DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trim9 and trim46a

DIOPT Version :9

Sequence 1:	NP_001188786.1	Gene:	Trim9 / 34453	FlyBaseID:	FBgn0051721	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	XP_005158199.1	Gene:	trim46a / 569905	ZFINID:	ZDB-GENE-110825-1	Length:	773	Species:	Danio rerio

Alignment Length:	820	Identity:	183/820 - (22%)
Similarity:	290/820 - (35%)	Gaps:	259/820 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEDELRCPTCKQLYANPVLLPCFHALCLGCALD--IQTPYSPGSALPGAVNGAGAASAAGHNGLH 63
            ||.||.||.|:::...|::|||.|::|:.||.:  :|..|.|....|
Zfish    26 MERELHCPVCEEMVKQPIVLPCSHSVCVLCAAEVLVQRGYPPPELPP------------------ 72

  Fly    64 GNGGGAGGGAAAPVTNPNGPGTRHSSHSSAASTASSNTGSESVTSDQDQSDKVSIFSEADSGVVC 128
                       .|.|..:.|.||            |...:.......|:.|:|       ...||
Zfish    73 -----------EPNTPTSSPLTR------------SPRQNRRPPPKTDRLDRV-------IRTVC 107

  Fly   129 CSNTSRPVSYAGTGLLPGVGNVVAPPGAAYCLTCPLCRKLVFFDDGG----VRNLPTYRAMEAIV 189
                         |..||......|| ......||.||:.|...:.|    :|||    .:|.||
Zfish   108 -------------GTHPGRRRKDTPP-ILMLFPCPTCRRDVELGERGLADCLRNL----TLERIV 154

  Fly   190 DRF-----CAREALRCQMCETDPKV-ASLICEQCEIRYCDACRELTHPARGPLAKHTLVKPRGAA 248
            :|:     ....|:.||.|:....: |:..|..|...:|:.|.:|.||...|.|:|..:.|..:.
Zfish   155 ERYRHTVSLGTMAIMCQFCKPPQTLEATKGCADCRSNFCNECFKLYHPWGTPRAQHEHILPTHSF 219

  Fly   249 QQRESVCGEHE-ETLSQYCLSCKAPACGLCIGELRHQAHDVQSINVTCKAQKTELSHNLQQLSEK 312
            :.:..||.||| |.|..||.||:...|.||.....|..|.:..|.:..:..|.:::..:..:...
Zfish   220 RPKVLVCVEHEQERLQFYCRSCQRLLCSLCKLRRAHSGHKIMPIALAYQTLKDKITKEMNYILAN 284

  Fly   313 ARSTTEFIQRLK-GMSDKVTESCMEFERLVHAQCEALIQAIHDRRE----YLLEAIRMDKDTKIR 372
            ..|....|.::: |::.....|.:..|:|  :||...::|:...|:    ..||..|..:...:.
Zfish   285 QDSVQAQITQVESGIAQTEVNSAVVKEQL--SQCVNELRAVLAERQGALAMCLEGSRAQRAAALN 347

  Fly   373 I-LKDQQSNCTGKLQQTTGLIQFCIEALKETDSAAFLQVGSMLINRVTNTDMTWHQEVTNAAPRV 436
            . |.::||     |.:..||:.:..|.|||:|.:.|:|...:..||:............:|.|..
Zfish   348 AQLSEKQS-----LLENAGLLTYTQELLKESDQSCFVQAARVTHNRLVKAIENLQHFSLSADPSF 407

  Fly   437 SPIVDLTLDDAALARAIDNLNFIQMRAVKDGDERCPAAPMTPTI----------------LPSDC 485
            .   ...:|.:...:|:.:::|||             ||:.|.|                ||.|.
Zfish   408 R---HFQMDVSRELKALSSMDFIQ-------------APLAPVIDTQKTLAYDQLYLCWRLPQDS 456

  Fly   486 ----------------------------SAENNSVTVAWQPPNHSFVEGYVLELDDGSGGEFREV 522
                                        |:.:|....:||            .|||..|
Zfish   457 APAWHYSVEFQRKVGGAGAVWGRVWSEGSSGSNGTHCSWQ------------RLDDVGG------ 503

  Fly   523 YCGKETICTVDGLHFNSMYNARVKAFNSAGEGEYSELIGLQTAEVAWFTFDPVLS---------- 577
                 |...:|.|..:|:|..||:..|.||.|||||.:.|.|      |..||||
Zfish   504 -----TSAVIDKLEMDSVYVLRVRGCNKAGFGEYSEEVYLHT------TPAPVLSFCLDSRWGLH 557

  Fly   578 ---GGAGSGLIFSKNNATVSVEGWE------------HRVA---LGSVGFSRGVHYWEFTIDNYT 624
               ...|.|..:::     ||.|..            |..:   :..|..::|.|||..::
Zfish   558 AERVALGKGQTYAR-----SVPGMTLLQAADRALTSCHLTSDLLVADVSITQGRHYWACSV---- 613

  Fly   625 ADTDPAFGVARIDVARNKMLGKDEKSFAMYIDRQRSWFQHNSIHERRVE---------------- 673
               :|...:.::.|.   :..|.::.|.:..|.....:..:|.|:...|
Zfish   614 ---EPGSYLVKVGVG---VEAKLQEWFHLPQDMASPRYDPDSGHDSGAEDAQDCPPPFCFLTMGM 672

  Fly   674 --------GGITTGST----------IGVLLDLERHTLSF 695
                    || :..||          :|:.||.|:..|:|
Zfish   673 GKILLPKCGG-SNSSTGPFTAPLPPRLGLCLDFEKGRLTF 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trim9	NP_001188786.1	RING-HC_TRIM9_like_C-I	2..37	CDD:319490	15/36 (42%)
		zf-B_box	250..291	CDD:306989	16/41 (39%)
		ClassIIa_HDAC_Gln-rich-N	298..420	CDD:330228	29/127 (23%)
		FN3	472..564	CDD:238020	31/135 (23%)
		SPRY_PRY_TRIM67_9	561..735	CDD:293947	36/197 (18%)
trim46a	XP_005158199.1	zf-B_box	221..263	CDD:279037	16/41 (39%)
		iSH2_PI3K_IA_R	263..383	CDD:304922	28/126 (22%)
		FN3	430..540	CDD:238020	30/132 (23%)
		SPRY	548..748	CDD:295394	29/180 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24099
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010