Protein Alignment SH3RF3 and B0303.7

DIOPT Version :9

• Sequence 1: NP_001092759.1
• Gene: SH3RF3 / 344558
• HGNCID: 24699
• Length: 882
• Species: Homo sapiens
• Sequence 2: NP_498918.3
• Gene: B0303.7 / 176220
• WormBaseID: WBGene00015128
• Length: 493
• Species: Caenorhabditis elegans
• Alignment Length: 457
• Identity: 104/457 - (22%)
• Similarity: 174/457 - (38%)
• Gaps: 124/457 - (27%)

Human   116 RLLDGIRQRP--RAGTSPG---GSPPARPIPGQSAAPTLAGGGGGAAGSTPGSPVFLSAAAGSTA 175
            |..|.:...|  |.|||||   ||..|  |..|.....: ||...::.|:..:|.:.|.:..|.:
 Worm   105 RKSDSVPPPPPHRGGTSPGKLSGSHSA--IRSQLENMHI-GGSVMSSNSSTATPSYQSNSTSSYS 166

Human   176 GSL----------RELATSRTAPAAKNPCLLPYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQ 230
            .|.          .:...|.:|||...    |||.|.:.|...:..::....||.:::.:|||.:
 Worm   167 SSAPVAPPPVPRHTQSIPSYSAPAIST----PYGIAKFDYAPTQSDEMGLRIGDTVLISKKVDAE 227

Human   231 WYHGELHG--TQGFLPASYIQCIQPLPHA----PPQ------------GKALYDFEMKDKDQDKD 277
            |::||...  |.|.:|:||:....||..|    ||:            ..|:||:...:...
 Worm   228 WFYGENQNQRTFGIVPSSYLDIKIPLKEAFTALPPRPAAPSGSSSGTYATAIYDYNSNEAGD--- 289

Human   278 CLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYVELNDSAKQLIEMDKPCPAAASSCNASLP 342
             |.|.....:.|..||:|.|.||....:.||||..:|:..:..:  :.|.:..|::|.|.:..:.
 Worm   290 -LNFAVGSQIMVTARVNEEWLEGECFGRSGIFPSQFVDCPNLYQ--VPMKQSAPSSAPSYSHPIT 351

Human   343 SDSGAVASVAPSPTLSSSGAVSAFQRRVDGKKNTKKRHSFTALSVTHRSSQAASHRHSMEISAPV 407
            ::||...:|..|....|  .|::..|..:|       ...|||.               :|.|..
 Worm   352 NNSGPKQTVTVSYDYDS--GVASDLRLFEG-------DVITALE---------------DIDAQW 392

Human   408 LISS-----------------SDPRAAARIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGE 455
            |::.                 ..|:.|...| :|.::||..               |:.|..:|:
 Worm   393 LLAECRGQQGMVPKTFLGPPYGSPKKAPSKG-IAEIACAFS---------------PKKAVATGD 441

Human   456 QGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKG--ASLRTGVSGVFPGN 518
                               |..:....|.:.:|:...::|...|.::||  .:.:|..:|:.|.|
 Worm   442 -------------------YHSEDPKHLYVTRGDHLLIVEDVDDYYYKGKLEAFKTLPAGILPKN 487

Human   519 YV 520
            .|
 Worm   488 IV 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SH3RF3	NP_001092759.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	18..42
		RING	56..98	CDD:238093
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	124..159		14/39 (36%)
		SH3_SH3RF3_1	197..250	CDD:212861	18/54 (33%)
		SH3_SH3RF3_2	260..314	CDD:212864	16/65 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	368..399		5/30 (17%)
		Interaction with RAC1. /evidence=ECO:0000269|PubMed:20696164	369..439		13/86 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	433..458		3/24 (13%)
		SH3_SH3RF3_3	467..523	CDD:212858	12/56 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	575..664
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	693..747
		SH3_SH3RF_C	827..881	CDD:212719
B0303.7	NP_498918.3	SH3	194..247	CDD:214620	17/52 (33%)
		SH3	275..326	CDD:302595	16/54 (30%)
		SH3	356..409	CDD:214620	12/76 (16%)
		SH3	432..490	CDD:214620	15/92 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161457397
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840