DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trim9 and cmya5

DIOPT Version :9

Sequence 1:	NP_001188786.1	Gene:	Trim9 / 34453	FlyBaseID:	FBgn0051721	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_001073454.3	Gene:	cmya5 / 560687	ZFINID:	ZDB-GENE-070630-1	Length:	1759	Species:	Danio rerio

Alignment Length:	792	Identity:	153/792 - (19%)
Similarity:	276/792 - (34%)	Gaps:	183/792 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 TGSESVTSDQDQSDKVSIFSEADSGVVCCSNTSR--------PV-SYAGTGLLPGVGNV------ 150
            |.::|:|:|::.|.||.:.|...:..|.....|:        || ..:...:||....:
Zfish   990 TENKSITADKEDSSKVRLSSVVPTKEVEFEEHSKINDVTTEIPVKENSEIKILPLASTLEKGKKT 1054

  Fly   151 -----------VAPP------GAAYCLTCPL----CRKLVFFDDGGVRNLPTYRAMEAIVDRFCA 194
                       ::||      .::.....||    .:|......||..:|...:.:.:::..:..
Zfish  1055 QIEDITDLPEPISPPPQVDEEDSSVMRVSPLEPEDSKKAYEEIHGGGISLSKNKGVFSLLRSYTP 1119

  Fly   195 REALRCQMCETDPKVASLICEQCEIRYCDACR-ELTHPARGPLAKHTL-----------VKPRGA 247
            :|.|  .....||.|...|.|:.:....|... :.:..||....|..|           |:...:
Zfish  1120 QEDL--SALSFDPDVQRDIAEELDYEMIDEQEAKQSEQARTEDGKICLPDQALEMGFEFVEDLDS 1182

  Fly   248 AQQRESVCGEHE-ETLSQYCLSCKAPACGLCIGELRHQAHDVQSINVTCKAQKTELSHNLQQLSE 311
            ||..:.:..:.| :.:..:||.|   .|.:.:.|..||.|.|.|:.....:.|..||..:..|..
Zfish  1183 AQLADELEEDVEIQPMDAFCLDC---LCPILLSEAEHQNHKVASLGEAFDSMKKRLSEMISVLQS 1244

  Fly   312 KARSTTEFIQRLKGMSDKVTESCMEFERLVHAQCEALIQAIHDRREYLLEAIRMDKDTKIRILKD 376
            ::.:..:|:..|:...:.|.|:..:.|:.:....|..::.:.|:...:.:|:...|..::..|.|
Zfish  1245 RSENIEDFVSELEVAYNTVEENYNDCEKTIKVHNEEELKLVMDQYNEMSQAMEEQKKARLEQLYD 1309

  Fly   377 QQSNCTGKLQQTTGLIQFCIEALKETDSAAFLQVG---SMLINRVTNTDMTWH------------ 426
            |..:....:.:....::...:..:|||...|:...   ||.:|....:.|:..
Zfish  1310 QIVSFQENIDKAKETLETTAKEEEETDPLTFISKSKDISMRLNTALESTMSLELGPRGLLVFEDY 1374

  Fly   427 -------------------------QEVTNAAPRVSPIVDLTLDDAALARAIDNLNFIQMR---- 462
                                     || .|:|...|..|...:::..:   ||......|.
Zfish  1375 AKGKSGNQGKNRQAIPVPQKPHLQPQE-ANSATSTSVTVYWRVNEDDI---IDCFQVYCMEEPQG 1435

  Fly   463 --------AVKDG----------------------------DERCP--AAPMTPTILPSDCSAEN 489
                    .||:.                            .||.|  .||..|.|....|:...
Zfish  1436 AISEEYRVTVKESYCNLEELEPDKCYKVWVMAVNYTGCSMPSERLPFKTAPSVPVINTEQCTVLW 1500

  Fly   490 NSVTVAWQPPNHSFVEGYVLELDDGSGGEFREVYCGKETICTVDG---------LHFNSMYNARV 545
            :|.|:.|.....|.|:.:.||.       .|:..|.:|.:.::.|         |..|..|...:
Zfish  1501 DSATLRWSSVQPSAVDSFTLEY-------CRQYACEREGLRSISGIKGYEQRVLLQPNENYLFYI 1558

  Fly   546 KAFNSAGEGEYSELIGLQTAEVAWFTFDPVLSGGAGSGLIFSKNNATVSVEGWEHRV-------- 602
            |:.|:.|..|.||...:.|.... |.|   |...|.|.|..|::..:|.   :.|..
Zfish  1559 KSVNAGGSSEQSEAALISTRGTR-FHF---LRESAHSVLKVSEDRNSVE---YPHDTYNKMSSVI 1616

  Fly   603 ----ALGSVGFSRGVHYWEFTIDNYTADTDPAFGVARIDVARNKMLGKDEKSFAMYIDRQRSWFQ 663
                .:|.:..|.|.:|||..:....|   ...|:|....::.:.||:|..|:.::........:
Zfish  1617 DCPSVMGEILQSNGYYYWETEVSRCKA---YRIGIAYQTTSQTRTLGEDSASWCLHCVPTSISCR 1678

  Fly   664 HNSIHERRVEGGI---TTGSTIGVLLDLERHTLSFLVNEMPQGSVAFRDLYG-VFYPAVSINRGV 724
            ...:|| |||..|   ...:.||.|||..:..|.|...:..|...:|:..:. ..:|...:.:..
Zfish  1679 FELLHE-RVESDIFVTDIPARIGTLLDYSQGCLFFFNAQSGQVLGSFQHKFAQPCHPVFVLEQPG 1742

  Fly   725 TLTMHTAMDAPK 736
            .|.:...|:.|:
Zfish  1743 NLELKMTMEVPE 1754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trim9	NP_001188786.1	RING-HC_TRIM9_like_C-I	2..37	CDD:319490
		zf-B_box	250..291	CDD:306989	10/41 (24%)
		ClassIIa_HDAC_Gln-rich-N	298..420	CDD:330228	23/124 (19%)
		FN3	472..564	CDD:238020	26/102 (25%)
		SPRY_PRY_TRIM67_9	561..735	CDD:293947	41/189 (22%)
cmya5	NP_001073454.3	iSH2_PI3K_IA_R	1232..1356	CDD:304922	23/123 (19%)
		FN3	1401..1484	CDD:238020	13/86 (15%)
		FN3	1501..1577	CDD:238020	20/82 (24%)
		SPRY_PRY_TRIM76	1579..1749	CDD:293955	39/180 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24099
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010