DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trim9 and TRIM67

DIOPT Version :9

Sequence 1:	NP_001188786.1	Gene:	Trim9 / 34453	FlyBaseID:	FBgn0051721	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	XP_016856812.1	Gene:	TRIM67 / 440730	HGNCID:	31859	Length:	854	Species:	Homo sapiens

Alignment Length:	819	Identity:	332/819 - (40%)
Similarity:	455/819 - (55%)	Gaps:	141/819 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEDELRCPTCKQLYANPVLLPCFHALCLGCA--LDIQTP-----------YSPGSALPGAVNGAG 52
            ||:||:||.|..|:..|::|||.|.:||.||  :.:|||           .|.||.|..   ||.
Human     1 MEEELKCPVCGSLFREPIILPCSHNVCLPCARTIAVQTPDGEQHLPQPLLLSRGSGLQA---GAA 62

  Fly    53 AASAAGHNGLHGNG-GGAGGGAAAPVTNPNGPGTRHSSHSSAASTASSNTGSESVTSDQDQSDKV 116
            ||::..|:...|.. |||||.||..:....|.|                         .|.:||:
Human    63 AAASLEHDAAAGPACGGAGGSAAGGLGGGAGGG-------------------------GDHADKL 102

  Fly   117 SIFSEADSGVVCCSNTSRPVSYAGTGLLPGVGNVVAPPGA-------AYC---------LTCPLC 165
            |::||.|||.  .|.|....|..|..:||   .|.||||:       |.|         :|||.|
Human   103 SLYSETDSGY--GSYTPSLKSPNGVRVLP---MVPAPPGSSAAAARGAACSSLSSSSSSITCPQC 162

  Fly   166 RKLVFFDDGGVRNLPTYRAMEAIVDRF-----------CAREALRCQMCE-TDPKVASLICEQCE 218
            .:....|..|:|.....|.:||||.|:           .|.....||:|: |.|:.|:.:||||:
Human   163 HRSASLDHRGLRGFQRNRLLEAIVQRYQQGRGAVPGTSAAAAVAICQLCDRTPPEPAATLCEQCD 227

  Fly   219 IRYCDACRELTHPARGPLAKHTLVK--------------PRGAAQQRES---------------- 253
            :.||.||:...||:|||.|||.||:              |.|.||...|
Human   228 VLYCSACQLKCHPSRGPFAKHRLVQPPPPPPPPAEAASGPTGTAQGAPSGGGGCKSPGGAGAGAT 292

  Fly   254 ---------VCGEHE-ETLSQYCLSCKAPACGLCIGELRHQAHDVQSINVTCKAQKTELSHNLQQ 308
                     .|.||| |..|.||:||:.|.|.||:.|.||..|:|:.:....|..|.:||..|..
Human   293 GGSTARKFPTCPEHEMENYSMYCVSCRTPVCYLCLEEGRHAKHEVKPLGAMWKQHKAQLSQALNG 357

  Fly   309 LSEKARSTTEFIQRLKGMSDKVTESCMEFERLVHAQCEALIQAIHDRREYLLEAIRMDKDTKIRI 373
            :|:||:...||:.:||.:..::.|:.:::|..:.|||:||:.|:..::..||..:..:::.|:::
Human   358 VSDKAKEAKEFLVQLKNILQQIQENGLDYEACLVAQCDALVDALTRQKAKLLTKVTKEREHKLKM 422

  Fly   374 LKDQQSNCTGKLQQTTGLIQFCIEALKETDSAAFLQVGSMLINRVTNTDMTWHQEVTNA-APRVS 437
            :.||.::||.||:|:|||:::|:|.:||.|.:.|||:...||.||..:...|   |..| .|:||
Human   423 VWDQINHCTLKLRQSTGLMEYCLEVIKENDPSGFLQISDALIKRVQVSQEQW---VKGALEPKVS 484

  Fly   438 PIVDLTLDDAALARAIDNLNFIQMRAVKDGDERCPAAPMTPTILPSDCSAENNSVTVAWQPP--N 500
            ...|||||...|.:||..|:||||        :|...|: |.:....|...|||||:||:.|  .
Human   485 AEFDLTLDSEPLLQAIHQLDFIQM--------KCRVPPV-PLLQLEKCCTRNNSVTLAWRMPPFT 540

  Fly   501 HSFVEGYVLELDDGSGGEFREVYCGKETICTVDGLHFNSMYNARVKAFNSAGEGEYSELIGLQTA 565
            ||.|:||:||||||:||:|||||.||||:||:|||||||.||||||||||:|.|.||:.:.|||:
Human   541 HSPVDGYILELDDGAGGQFREVYVGKETLCTIDGLHFNSTYNARVKAFNSSGVGPYSKTVVLQTS 605

  Fly   566 EVAWFTFDPVLSGGAGSG---LIFSKNNATVSVEGWEHRVALGSVGFSRGVHYWEFTIDNYTADT 627
            :||||||||      .||   :|.|.:|.|.:...::.||.||:..||:||||||..:|.|....
Human   606 DVAWFTFDP------NSGHRDIILSNDNQTATCSSYDDRVVLGTAAFSKGVHYWELHVDRYDNHP 664

  Fly   628 DPAFGVARIDVARNKMLGKDEKSFAMYIDRQRSWFQHNSIHERRVEGGITTGSTIGVLLDLERHT 692
            ||||||||..|.::.|||||:|::|||:|..||||.|.:.|..|.|||:..|:|:||||||.:||
Human   665 DPAFGVARASVVKDMMLGKDDKAWAMYVDNNRSWFMHCNSHTNRTEGGVCKGATVGVLLDLNKHT 729

  Fly   693 LSFLVNEMPQGSVAFRDLYGVFYPAVSINRGVTLTMHTA 731
            |:|.:|...||..||..:.|||.||:|:||.|  .:||:
Human   730 LTFFINGQQQGPTAFSHVDGVFMPALSLNRNV--QVHTS 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trim9	NP_001188786.1	RING-HC_TRIM9_like_C-I	2..37	CDD:319490	17/36 (47%)
		zf-B_box	250..291	CDD:306989	20/66 (30%)
		ClassIIa_HDAC_Gln-rich-N	298..420	CDD:330228	44/121 (36%)
		FN3	472..564	CDD:238020	57/93 (61%)
		SPRY_PRY_TRIM67_9	561..735	CDD:293947	88/174 (51%)
TRIM67	XP_016856812.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	155	1.000	Domainoid score	I4224
eggNOG	1	0.900	-	-		E1_KOG4367
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	607	1.000	Inparanoid score	I934
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48085
OrthoDB	1	1.010	-	-		D239986at33208
OrthoFinder	1	1.000	-	-		FOG0003096
OrthoInspector	1	1.000	-	-		otm41941
orthoMCL	1	0.900	-	-		OOG6_105047
Panther	1	1.100	-	-	LDO	PTHR24099
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2070
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.840