DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18284 and LIPA

DIOPT Version :9

Sequence 1:	NP_001285807.1	Gene:	CG18284 / 34460	FlyBaseID:	FBgn0043825	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	NP_000226.2	Gene:	LIPA / 3988	HGNCID:	6617	Length:	399	Species:	Homo sapiens

Alignment Length:	368	Identity:	119/368 - (32%)
Similarity:	189/368 - (51%)	Gaps:	14/368 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 DAKLETPKMISKYGHQVETHYAFTADGYKLCLHRIPR-------SGATPVL-LVHGLMASSATWV 150
            :..:...::||.:|...|.:...|.|||.|||:|||.       .|..||: |.|||:|.|:.||
Human    32 ETNMNVSEIISYWGFPSEEYLVETEDGYILCLNRIPHGRKNHSDKGPKPVVFLQHGLLADSSNWV 96

  Fly   151 QFGPSQGLAYILSQSGYDVWMLNTRGNVYSEERLAGRESDKIFWDFSFHEIGQYDLPAAIDLILL 215
            ....:..|.:||:.:|:||||.|:|||.:|.:......|...||.||:.|:.:|||||:|:.||.
Human    97 TNLANSSLGFILADAGFDVWMGNSRGNTWSRKHKTLSVSQDEFWAFSYDEMAKYDLPASINFILN 161

  Fly   216 QTKMPSIQYIGHSQGSTAFFVMCSERPEYAGKISLMQSLSPSVYMEGTRSPALKFMKLFSGGFTM 280
            :|....:.|:|||||:|..|:..|:.||.|.:|.:..:|.|...:....||..|..:|..   .:
Human   162 KTGQEQVYYVGHSQGTTIGFIAFSQIPELAKRIKMFFALGPVASVAFCTSPMAKLGRLPD---HL 223

  Fly   281 LLNLLGGHKISLKNKIVDMFRNHICTKLIPSRICAIFEFVVCGFNFNSFNMTLSPILEGHASQGS 345
            :.:|.|..:...::..:.....|:||.:|...:|....|::||||..:.||:...:...|:..|:
Human   224 IKDLFGDKEFLPQSAFLKWLGTHVCTHVILKELCGNLCFLLCGFNERNLNMSRVDVYTTHSPAGT 288

  Fly   346 SAKQIYHFAQLQGNSAFQKYDYG-LILNKIRYQSIFPPLYNLSLALGKVALHRGDGDWLGSESDV 409
            |.:.:.|::|......||.:|:| ...|...|...:||.||:...|...|:..|..|||....||
Human   289 SVQNMLHWSQAVKFQKFQAFDWGSSAKNYFHYNQSYPPTYNVKDMLVPTAVWSGGHDWLADVYDV 353

  Fly   410 LRLERDLPNCIENRNIRFEGFSHFDFTISKDVRSLVYDRVISL 452
            ..|...:.|.:.:.:|  ..:.|.||....|....:|:::|:|
Human   354 NILLTQITNLVFHESI--PEWEHLDFIWGLDAPWRLYNKIINL 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18284	NP_001285807.1	Abhydro_lipase	99..150	CDD:282003	23/58 (40%)
		PLN02872	101..450	CDD:215470	117/357 (33%)
		Abhydrolase_5	135..>250	CDD:289465	51/115 (44%)
LIPA	NP_000226.2	PLN02872	38..396	CDD:215470	119/362 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141850
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	271	1.000	Inparanoid score	I3005
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11005
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.910