DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7329 and LIPN

DIOPT Version :9

Sequence 1:	NP_001260357.1	Gene:	CG7329 / 34457	FlyBaseID:	FBgn0032271	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	NP_001095939.1	Gene:	LIPN / 643418	HGNCID:	23452	Length:	398	Species:	Homo sapiens

Alignment Length:	397	Identity:	133/397 - (33%)
Similarity:	202/397 - (50%)	Gaps:	52/397 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 GGF--MENTYPASVIEDAHLNTIQLLEKYKHPAETHQVTTDDKYILTLHRI------AR-PGAKP 78
            |||  :||    .|..:..:||.:::....:|:|.::|||:|.|||.::||      || .|.:|
Human    19 GGFLDLEN----EVNPEVWMNTSEIIIYNGYPSEEYEVTTEDGYILLVNRIPYGRTHARSTGPRP 79

  Fly    79 VL-LVHGLEDTSSTWIVMGPESGLGYFLYANGYDVWMGNVRGNRYSKGHVKLNPNTDKSYWSFSW 142
            |: :.|.|...::.|:.......||:.|...||||||||.|||.:|:.|..|: .||:.:|:||:
Human    80 VVYMQHALFADNAYWLENYANGSLGFLLADAGYDVWMGNSRGNTWSRRHKTLS-ETDEKFWAFSF 143

  Fly   143 HEIGMYDLPAMIDGVLQKTGYQKLSYFGHSQGTTSFFVMASSRPEYNAKIHLMSALAPVAFMKHM 207
            .|:..||||.:||.::.|||.:||.:.|||.|||..||..|:.||...:|.:..||.|....|:.
Human   144 DEMAKYDLPGVIDFIVNKTGQEKLYFIGHSLGTTIGFVAFSTMPELAQRIKMNFALGPTISFKYP 208

  Fly   208 KAPLMGIARMGMNMFGDNFELFPHSEV---------FLNQCLSSAAMLKTC-MRFYWQI------ 256
                .||.        ..|.|.|:|.:         ||....:..|..|.| .:..|.|
Human   209 ----TGIF--------TRFFLLPNSIIKAVFGTKGFFLEDKKTKIASTKICNNKILWLICSEFMS 261

  Fly   257 --VGKNREEQNMTMFPVVLGHLPGGCNIKQALHYLQMQKSDRFCQYDY-ESKENQRLYGRSTPPD 318
              .|.|::..|.:...|.:.|.|.|.::...||..|:..||.|..||: ...:|.:.|.:|.||.
Human   262 LWAGSNKKNMNQSRMDVYMSHAPTGSSVHNILHIKQLYHSDEFRAYDWGNDADNMKHYNQSHPPI 326

  Fly   319 YRLERIKAPVALYYGSNDYLSAVEDVHRLAKVLPNVVENHLYR---KWNHMDMIWGISARRSIQP 380
            |.|..:|.|.|::.|.:|.|...:||   |::||.:...|.::   .|||.|.:||:.|.:.:..
Human   327 YDLTAMKVPTAIWAGGHDVLVTPQDV---ARILPQIKSLHYFKLLPDWNHFDFVWGLDAPQRMYS 388

  Fly   381 RILQVMQ 387
            .|:.:|:
Human   389 EIIALMK 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7329	NP_001260357.1	Abhydro_lipase	42..96	CDD:282003	20/61 (33%)
		Abhydrolase	73..239	CDD:304388	65/176 (37%)
		Abhydrolase_1	77..371	CDD:278959	106/316 (34%)
LIPN	NP_001095939.1	Abhydro_lipase	36..97	CDD:282003	20/60 (33%)
		Abhydrolase_1	79..379	CDD:278959	106/315 (34%)
		Abhydrolase	106..>175	CDD:304388	35/69 (51%)
		Abhydrolase	<149..>234	CDD:304388	33/96 (34%)
		Abhydrolase_5	<322..374	CDD:289465	19/54 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141816
Domainoid	1	1.000	222	1.000	Domainoid score	I2592
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	271	1.000	Inparanoid score	I3005
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	1	1.000	-	-		mtm8502
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11005
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.910