DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31872 and LIPK

DIOPT Version :9

Sequence 1:	NP_001285806.1	Gene:	CG31872 / 34458	FlyBaseID:	FBgn0051872	Length:	1073	Species:	Drosophila melanogaster
Sequence 2:	XP_011538375.1	Gene:	LIPK / 643414	HGNCID:	23444	Length:	419	Species:	Homo sapiens

Alignment Length:	369	Identity:	120/369 - (32%)
Similarity:	194/369 - (52%)	Gaps:	16/369 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   711 DAKLDTPKMISKYGHQAETHYAFTADGYKLCLHRIPRSGATP--------VLLVHGLMASSDTWV 767
            :|.::..::||.:|:..|.:...|.|||.|.::|||.....|        |.|.|||:||:..|:
Human    50 EANMNISQIISYWGYPYEEYDVTTKDGYILGIYRIPHGRGCPGRTAPKPAVYLQHGLIASASNWI 114

  Fly   768 QFGPSQGLAYILSQSGYDVWMLNTRGNVYSEERLAGRESDKIFWDFSFHEIGQYDLPAAIDLILL 832
            ...|:..||::|:.||||||:.|:|||.:|.:.|........:|.||..|:.:|||||.|:.|:.
Human   115 CNLPNNSLAFLLADSGYDVWLGNSRGNTWSRKHLKLSPKSPEYWAFSLDEMAKYDLPATINFIIE 179

  Fly   833 QTKMPSIQYIGHSQGSTAFFVMCSERPEYAGKISLMQSLSPSVYMEGTRSPALKFMKVLQGGFTM 897
            :|....:.|:|||||:|..|:..|..||.|.||.:..:|:|.|.::.|:||    ||.|......
Human   180 KTGQKRLYYVGHSQGTTIAFIAFSTNPELAKKIKIFFALAPVVTVKYTQSP----MKKLTTLSRR 240

  Fly   898 LLNLLGGHKISLKNRIVDMF-RNHICNKLIPSRICAIFEFVVCGFNFNSFNMTLSPILEGHASQG 961
            ::.:|.|.|:...:.:.|.| ...:||:.:..|||:.|.|.:.||:..:.||:...:...|...|
Human   241 VVKVLFGDKMFHPHTLFDQFIATKVCNRKLFRRICSNFLFTLSGFDPQNLNMSRLDVYLSHNPAG 305

  Fly   962 SSAKQIYHFAQLQGNSAFQKYDYG-LILNKIRYQSIFPPLYNLSLALGKVALHRGDGDWLGSESD 1025
            :|.:.:.|:||...:...|.:|:| ...|.:.:..:.|||||::......|:..|..|.:....|
Human   306 TSVQNMLHWAQAVNSGQLQAFDWGNSDQNMMHFHQLTPPLYNITKMEVPTAIWNGGQDIVADPKD 370

  Fly  1026 VLRLERDLPNCIENRNIRFEGFSHFDFTISKDVRSLVYDRVIDL 1069
            |..|...:.|.|..:.|  ..::|.||.:.:|....:|..:|.|
Human   371 VENLLPQIANLIYYKLI--PHYNHVDFYLGEDAPQEIYQDLIIL 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31872	NP_001285806.1	Abhydro_lipase	716..767	CDD:282003	20/58 (34%)
CG31872	NP_001285806.1	Abhydrolase_5	752..>894	CDD:289465	60/149 (40%)
LIPK	XP_011538375.1	PLN02872	31..410	CDD:215470	118/365 (32%)
		Abhydro_lipase	55..117	CDD:282003	21/61 (34%)
		Abhydrolase_5	99..>246	CDD:289465	59/150 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141841
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11005
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.850