DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18284 and LIPJ

DIOPT Version :9

Sequence 1:	NP_001285807.1	Gene:	CG18284 / 34460	FlyBaseID:	FBgn0043825	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	NP_001010939.2	Gene:	LIPJ / 142910	HGNCID:	21773	Length:	366	Species:	Homo sapiens

Alignment Length:	377	Identity:	120/377 - (31%)
Similarity:	188/377 - (49%)	Gaps:	37/377 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 KMISKYGHQVETHYAFTADGYKLCLHRIP---------RSGATPVLLVHGLMASSATWVQFGPSQ 156
            ::||.:|:..|.:...|.|||.|.|:|||         .:....|.|.|||:.|:::|:...|:.
Human     5 QIISYWGYPDEEYDIVTEDGYILGLYRIPYWRTDNNKNLAQRVVVYLQHGLLTSASSWISNLPNN 69

  Fly   157 GLAYILSQSGYDVWMLNTRGNVYSEERLAGRESDKIFWDFSFHEIGQYDLPAAIDLILLQTKMPS 221
            .|.:||:.:||||||.|:|||.:|.:.|....|.|.||.|||.|:.:|||||:||..:.||:...
Human    70 SLGFILADAGYDVWMGNSRGNTWSRKHLYLETSSKEFWAFSFDEMAKYDLPASIDFTVKQTRQEE 134

  Fly   222 IQYIGHSQGSTAFFVMCSERPEYAGKISLMQSLSPSVYMEGTRSPALK-------FMKLFSGGFT 279
            |.|:|||||:|..|:..|...:.|.:|.:..:|:|....:..:||.::       .:..|||...
Human   135 IFYVGHSQGTTIGFITFSTISKIAERIKIFFALAPVFSTKYLKSPLIRMTYKWKSIVMAFSGNKD 199

  Fly   280 MLLNLLGGHKISLKNKIVDMFRNHICTKLIP----SRICAIFEFVVCGFNFNSFNMTLSPILEGH 340
            .|      .|.|        |:..|.:||.|    .:||....|::.|::..:.||:...:...|
Human   200 FL------PKTS--------FKKFIGSKLCPLQIFDKICLNILFMMFGYDPKNLNMSRLDVYFSH 250

  Fly   341 ASQGSSAKQIYHFAQLQGNSAFQKYDYGL-ILNKIRYQSIFPPLYNLSLALGKVALHRGDGDWLG 404
            ...|:|.:.:.|::||..::..:.||:|. .||.:.|.....||||::......|:..|..|.|.
Human   251 NPAGTSVQNMLHWSQLLNSTHLKAYDWGSPDLNLVHYNQTTSPLYNMTNMNVATAIWNGKSDLLA 315

  Fly   405 SESDVLRLERDLPNCIENRNIRFEGFSHFDFTISKDVRSLVYDRVISLCGSN 456
            ...||..|..::.|.|..:.|.:  ::|.|.....||...||..:|.:...|
Human   316 DPEDVNILHSEITNHIYYKTISY--YNHIDSLFGLDVYDQVYHEIIDIIQDN 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18284	NP_001285807.1	Abhydro_lipase	99..150	CDD:282003	19/57 (33%)
		PLN02872	101..450	CDD:215470	118/369 (32%)
		Abhydrolase_5	135..>250	CDD:289465	52/114 (46%)
LIPJ	NP_001010939.2	Abhydro_lipase	3..66	CDD:282003	20/60 (33%)
		Abhydrolase_5	47..209	CDD:289465	63/175 (36%)
		Abhydrolase_1	48..347	CDD:278959	101/314 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141820
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	271	1.000	Inparanoid score	I3005
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11005
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.910