DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18284 and LIPN

DIOPT Version :9

Sequence 1:	NP_001285807.1	Gene:	CG18284 / 34460	FlyBaseID:	FBgn0043825	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	NP_001095939.1	Gene:	LIPN / 643418	HGNCID:	23452	Length:	398	Species:	Homo sapiens

Alignment Length:	394	Identity:	119/394 - (30%)
Similarity:	194/394 - (49%)	Gaps:	23/394 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 SCLQCQQASYQQFF-AEVDIQIDAKLETPKMISKYGHQVETHYAFTADGYKLCLHRIP------- 129
            :||.|...:...|. .|.::..:..:.|.::|...|:..|.:...|.|||.|.::|||
Human     9 TCLICGTLNAGGFLDLENEVNPEVWMNTSEIIIYNGYPSEEYEVTTEDGYILLVNRIPYGRTHAR 73

  Fly   130 RSGATPVL-LVHGLMASSATWVQFGPSQGLAYILSQSGYDVWMLNTRGNVYSEERLAGRESDKIF 193
            .:|..||: :.|.|.|.:|.|::...:..|.::|:.:||||||.|:|||.:|.......|:|:.|
Human    74 STGPRPVVYMQHALFADNAYWLENYANGSLGFLLADAGYDVWMGNSRGNTWSRRHKTLSETDEKF 138

  Fly   194 WDFSFHEIGQYDLPAAIDLILLQTKMPSIQYIGHSQGSTAFFVMCSERPEYAGKISLMQSLSPSV 258
            |.|||.|:.:||||..||.|:.:|....:.:||||.|:|..||..|..||.|.:|.:..:|.|::
Human   139 WAFSFDEMAKYDLPGVIDFIVNKTGQEKLYFIGHSLGTTIGFVAFSTMPELAQRIKMNFALGPTI 203

  Fly   259 YMEGTRSPALKFMKLFSGGFTMLLNLLGGHKISLKNKIVDMFRNHICTKLIPSRICAIFEFVVCG 323
               ..:.|...|.:.|....:::..:.|.....|::|...:....||...|...||:.|..:..|
Human   204 ---SFKYPTGIFTRFFLLPNSIIKAVFGTKGFFLEDKKTKIASTKICNNKILWLICSEFMSLWAG 265

  Fly   324 FNFNSFNMTLSPILEGHASQGSSAKQIYHFAQLQGNSAFQKYDYGLILNKIR-YQSIFPPLYNLS 387
            .|..:.|.:...:...||..|||...|.|..||..:..|:.||:|...:.:: |....||:|:|:
Human   266 SNKKNMNQSRMDVYMSHAPTGSSVHNILHIKQLYHSDEFRAYDWGNDADNMKHYNQSHPPIYDLT 330

  Fly   388 LALGKVALHRGDGDWLGSESDVLRLERDLPNCIENRNIRF----EGFSHFDFTISKDVRSLVYDR 448
            ......|:..|..|.|.:..||.|:   ||   :.:::.:    ..::||||....|....:|..
Human   331 AMKVPTAIWAGGHDVLVTPQDVARI---LP---QIKSLHYFKLLPDWNHFDFVWGLDAPQRMYSE 389

  Fly   449 VISL 452
            :|:|
Human   390 IIAL 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18284	NP_001285807.1	Abhydro_lipase	99..150	CDD:282003	19/58 (33%)
		PLN02872	101..450	CDD:215470	111/361 (31%)
		Abhydrolase_5	135..>250	CDD:289465	49/115 (43%)
LIPN	NP_001095939.1	Abhydro_lipase	36..97	CDD:282003	20/60 (33%)
		Abhydrolase_1	79..379	CDD:278959	97/308 (31%)
		Abhydrolase	106..>175	CDD:304388	32/68 (47%)
		Abhydrolase	<149..>234	CDD:304388	27/87 (31%)
		Abhydrolase_5	<322..374	CDD:289465	13/57 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141810
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	271	1.000	Inparanoid score	I3005
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11005
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.910