DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trim9 and TRIM5

DIOPT Version :9

Sequence 1:	NP_001188786.1	Gene:	Trim9 / 34453	FlyBaseID:	FBgn0051721	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_149023.2	Gene:	TRIM5 / 85363	HGNCID:	16276	Length:	493	Species:	Homo sapiens

Alignment Length:	617	Identity:	128/617 - (20%)
Similarity:	202/617 - (32%)	Gaps:	189/617 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 LTCPLCRKLVFFDDGGVRNLPTYRAMEAIVDRFCAREALRCQMCETDPKVASLI------CEQCE 218
            :|||:|.:|:              .....:|  |....  ||.|.|.....|::      |..|.
Human    13 VTCPICLELL--------------TQPLSLD--CGHSF--CQACLTANHKKSMLDKGESSCPVCR 59

  Fly   219 IRY-CDACRELTHPAR-GPLAKHTLVKPRGAAQQRESVCGEHEETLSQYCLSCKAPACGLCIGEL 281
            |.| .:..|...|.|. ....:...:.|.|   |:...|..|.|.|..:|.......|.||....
Human    60 ISYQPENIRPNRHVANIVEKLREVKLSPEG---QKVDHCARHGEKLLLFCQEDGKVICWLCERSQ 121

  Fly   282 RHQAHDVQSINVTCKAQKTELSHNLQQLSEKARSTTEF---IQRLKG------MSDKVTESCMEF 337
            .|:.|.........:..:.:|...|:.|.:|.:...|.   |:..|.      ..|| |....:|
Human   122 EHRGHHTFLTEEVAREYQVKLQAALEMLRQKQQEAEELEADIREEKASWKTQIQYDK-TNVLADF 185

  Fly   338 ERLVHAQCEALIQAIHDRREYLLEAIRMDKDTKIRILKDQQSNCTGKLQQTTGLIQFCIEALKET 402
            |:|         :.|.|..| ..|...::|:.: .|||...::.|..:|||        ::|:|
Human   186 EQL---------RDILDWEE-SNELQNLEKEEE-DILKSLTNSETEMVQQT--------QSLRE- 230

  Fly   403 DSAAFLQVGSMLINRVTNTDMTWHQEVTNAAPRVSPIVDLTLDDAALARAIDNLNFIQMRAVKDG 467
                   :.|.|.:|:..:.|...|.|                |..:.|. :|:...:.......
Human   231 -------LISDLEHRLQGSVMELLQGV----------------DGVIKRT-ENVTLKKPETFPKN 271

  Fly   468 DERCPAAPMTPTILP-----SDCSAENNSVTVAWQPPNHSFVEGYVLELDDGSGGEFREVYCGKE 527
            ..|...||....:|.     :|.......||||   ||:  :...|:..|.      |:|...|.
Human   272 QRRVFRAPDLKGMLEVFRELTDVRRYWVDVTVA---PNN--ISCAVISEDK------RQVSSPKP 325

  Fly   528 TICTVDGLHFNSMYNARVKAFNSAGEGEYSELIGLQTAEVAWFTFDPVLSGGAGSGLIFSKNNAT 592
            .|          :|.||...:.:                                   |...|..
Human   326 QI----------IYGARGTRYQT-----------------------------------FVNFNYC 345

  Fly   593 VSVEGWEHRVALGSVGFSRGVHYWEFTIDNYTADTDPAFGV-------ARIDVARNK-------- 642
            ..:        |||...:.|.||||..:...||   ...||       |..::.:|:
Human   346 TGI--------LGSQSITSGKHYWEVDVSKKTA---WILGVCAGFQPDAMCNIEKNENYQPKYGY 399

  Fly   643 -MLGKDEKSFAMYIDRQRSWFQHNSIHERRVE-----GGITTGSTIGVLLDLERHTLSFLVNEMP 701
             ::|.:|       ..:.|.||.:|.|...|.     ..|.....:||.||.|..|:||. |...
Human   400 WVIGLEE-------GVKCSAFQDSSFHTPSVPFIVPLSVIICPDRVGVFLDYEACTVSFF-NITN 456

  Fly   702 QGSVAFRDLYGVF----YPAVSINR-GVTLTM 728
            .|.:.::..:..|    :|.::..: ||.:|:
Human   457 HGFLIYKFSHCSFSQPVFPYLNPRKCGVPMTL 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trim9	NP_001188786.1	RING-HC_TRIM9_like_C-I	2..37	CDD:319490
		zf-B_box	250..291	CDD:306989	11/40 (28%)
		ClassIIa_HDAC_Gln-rich-N	298..420	CDD:330228	30/130 (23%)
		FN3	472..564	CDD:238020	19/96 (20%)
		SPRY_PRY_TRIM67_9	561..735	CDD:293947	40/194 (21%)
TRIM5	NP_149023.2	RING	14..59	CDD:238093	13/62 (21%)
		BBOX	90..130	CDD:197662	11/39 (28%)
		Required for interaction with GABARAP and for autophagy. /evidence=ECO:0000250\|UniProtKB:Q0PF16	185..198		6/22 (27%)
		SPRY_PRY_TRIM5	288..489	CDD:293994	56/276 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910