DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17097 and LIPF

DIOPT Version :9

Sequence 1:	NP_609429.1	Gene:	CG17097 / 34461	FlyBaseID:	FBgn0265264	Length:	1087	Species:	Drosophila melanogaster
Sequence 2:	NP_001185758.1	Gene:	LIPF / 8513	HGNCID:	6622	Length:	408	Species:	Homo sapiens

Alignment Length:	368	Identity:	125/368 - (33%)
Similarity:	206/368 - (55%)	Gaps:	25/368 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   729 LIEKYGYPSETNYVTSEDGYRLCLHRIP-------RPGAEPVL-LVHGLMASSASWVELGPKDGL 785
            :|..:|||:|...|.:||||.|.::|||       ..|..||: |.|||:||:.:|:...|.:.|
Human    48 MITYWGYPNEEYEVVTEDGYILEVNRIPYGKKNSGNTGQRPVVFLQHGLLASATNWISNLPNNSL 112

  Fly   786 AYILYRKGYDVWMLNTRGNIYSRENLNRRLKPNKYWDFSFHEIGKFDVPAAIDHILIHTHKPKIQ 850
            |:||...|||||:.|:|||.::|.||.......::|.|||.|:.|:|:||.||.|:..|.:.::.
Human   113 AFILADAGYDVWLGNSRGNTWARRNLYYSPDSVEFWAFSFDEMAKYDLPATIDFIVKKTGQKQLH 177

  Fly   851 YIGHSQGSTVFFVMCSERPNYAHKVNLMQALSPTVYLQENRSPV--LKFL--GMFKGKYSMLLNL 911
            |:|||||:|:.|:..|..|:.|.::....||:|...::..:|.:  |:|:  .:||        .
Human   178 YVGHSQGTTIGFIAFSTNPSLAKRIKTFYALAPVATVKYTKSLINKLRFVPQSLFK--------F 234

  Fly   912 LGGYEISAKTKLIQQF-RQHICSGSELGSSICAIFDFVLCGFDWKSFNTTLTPIVAAHASQGASA 975
            :.|.:|........|| ...:|| .|:.:.:|:...|::||||.|:|||:...:..:|...|.|.
Human   235 IFGDKIFYPHNFFDQFLATEVCS-REMLNLLCSNALFIICGFDSKNFNTSRLDVYLSHNPAGTSV 298

  Fly   976 KQIYHYAQLQGDLNFQRFDHGA-VLNRVRYESSEPPAYNLSQTTSKVVLHHGEGDWLGSTSDVIR 1039
            :.::|:.|......||.:|.|: |.||:.|:.|:||.||::.....:.:.:|..|.|....||..
Human   299 QNMFHWTQAVKSGKFQAYDWGSPVQNRMHYDQSQPPYYNVTAMNVPIAVWNGGKDLLADPQDVGL 363

  Fly  1040 LQERLPNLVESRKVNFEGFSHFDFTLSKDVRPLLYSHVLRHLS 1082
            |..:||||:..:::.|  ::|.||..:.|....:|:.::..:|
Human   364 LLPKLPNLIYHKEIPF--YNHLDFIWAMDAPQEVYNDIVSMIS 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17097	NP_609429.1	Abhydro_lipase	726..780	CDD:282003	24/58 (41%)
		MhpC	746..1061	CDD:223669	112/328 (34%)
		Abhydrolase_5	762..>899	CDD:289465	56/141 (40%)
LIPF	NP_001185758.1	PLN02872	14..400	CDD:215470	124/362 (34%)
		Abhydro_lipase	45..107	CDD:282003	24/58 (41%)
		Abhydrolase_5	88..>211	CDD:289465	52/122 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141802
Domainoid	1	1.000	222	1.000	Domainoid score	I2592
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11005
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.850