DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trim9 and FSD1

DIOPT Version :9

Sequence 1:	NP_001188786.1	Gene:	Trim9 / 34453	FlyBaseID:	FBgn0051721	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_077309.1	Gene:	FSD1 / 79187	HGNCID:	13745	Length:	496	Species:	Homo sapiens

Alignment Length:	477	Identity:	111/477 - (23%)
Similarity:	183/477 - (38%)	Gaps:	124/477 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   298 QKTELSHNLQQLSEKARSTTEFIQRLKGMSDKVTESCMEFERLVHAQCEALIQAIHDRREYLLEA 362
            |:..|...::.|:.|......||..||.|...|..:..:.:..:.|:.::|...:.:.:|.:|..
Human     4 QREALRKIIKTLAVKNEEIQSFIYSLKQMLLNVEANSAKVQEDLEAEFQSLFSLLEELKEGMLMK 68

  Fly   363 IRMDKDTKIRILKDQQSNCTGKLQQTTGLIQFCIEALKETDSAAFLQVGSMLINRVTNTDMTWHQ 427
            |:.|:.::...|::|.:.||..|:.:..|::...:.|:..||..|.|....:.:.||
Human    69 IKQDRASRTYELQNQLAACTRALESSEELLETANQTLQAMDSEDFPQAAKQIKDGVT-------- 125

  Fly   428 EVTNAAPRVSPIVDLTLDDAALARAIDNL-----NFIQMRAVKDGDERCPAAPMTPTILPSDCSA 487
                    ::|...|:|.    |:..||:     :|.|.|.:....:..| .|..|.|..::...
Human   126 --------MAPAFRLSLK----AKVSDNMSHLMVDFAQERQMLQALKFLP-VPSAPVIDLAESLV 177

  Fly   488 ENNSVTVAWQPPNH-SFVEGYVLELDDGSGGEFREVYCG----------------KETICTVDGL 535
            .:|.||:.|:.|:. |.::.||||..       |..:.|                ::|..|:.||
Human   178 ADNCVTLVWRMPDEDSKIDHYVLEYR-------RTNFEGPPRLKEDQPWMVIEGIRQTEYTLTGL 235

  Fly   536 HFNSMY-NARVKAFNSAGEGEYSELIGLQT--------------------AEVAW---------- 569
            .|:..| |.||||.|.|..||:||.:.|:|                    ..|.|
Human   236 KFDMKYMNFRVKACNKAVAGEFSEPVTLETPAFMFRLDASTSHQNLRVDDLSVEWDAMGGKVQDI 300

  Fly   570 ---------FTFDPV------------LSGGAGSGLIFSKNNATVSVEGWEHRVALGSVGFSRGV 613
                     .|..|:            :..|.|....|:..:.||          ||......|.
Human   301 KAREKDGKGRTASPINSPARGTPSPKRMPSGRGGRDRFTAESYTV----------LGDTLIDGGE 355

  Fly   614 HYWEFTIDNYTADTDPAF--GVARIDVARNKMLGKDEKSFAMYIDRQRSWFQ--HNSIHERRVEG 674
            ||||.   .|..|: .||  |||...:.|.:.|||...|:.::::   :|.|  ..:.|..:|:.
Human   356 HYWEV---RYEPDS-KAFGVGVAYRSLGRFEQLGKTAASWCLHVN---NWLQVSFTAKHANKVKV 413

  Fly   675 -GITTGSTIGVLLDLERHTLSF 695
             .......:||..|..:..|||
Human   414 LDAPVPDCLGVHCDFHQGLLSF 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trim9	NP_001188786.1	RING-HC_TRIM9_like_C-I	2..37	CDD:319490
		zf-B_box	250..291	CDD:306989
		ClassIIa_HDAC_Gln-rich-N	298..420	CDD:330228	28/121 (23%)
		FN3	472..564	CDD:238020	34/109 (31%)
		SPRY_PRY_TRIM67_9	561..735	CDD:293947	40/191 (21%)
FSD1	NP_077309.1	ClassIIa_HDAC_Gln-rich-N	4..120	CDD:330228	27/115 (23%)
		FN3	165..265	CDD:238020	33/106 (31%)
		SPRY_PRY_FSD1	270..476	CDD:293958	38/183 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	301..336		4/34 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24099
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010