Protein Alignment Trim9 and TRIM36

DIOPT Version :10

• Sequence 1: NP_001188786.1
• Gene: Trim9 / 34453
• FlyBaseID: FBgn0051721
• Length: 740
• Species: Drosophila melanogaster
• Sequence 2: XP_016865110.1
• Gene: TRIM36 / 55521
• HGNCID: 16280
• Length: 745
• Species: Homo sapiens
• Alignment Length: 826
• Identity: 183/826 - (22%)
• Similarity: 308/826 - (37%)
• Gaps: 198/826 - (23%)

  Fly     1 MEDELRCPTCKQLYANPVLLPCFHALCLGCALDIQTPYSPGSALPGAVNGAGAASAAGHNGLHGN 65
            :|.||.||.||:|:.:|::|||.|::|..|..::..      .|..:.|..|:.:
Human    27 IERELICPACKELFTHPLILPCQHSICHKCVKELLL------TLDDSFNDVGSDN---------- 75

  Fly    66 GGGAGGGAAAPVTNPNGPGTRHSSHSSAASTASSNTGSESVTSDQDQSDKVSIFSEADSGVVCCS 130
                        :|.:.|..|..|.|                  .|:.|:::          ..:
Human    76 ------------SNQSSPRLRLPSPS------------------MDKIDRIN----------RPA 100

  Fly   131 NTSRPVSYAG-TGLLPG-VGNVVAPPGAAYCLTCPLCRKLVFFDDGGVRNLPTYRAMEAIVDRF- 192
            :..|.|.:.| ..||.| ..|.:.|....:  .||.|...|...:.|:..|.....:|.||:|:
Human   101 SQRRSVGWRGHKKLLNGWKRNSLTPRTTVF--PCPGCEHDVDLGERGINGLFRNFTLETIVERYR 163

  Fly   193 ---CAREALRCQMCETDPKVASLICEQCEIRYCDACRELTHPARGPLAKHTLVKPRGAAQQRESV 254
               .|..|:.|.:|:..|:.::..|..|...||:.|.::.||.....|:|..|.|....:.:..:
Human   164 QAARAATAIMCDLCKPPPQESTKSCMDCSASYCNECFKIHHPWGTIKAQHEYVGPTTNFRPKILM 228

  Fly   255 CGEHE-ETLSQYCLSCKAPACGLCIGELRHQAHDVQSINVTCKAQKTELSHNLQQLSEKARSTTE 318
            |.||| |.::.||..|:.|.|.||.....|..|.|.:::...|..|.:||.::..|..|......
Human   229 CPEHETERINMYCELCRRPVCHLCKLGGNHANHRVTTMSSAYKTLKEKLSKDIDYLIGKESQVKS 293

  Fly   319 FIQRLKGMSDKVTESC----MEFERLVHAQCEALIQAIHDRREYLLEAIRMDKDTKIRILKDQQS 379
            .|..| .:..|.|| |    .:.|.:.|  .|.|.:.:.:|:..:|:||...|..::...:.|..
Human   294 QISEL-NLLMKETE-CNGERAKEEAITH--FEKLFEVLEERKSSVLKAIDSSKKLRLDKFQTQME 354

  Fly   380 NCTGKLQQTTGLIQFCIEALKETDSAAFLQVGSMLINRVTNTDMTWHQEVTNAAPRVSPIVDLTL 444
            ...| |.:..||:.:..|.|||||.:.|:|....|..|:        |:.|.:.....|....:.
Human   355 EYQG-LLENNGLVGYAQEVLKETDQSCFVQTAKQLHLRI--------QKATESLKSFRPAAQTSF 410

  Fly   445 DDAAL-----ARAIDNLNFIQMRAVKDGDERCPAAPMTPTILPSDCSAENNSVTVAWQPPNHSFV 504
            :|..:     ...:..|:|.     ..|.:       .|.|........||:: :.|..|.....
Human   411 EDYVVNTSKQTELLGELSFF-----SSGID-------VPEINEEQSKVYNNAL-INWHHPEKDKA 462

  Fly   505 EGYVLEL------DDGSGGEFREVYCGKETICTVDGLHFNSMYNARVKAFNSAGEGEYSELIGLQ 563
            :.||||.      |:.|..|. || ||...|  :..|..:|.|..||:|:..:.....|..:.|.
Human   463 DSYVLEYRKINRDDEMSWNEI-EV-CGTSKI--IQDLENSSTYAFRVRAYKGSICSPCSRELILH 523

  Fly   564 T--AEVAWFTFDPVLSGGAGSGLIFSKNNATVSVEGWEHRVA---------------LGSVGFSR 611
            |  |.|..|.||..........|:..|.:...|..|:...:|               :|..|.::
Human   524 TPPAPVFSFLFDEKCGYNNEHLLLNLKRDRVESRAGFNLLLAAERIQVGYYTSLDYIIGDTGITK 588

  Fly   612 GVHYWEFTIDNYTADTDPAFGVARIDVARNKMLGKDEKSFAMYIDRQRSW-----------FQHN 665
            |.|:|.|.::.|:.       :.::.||.:              |:.:.|           ::.:
Human   589 GKHFWAFRVEPYSY-------LVKVGVASS--------------DKLQEWLRSPRDAVSPRYEQD 632

  Fly   666 SIHERRVEGG----------ITTG------------------------STIGVLLDLERHTLSFL 696
            |.|:...|..          :|.|                        ::||:.||.::..:.|.
Human   633 SGHDSGSEDACFDSSQPFTLVTIGMQKFFIPKSPTSSNEPENRVLPMPTSIGIFLDCDKGKVDFY 697

  Fly   697 VNEMPQGSVAFR---DLYGVFYPAVSINRGVTLTMHTAMDAPKMDY 739
              :|.|....:.   |.....|||.::.....:.:...:.|..::|
Human   698 --DMDQMKCLYERQVDCSHTLYPAFALMGSGGIQLEEPITAKYLEY 741

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trim9	NP_001188786.1	RING-HC_TRIM9-like_C-I	2..>35	CDD:438238	15/32 (47%)
		Bbox1_TRIM9-like_C-I	199..244	CDD:380861	13/44 (30%)
		Bbox2_TRIM9-like	255..291	CDD:380822	15/36 (42%)
		CC_brat-like	298..420	CDD:475168	35/125 (28%)
		FN3	472..564	CDD:238020	26/97 (27%)
		SPRY_PRY_TRIM67_9	561..735	CDD:293947	39/238 (16%)
TRIM36	XP_016865110.1	RING-HC_TRIM36_C-I	28..142	CDD:438414	37/171 (22%)
		Bbox1_TRIM36_C-I	168..222	CDD:380906	16/53 (30%)
		Bbox2_TRIM36_C-I	227..271	CDD:380836	15/43 (35%)
		CC_brat-like	273..397	CDD:475168	36/136 (26%)
		COS	376..424	CDD:465805	10/55 (18%)
		FN3	448..508	CDD:214495	21/64 (33%)
		SPRY_PRY_TRIM36	532..735	CDD:293951	35/225 (16%)