DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18284 and LIPK

DIOPT Version :9

Sequence 1:	NP_001285807.1	Gene:	CG18284 / 34460	FlyBaseID:	FBgn0043825	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	XP_011538375.1	Gene:	LIPK / 643414	HGNCID:	23444	Length:	419	Species:	Homo sapiens

Alignment Length:	369	Identity:	118/369 - (31%)
Similarity:	192/369 - (52%)	Gaps:	16/369 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 DAKLETPKMISKYGHQVETHYAFTADGYKLCLHRIPRSGATP--------VLLVHGLMASSATWV 150
            :|.:...::||.:|:..|.:...|.|||.|.::|||.....|        |.|.|||:||::.|:
Human    50 EANMNISQIISYWGYPYEEYDVTTKDGYILGIYRIPHGRGCPGRTAPKPAVYLQHGLIASASNWI 114

  Fly   151 QFGPSQGLAYILSQSGYDVWMLNTRGNVYSEERLAGRESDKIFWDFSFHEIGQYDLPAAIDLILL 215
            ...|:..||::|:.||||||:.|:|||.:|.:.|........:|.||..|:.:|||||.|:.|:.
Human   115 CNLPNNSLAFLLADSGYDVWLGNSRGNTWSRKHLKLSPKSPEYWAFSLDEMAKYDLPATINFIIE 179

  Fly   216 QTKMPSIQYIGHSQGSTAFFVMCSERPEYAGKISLMQSLSPSVYMEGTRSPALKFMKLFSGGFTM 280
            :|....:.|:|||||:|..|:..|..||.|.||.:..:|:|.|.::.|:||..|...|    ...
Human   180 KTGQKRLYYVGHSQGTTIAFIAFSTNPELAKKIKIFFALAPVVTVKYTQSPMKKLTTL----SRR 240

  Fly   281 LLNLLGGHKISLKNKIVDMF-RNHICTKLIPSRICAIFEFVVCGFNFNSFNMTLSPILEGHASQG 344
            ::.:|.|.|:...:.:.|.| ...:|.:.:..|||:.|.|.:.||:..:.||:...:...|...|
Human   241 VVKVLFGDKMFHPHTLFDQFIATKVCNRKLFRRICSNFLFTLSGFDPQNLNMSRLDVYLSHNPAG 305

  Fly   345 SSAKQIYHFAQLQGNSAFQKYDYG-LILNKIRYQSIFPPLYNLSLALGKVALHRGDGDWLGSESD 408
            :|.:.:.|:||...:...|.:|:| ...|.:.:..:.|||||::......|:..|..|.:....|
Human   306 TSVQNMLHWAQAVNSGQLQAFDWGNSDQNMMHFHQLTPPLYNITKMEVPTAIWNGGQDIVADPKD 370

  Fly   409 VLRLERDLPNCIENRNIRFEGFSHFDFTISKDVRSLVYDRVISL 452
            |..|...:.|.|..:.|  ..::|.||.:.:|....:|..:|.|
Human   371 VENLLPQIANLIYYKLI--PHYNHVDFYLGEDAPQEIYQDLIIL 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18284	NP_001285807.1	Abhydro_lipase	99..150	CDD:282003	20/58 (34%)
		PLN02872	101..450	CDD:215470	115/358 (32%)
		Abhydrolase_5	135..>250	CDD:289465	51/122 (42%)
LIPK	XP_011538375.1	PLN02872	31..410	CDD:215470	116/365 (32%)
		Abhydro_lipase	55..117	CDD:282003	21/61 (34%)
		Abhydrolase_5	99..>246	CDD:289465	58/150 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141840
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	271	1.000	Inparanoid score	I3005
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11005
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.910