DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trim9 and mid1

DIOPT Version :9

Sequence 1:	NP_001188786.1	Gene:	Trim9 / 34453	FlyBaseID:	FBgn0051721	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_001006876.1	Gene:	mid1 / 448651	XenbaseID:	XB-GENE-494584	Length:	668	Species:	Xenopus tropicalis

Alignment Length:	775	Identity:	182/775 - (23%)
Similarity:	286/775 - (36%)	Gaps:	240/775 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEDELRCPTCKQLYANPVLLPCFHALCLGCALDIQTPYSPGSALPGAVNGAGAASAAGHNGLHGN 65
            :|.||.||.|.:|:.:|:||||.|:||..||
Frog     4 LESELTCPICLELFEDPLLLPCAHSLCFNCA---------------------------------- 34

  Fly    66 GGGAGGGAAAPVTNPNGPGTRHSSHSSAASTASSNTGSESVTSDQDQSDKVSIFSEADSGVVCCS 130
                                    |....|..::|...||:.:.|
Frog    35 ------------------------HRILVSHCANNESVESINAFQ-------------------- 55

  Fly   131 NTSRPVSYAGTGLLPGVGNVVAPPGAAYCLTCPLCRKLVFFDDGGVRNLPTYRAMEAIVDRF--- 192
                                           ||.||.::.....|:..|.....::.|:|||
Frog    56 -------------------------------CPTCRYVITLSKRGLEGLKRNVTLQNIIDRFQKA 89

  Fly   193 -----------------------CAREALRCQMCETD-PKVASLICEQCEIRYCDACRELTHPAR 233
                                   .:.|.:.||.|:.| .:.|...|..||:.||:.|.:.|||.:
Frog    90 SVSGPNSPSETRRERAYDTTNSMTSSEKVLCQFCDQDQAREAVKTCVTCEVSYCEDCLKATHPNK 154

  Fly   234 GPLAKHTLVKPRGAAQQRESVCGEHE-ETLSQYCLSCKAPACGLC--IGELRHQAHDVQSINVTC 295
            .|...|.|::|...:..|..:|.||| |.::.||::.....|.||  :|  ||:.|.|.::....
Frog   155 KPFTGHRLIEPIPDSHIRGLMCLEHEDEKVNMYCVTDDQLICALCKLVG--RHRDHQVAALGDRY 217

  Fly   296 KAQKTELSHNLQQLSEKARSTTEFIQRLKGMSDKVTESCMEFERLVHA---------QCEALIQA 351
            ...|..|..||..|.::   .||    ::.:..|:.::|.:.|  |:|         :.:.||:.
Frog   218 DKLKQSLESNLTNLIKR---NTE----MEILLSKLIQTCQQVE--VNASRQEAKLMEESDQLIEI 273

  Fly   352 IHDRREYLLEAIRMDKDTKIRILKDQQSNCTGKLQQTTGLIQFCIEALKETDSAAFLQVGSMLIN 416
            |..||:.:...|:..|..::|.|..|.:||...::::|.||....::|||.|.|.|||....:..
Frog   274 IQQRRQIIGTKIKEGKVVRLRKLAQQVANCKQCIERSTSLISQAEQSLKENDHARFLQSAKNITE 338

  Fly   417 RVTNTDMTWHQEVTNAAPRVSPIVDL--TLDDAAL-----ARAIDNLNFIQMRAVKDGDERCPAA 474
            ||:        ..|.::..:.|.::|  |.|..||     .:.::.|:::             .|
Frog   339 RVS--------MATASSQVLIPEINLNDTFDTFALDFSREKKLLECLDYL-------------TA 382

  Fly   475 PMTPTILPSDCSAENNSVTVAWQPPNHSFVEGYVLELDDGSGGEFREVYCG-----------KET 528
            |..|.|....|:|..:::||.|...:...|..|.|:....:|.......|.           |:.
Frog   383 PNPPVIREELCTASYDTITVHWTSEDEFSVVSYELQYTIFTGQANVVSLCNSADSWMIVPNIKQN 447

  Fly   529 ICTVDGLHFNSMYNARVKAFNSAGEGEYSELIGLQTAEVAWFTFDPVLSGGAGSGLIFSKNNATV 593
            ..||.||...:.|...|||.|.|| ...||...|:|.... |..||   ..|...|..|.:|.||
Frog   448 HYTVHGLQSGTKYIFIVKAINQAG-SRNSEPGKLKTNSQP-FKLDP---KSAHRKLKVSHDNLTV 507

  Fly   594 SVEGWEHRVA--------------LGSVGFSRGVHYWEFTIDNYTADTDPAFGVARIDVARNKML 644
            ..:....:.:              .|:|....|.||||..|   :..|..|.|:|.....:::.:
Frog   508 ERDETSSKKSHTPERFTSQGSYGVAGNVFLDSGRHYWEVVI---SGSTWYAIGIAYKSAPKHEWI 569

  Fly   645 GKDEKSFAMYIDRQRSW-FQHN--------SIHERRVEGGITTGSTIGVLLDLERHTLSF 695
            ||:..|: ::.....:| .:||        |.|.|||          |:|||.:..:|||
Frog   570 GKNTASW-VFCRCNNNWAVRHNSKEIPIEPSPHLRRV----------GILLDYDNGSLSF 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trim9	NP_001188786.1	RING-HC_TRIM9_like_C-I	2..37	CDD:319490	17/34 (50%)
		zf-B_box	250..291	CDD:306989	16/43 (37%)
		ClassIIa_HDAC_Gln-rich-N	298..420	CDD:330228	37/130 (28%)
		FN3	472..564	CDD:238020	29/102 (28%)
		SPRY_PRY_TRIM67_9	561..735	CDD:293947	41/158 (26%)
mid1	NP_001006876.1	RING_Ubox	8..61	CDD:388418	24/161 (15%)
		Bbox1_MID1_C-I	116..165	CDD:380894	18/48 (38%)
		Bbox2_MID1_C-I	169..215	CDD:380880	16/47 (34%)
		BBC	220..345	CDD:128778	37/141 (26%)
		COS	324..375	CDD:375994	14/58 (24%)
		FN3	396..482	CDD:238020	23/86 (27%)
		SPRY_PRY_TRIM18	486..662	CDD:240472	39/151 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24099
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100