DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trim9 and TRIM46

DIOPT Version :9

Sequence 1:	NP_001188786.1	Gene:	Trim9 / 34453	FlyBaseID:	FBgn0051721	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	XP_011508304.1	Gene:	TRIM46 / 80128	HGNCID:	19019	Length:	788	Species:	Homo sapiens

Alignment Length:	804	Identity:	193/804 - (24%)
Similarity:	295/804 - (36%)	Gaps:	211/804 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEDELRCPTCKQLYANPVLLPCFHALCLGCALDIQTPYSPGSALPGAVNGAGAASAAGHNGLHGN 65
            ||.||.||.|:::|..|::|||.|.:|..||.::                      .|..|..|:
Human    56 MEKELLCPVCQEMYKQPLVLPCTHNVCQACAREV----------------------LGQQGYIGH 98

  Fly    66 GGGAGGGAAAPVTNPNGPGTRHSSHSSAASTASSNTGSESVTSDQDQSDKVSIFSEADSGVVCCS 130
            ||.       |.:.|..|       :|..||.|... |.......|:.|:
Human    99 GGD-------PSSEPTSP-------ASTPSTRSPRL-SRRTLPKPDRLDR--------------- 133

  Fly   131 NTSRPVSYAGTGLLPGVGNVVAPPGAAYCLTCPLCRKLVFFDDGGVRNLPTYRAMEAIVDRFCAR 195
                 :..:|.|..||.......| ......||.|:..|...:.|:..|.....:|.:|:|:  |
Human   134 -----LLKSGFGTYPGRKRGALHP-QVIMFPCPACQGDVELGERGLAGLFRNLTLERVVERY--R 190

  Fly   196 E------ALRCQMCETDPKVASLICEQCEIRYCDACRELTHPARGPLAKHTLVKPRGAAQQRESV 254
            :      |:.||:|:..|..|:..|.:|...:|:.|.:|.||.....|:|....|..:.:.:..:
Human   191 QSVSVGGAILCQLCKPPPLEATKGCTECRATFCNECFKLFHPWGTQKAQHEPTLPTLSFRPKGLM 255

  Fly   255 CGEHEETLSQYCLSCKAPACGLCIGELRHQAHDVQSINVTCKAQKTELSHNLQ------------ 307
            |.:|:|.::.||.:|:...|.||.....|..|.:..:....:|.|.:|:.:|.
Human   256 CPDHKEEVTHYCKTCQRLVCQLCRVRRTHSGHKITPVLSAYQALKDKLTKSLTYILGNQDTVQTQ 320

  Fly   308 --QLSEKARSTTEFIQRLKGMSDKVTESCMEFERLVHAQCEALIQAIHDRREYLLEAIRMDKDTK 370
              :|.|..|.|....|:.|          .|..:||    ..|...:.::|..||:||...:..:
Human   321 ICELEEAVRHTEVSGQQAK----------EEVSQLV----RGLGAVLEEKRASLLQAIEECQQER 371

  Fly   371 IRILKDQ-QSNCTGKLQQTTGLIQFCIEALKETDSAAFLQVGSMLINRVTNTDMTWHQEVTNAAP 434
            :..|..| |.:  ..|...:||:.:..|.|||||...|:|....|.||:.        ..|.|..
Human   372 LARLSAQIQEH--RSLLDGSGLVGYAQEVLKETDQPCFVQAAKQLHNRIA--------RATEALQ 426

  Fly   435 RVSPIVDLT-----LDDAALARAIDNLNFIQMRAVKDGDERCPAAPMTPTILPSDCSAENNSVTV 494
            ...|....:     ||.....:.:..|||:          |.|.||    ::.:..:...:.:.:
Human   427 TFRPAASSSFRHCQLDVGREMKLLTELNFL----------RVPEAP----VIDTQRTFAYDQIFL 477

  Fly   495 AWQPPNHS------FVEGYVLELDDGSG---GEFREVYCGKETICTVDGLHFNSMYNARVKAFNS 550
            .|:.|.||      .||....::....|   .:.||...|  |...::.....|:|..||:..|.
Human   478 CWRLPPHSPPAWHYTVEFRRTDVPAQPGPTRWQRREEVRG--TSALLENPDTGSVYVLRVRGCNK 540

  Fly   551 AGEGEYSELIGLQT--AEVAWFTFDPVLSGGAGSGLIFSKNNATV-SVEGWE------------H 600
            ||.|||||.:.|.|  |.|..|..|. ..|.:...|..||:...| ||.|..            |
Human   541 AGYGEYSEDVHLHTPPAPVLHFFLDS-RWGASRERLAISKDQRAVRSVPGLPLLLAADRLLTGCH 604

  Fly   601 ---RVALGSVGFSRGVHYWEFTIDNYTADTDPAFGVARIDVARNKMLGKDEKSFAMYIDRQRSWF 662
               .|.||.|..::|..||...:       |||..:.::.|.....|   ::||....|.....:
Human   605 LSVDVVLGDVAVTQGRSYWACAV-------DPASYLVKVGVGLESKL---QESFQGAPDVISPRY 659

  Fly   663 QHNSIHERRVE-----------------------------------GGITTGSTI------GVLL 686
            ..:|.|:...|                                   .|.|.|.|:      |:.|
Human   660 DPDSGHDSGAEDATVEASPPFAFLTIGMGKILLGSGASSNAGLTGRDGPTAGCTVPLPPRLGICL 724

  Fly   687 DLERHTLSFLVNEMPQGSVAFRDL 710
            |.||..:|||      .:|:||.|
Human   725 DYERGRVSFL------DAVSFRGL 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trim9	NP_001188786.1	RING-HC_TRIM9_like_C-I	2..37	CDD:319490	15/34 (44%)
		zf-B_box	250..291	CDD:306989	11/40 (28%)
		ClassIIa_HDAC_Gln-rich-N	298..420	CDD:330228	35/136 (26%)
		FN3	472..564	CDD:238020	27/100 (27%)
		SPRY_PRY_TRIM67_9	561..735	CDD:293947	49/209 (23%)
TRIM46	XP_011508304.1	RING	62..>92	CDD:238093	12/51 (24%)
		zf-B_box	251..292	CDD:279037	11/40 (28%)
		iSH2_PI3K_IA_R	299..424	CDD:304922	36/148 (24%)
		FN3	473..554	CDD:238020	24/82 (29%)
		SPRY_PRY_TRIM46	561..770	CDD:293952	45/199 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24099
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010