DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trim9 and Cmya5

DIOPT Version :9

Sequence 1:	NP_001188786.1	Gene:	Trim9 / 34453	FlyBaseID:	FBgn0051721	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_076310.2	Gene:	Cmya5 / 76469	MGIID:	1923719	Length:	3676	Species:	Mus musculus

Alignment Length:	635	Identity:	135/635 - (21%)
Similarity:	224/635 - (35%)	Gaps:	187/635 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   243 KPRGAAQQ-----------RESVCG----EHEETLSQ-YCLSCKAPACGLCIGELR-----HQAH 286
            :||.:|.|           ||||..    |.::|.:: ||.:||:     .:.|:.     |:.|
Mouse  3081 EPRMSASQEVWDRTEDQSARESVTAKTQKEPKKTQAESYCYTCKS-----LVSEMDKALDIHKDH 3140

  Fly   287 DVQSINVTCKAQKTELSHNLQQLSEKARSTTEFIQRLKGMSDKVTESCMEFERLVHAQCEALIQA 351
            :|.:::....|.|.:|...|:.|.||:.....|:..::...:.:.|.|.:.|:.:..|.|.:::.
Mouse  3141 EVSALDTAISAVKVQLGEFLENLQEKSLRIEAFVSEIESFFNTIEEKCSKNEKRLEMQNEEMMKR 3205

  Fly   352 I---HDRREYLLEAIRMDKDTKIRILKDQQSNCTGKLQQTTGLIQFCIEALKETDSAAFL----Q 409
            :   :|.:....|.:   |..|:..|.||..:....:......::..:...:|.|...||    :
Mouse  3206 VLAQYDEKAQSFEEV---KKKKMEFLHDQMVHFLQSMDTAKDTLETIVREAEELDETVFLASFEE 3267

  Fly   410 VGSMLINRVTNT-----------------------DMTWHQEVTNAAPRVSP------------- 438
            :...|::.:.:|                       |....|......||:.|
Mouse  3268 INERLLSAMESTASLENMPAAFSLFEHYDDSSARSDQMLKQVAVPQPPRLEPQEPSSATSTTIAV 3332

  Fly   439 ----------------IVDLTLDDAALARAIDNLNFIQMRAVKDG--------DERC-------- 471
                            .|:...||..:...::....    .||:.        .:||
Mouse  3333 YWSVNKEDVVDSFQVYCVEEPQDDQEINELVEEYRL----TVKESCCIFEDLEPDRCYQVWVMAV 3393

  Fly   472 -------PA-------APMTPTILPSDCSAENNSVTVAWQPPNHSFVEGYVLELDDGSGGEFREV 522
                   |:       ||.|..|...||:...|:.||.|:|.|....|.|.||
Mouse  3394 NFTGCSLPSERAIFRTAPSTAVIHVEDCTVCWNTATVRWRPANPEATETYTLE------------ 3446

  Fly   523 YC--------GKETICTVDGLHF------NSMYNARVKAFNSAGEGEYSELIGLQTAEVAWF--- 570
            ||        |..:...:.||..      |..|...|:|.|::|..|.||...:.|....:.
Mouse  3447 YCRQHSPEGEGLRSFSGIKGLQLKVNLPPNDNYFFYVRATNASGTSEQSEAALISTRGTRFLLLR 3511

  Fly   571 -TFDPVLSGGA-GSGLIFSKNNATVSVEGWEHRVALGSVGFSRGVHYWEFTIDNYTADTDPAF-- 631
             |..|.|...| |:.:.||:......:..     .||....:.|.||||.|:    ||: ||:
Mouse  3512 ETAHPALQISANGTVISFSERRRLTEIPS-----VLGEELPACGQHYWETTV----ADS-PAYRL 3566

  Fly   632 GVARIDVARNKMLGKDEKSFAMYIDRQRSWFQHNSIHERRV--EGGITT-------GSTIGVLLD 687
            |:......|...||:.|          .||:.|.|..:|..  ..||.:       .:.:|:|||
Mouse  3567 GICTSSAVRAGALGQGE----------TSWYMHCSEPQRYTFFYSGIVSEVHATERPARVGILLD 3621

  Fly   688 LERHTLSFLVNEMPQGSVAFRDLY--GVFYPAVSINRGVTLTMHTAMDAP 735
            .....|.|:..|..|.....|..:  || :||.::.:....|:|..::.|
Mouse  3622 YTNQRLLFINAESGQLLFIVRHRFNEGV-HPAFALEKPGRCTLHLGLEPP 3670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trim9	NP_001188786.1	RING-HC_TRIM9_like_C-I	2..37	CDD:319490
		zf-B_box	250..291	CDD:306989	15/61 (25%)
		ClassIIa_HDAC_Gln-rich-N	298..420	CDD:330228	24/128 (19%)
		FN3	472..564	CDD:238020	31/112 (28%)
		SPRY_PRY_TRIM67_9	561..735	CDD:293947	47/191 (25%)
Cmya5	NP_076310.2	iSH2_PI3K_IA_R	3153..3277	CDD:304922	24/126 (19%)
		FN3	3321..3409	CDD:238020	8/91 (9%)
		FN3	3416..3502	CDD:238020	27/97 (28%)
		SPRY	3504..3666	CDD:295394	46/182 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24099
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010