DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trim9 and Cmya5

DIOPT Version :9

Sequence 1:	NP_001188786.1	Gene:	Trim9 / 34453	FlyBaseID:	FBgn0051721	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	XP_006231851.1	Gene:	Cmya5 / 688915	-ID:	-	Length:	3943	Species:	Rattus norvegicus

Alignment Length:	820	Identity:	167/820 - (20%)
Similarity:	271/820 - (33%)	Gaps:	256/820 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 SAAGHNGLHGNGGGAGGGAAAPVTNPNGP--GTRHSSHSSAASTASSNTGSESV---TSDQDQSD 114
            |:.||.          .|.|:|..|.|.|  .:.....|:|.:|.:.....|.:   .|.:::..
  Rat  3235 SSQGHE----------AGNASPEVNLNVPVQVSFPEEESTAGATYAPEVSQEELVPCVSREERLH 3289

  Fly   115 KVSIFSEADSGVVCCSNTSRPVSYAGTGLLPGVGNVVAPPGAAYCLTCPLCRKLVFFDDGGVRNL 179
            .:.:..|.|  .|...|.    .....|:|||.....|||...      |.:........|.|.|
  Rat  3290 NIPVQDEYD--FVDSLNQ----EIVSQGILPGEPYSEAPPKEV------LPQGTESLSHAGEREL 3342

  Fly   180 PTYRAMEAIVDRFCAREALRCQMCETDPKVASLICEQCEIRYCDACRELTHPARGPLAKHTLVKP 244
                                  |.|.:|: .|...|:.:
  Rat  3343 ----------------------MSEGEPR-KSASQEEWD-------------------------- 3358

  Fly   245 RGAAQQ--RESVCGEHEE-----TLSQYCLSCKAPACGLCIGELR-----HQAHDVQSINVTCKA 297
            ||...|  ||||..:.::     .:..||.:||:     .:.|:.     |:.|:|.:::....|
  Rat  3359 RGGEDQSARESVTTKTQKEQKKAQVDSYCYTCKS-----LVSEMDKVLDIHKHHEVSALDTAISA 3418

  Fly   298 QKTELSHNLQQLSEKARSTTEFIQRLKGMSDKVTESCMEFERLVHAQCEALIQAI---HDRREYL 359
            .|.:|...|:.|.||:.....|:..::...:.:.|.|.:.|:.:..|.|.:::.:   :|.:...
  Rat  3419 VKVQLGEFLENLQEKSLRIEAFVSEIESFFNTIEEKCSKNEKRLEMQNEEMMKKVLAQYDEKAQS 3483

  Fly   360 LEAIRMDKDTKIRILKDQQSNCTGKLQQTTGLIQFCIEALKETDSAAFL----QVGSMLINRVTN 420
            .|.:   |..|:..|.||..:....:......::..:...:|.|...||    ::...|::.:.:
  Rat  3484 FEEV---KKKKMEFLHDQMVHFLQSMDTAKDTLETIVREAEELDETVFLASFEEINERLLSAMES 3545

  Fly   421 T-----------------------DMTWHQEVTNAAPRVSP------------------------ 438
            |                       |....|......||:.|
  Rat  3546 TASLENMPAAFSLFEHYDDSSARGDQMLKQVAVPQPPRLEPQEPNSATSTTIAVYWSVNKEDVVD 3610

  Fly   439 -----IVDLTLDDAALARAIDNLNFIQMRAVKDG--------DERC---------------PA-- 473
                 .|:...||..:...::....    .||:.        .:||               |:
  Rat  3611 SFQVYCVEEPQDDQEINELVEEYRL----TVKESCCIFEDLEPDRCYQVWVMAVNFTGCSLPSER 3671

  Fly   474 -----APMTPTILPSDCSAENNSVTVAWQPPNHSFVEGYVLELDDGSGGEFREVYC--------G 525
                 ||.||.|...||:...|:.||.|:|.|....|.|.||            ||        |
  Rat  3672 AIFRTAPFTPVIHVEDCTVCWNTATVRWRPANPEATETYTLE------------YCRQHSPEGEG 3724

  Fly   526 KETICTVDGLHF------NSMYNARVKAFNSAGEGEYSELIGLQTAEVAWF----TFDPVLS-GG 579
            ..:...:.||..      |..|...|:|.|::|..|.||...:.|....:.    |..|.|. ..
  Rat  3725 LRSFSGIKGLQLKVNLSPNDNYFFYVRATNASGTSEQSEAALISTRGTRFLLLRETAHPALQISS 3789

  Fly   580 AGSGLIFSKNNATVSVEGWEHRVALGSVGFSRGVHYWEFTIDNYTADTD-PAF--GVARIDVARN 641
            .|:.:.||:......:..     .||....:.|.||||.|:      || ||:  |:......|.
  Rat  3790 NGTVISFSERRRLTEIPS-----VLGEELPACGQHYWETTV------TDSPAYRLGICSSSAVRA 3843

  Fly   642 KMLGKDEKSFAMYIDRQRSWFQHNSIHERRV--EGGITT-------GSTIGVLLDLERHTLSFLV 697
            ..||:.|.          ||:.|.|..:|..  ..||.:       .:.:|:|||.....|.|:.
  Rat  3844 GALGQGES----------SWYMHCSEPQRYTFFYSGIVSEVHATERPARVGILLDYTNQRLLFVN 3898

  Fly   698 NEMPQ--GSVAFRDLYGVFYPAVSINRGVTLTMHTAMDAP 735
            .|..|  .:|..|...|| :||.::.:....|:|..::.|
  Rat  3899 AESGQLLFTVRHRFNEGV-HPAFALEKPGKCTLHLGLEPP 3937

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trim9	NP_001188786.1	RING-HC_TRIM9_like_C-I	2..37	CDD:319490
		zf-B_box	250..291	CDD:306989	13/52 (25%)
		ClassIIa_HDAC_Gln-rich-N	298..420	CDD:330228	24/128 (19%)
		FN3	472..564	CDD:238020	32/112 (29%)
		SPRY_PRY_TRIM67_9	561..735	CDD:293947	47/192 (24%)
Cmya5	XP_006231851.1	iSH2_PI3K_IA_R	3420..3544	CDD:304922	24/126 (19%)
		FN3	3593..3676	CDD:238020	8/86 (9%)
		FN3	3683..3769	CDD:238020	27/97 (28%)
		SPRY	3771..3933	CDD:295394	46/183 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24099
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010