DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trim9 and mid2

DIOPT Version :9

Sequence 1:	NP_001188786.1	Gene:	Trim9 / 34453	FlyBaseID:	FBgn0051721	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	XP_009289348.1	Gene:	mid2 / 799891	ZFINID:	ZDB-GENE-090220-1	Length:	718	Species:	Danio rerio

Alignment Length:	791	Identity:	193/791 - (24%)
Similarity:	289/791 - (36%)	Gaps:	240/791 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEDELRCPTCKQLYANPVLLPCFHALCLGCALDIQTPYSPGSALPGAVNGAGAASAAGHNGLHGN 65
            :|.||.||.|.:|:.:|:||||.|:||..||
Zfish     4 LESELTCPICLELFEDPLLLPCAHSLCFNCA---------------------------------- 34

  Fly    66 GGGAGGGAAAPVTNPNGPGTRHSSHSSAASTASSNTGSESVTSDQDQSDKVSIFSEADSGVVCCS 130
                                    |....|..||....||:::.|
Zfish    35 ------------------------HRILVSHCSSTKPLESISAFQ-------------------- 55

  Fly   131 NTSRPVSYAGTGLLPGVGNVVAPPGAAYCLTCPLCRKLVFFDDGGVRNLPTYRAMEAIVDRF--- 192
                                           ||.||.::..:..|:..|.....::.|:|||
Zfish    56 -------------------------------CPTCRYVITLNQRGLEGLKRNVTLQNIIDRFQKA 89

  Fly   193 -----------------------CAR----------EALRCQMCETD-PKVASLICEQCEIRYCD 223
                                   .||          |.:.||.|:.: |:.|...|..||:.|||
Zfish    90 SVSGPNSPNESRRPRPYSATLGGSARGSPASSAMSLERVGCQFCDQEPPREAVKTCVTCEVSYCD 154

  Fly   224 ACRELTHPARGPLAKHTLVKPRGAAQQRESVCGEHE-ETLSQYCLSCKAPACGLC--IGELRHQA 285
            .|...|||.:.|...|.||:|...||.|...|.||| |.::.||:......|.||  :|  ||:.
Zfish   155 RCLRATHPNKKPFTSHRLVEPVADAQLRGLACLEHENEKVNMYCVVDDQLICALCKLVG--RHRE 217

  Fly   286 HDVQSIN------------------VTCKAQKTELSHNLQQLSEKARSTTEFIQR---LKGMSDK 329
            |.|.|::                  ...:|.||..:..|:      .:.|..::|   |:....|
Zfish   218 HQVTSLSDRFDKLKAFQVSPARVSEAVMEASKTSAAQTLE------NNLTNLVKRNSELENQMAK 276

  Fly   330 VTESCMEFE--------RLVHAQCEALIQAIHDRREYLLEAIRMDKDTKIRILKDQQSNCTGKLQ 386
            :.:.|.:.|        :||. :|:.|::.|..|::.:...|:..|..|:|.|..|.:||...|:
Zfish   277 LIQICQQVEVNTAMHEAKLVE-ECDELVEIIRQRKQVIAVKIKESKVMKLRKLAQQIANCRQCLE 340

  Fly   387 QTTGLIQFCIEALKETDSAAFLQVGSMLINRVTNTDMTWHQEVTNAAPRVSPIVDLTLDDAALAR 451
            :::.||.....:|||.|...|||....:..||.         :..|:.:|      .:.|..|..
Zfish   341 RSSALITQAEHSLKENDHTRFLQTARNVAERVA---------MATASSQV------LIPDVNLNE 390

  Fly   452 AIDN--LNFIQMRAVKDGDERCPAAPMTPTILPSDCSAENNSVTVAWQPPNHSFVEGYVLELDDG 514
            |.||  |:|.:.:.:.:|.:.. .||..|:|....|:|.::::||.|...:...|..|.|:....
Zfish   391 AFDNFALDFSREKKILEGLDYL-TAPNPPSIREELCTASHDTITVHWTSEDEFSVTSYELQYTIY 454

  Fly   515 SG-GEFREVYCG----------KETICTVDGLHFNSMYNARVKAFNSAGEGEYSELIGLQTAEVA 568
            :| ..|..:|..          |:...||.||...:.|...|||.|.|| ...||...|:|....
Zfish   455 TGQTNFISLYNSVDSWMIVPNIKQNHYTVHGLQSGTRYIFFVKAINQAG-SRNSEPARLKTNSQP 518

  Fly   569 WFTFDPV-------LSGGAGSGLIFSKNNATVSVEGWEHRV-------ALGSVGFSRGVHYWEFT 619
             |..||.       ||...   |...|:.:::.......|.       |.|:|....|.||||..
Zfish   519 -FKLDPKTAHKKLRLSNDC---LTMEKDESSLKKSHTPERFSGTGSYGAAGNVFIDSGCHYWEVL 579

  Fly   620 IDNYTADTDPAFGVARIDVARNKMLGKDEKSFAMYIDRQRSWFQHNSIHERRVEGGITTGSTIGV 684
            :.   |.|..|.|||.....:|:..||:..|:...........:||: .|..||..:.. ..:||
Zfish   580 LG---ASTWYALGVAYKSAPKNEWSGKNSSSWVFSRCNNNFLVRHNN-KESIVEASLQL-RRVGV 639

  Fly   685 LLDLERHTLSF 695
            |||.:.:||||
Zfish   640 LLDYDNNTLSF 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trim9	NP_001188786.1	RING-HC_TRIM9_like_C-I	2..37	CDD:319490	17/34 (50%)
		zf-B_box	250..291	CDD:306989	16/43 (37%)
		ClassIIa_HDAC_Gln-rich-N	298..420	CDD:330228	35/132 (27%)
		FN3	472..564	CDD:238020	30/102 (29%)
		SPRY_PRY_TRIM67_9	561..735	CDD:293947	42/149 (28%)
mid2	XP_009289348.1	RAD18	4..>139	CDD:333230	40/243 (16%)
		RING-HC_MID1	8..61	CDD:319667	25/161 (16%)
		RING-HC finger (C3HC4-type)	10..59	CDD:319667	23/157 (15%)
		BBOX	126..163	CDD:197662	15/36 (42%)
		BBOX	186..223	CDD:237988	15/38 (39%)
		BBC	254..377	CDD:128778	33/138 (24%)
		FN3	415..504	CDD:214495	26/89 (29%)
		SPRY_PRY_TRIM1	519..688	CDD:293974	40/140 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24099
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010