
Domainoid	1	1.000	227	1.000	Domainoid score	I2491
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	278	1.000	Inparanoid score	I2905
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	1	1.000	-	-		mtm8736
orthoMCL	1	0.900	-	-		OOG6_100408
Panther	1	1.100	-	-	O	PTHR11005
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.810