Protein Alignment Trim9 and MID1

DIOPT Version :10

• Sequence 1: NP_001188786.1
• Gene: Trim9 / 34453
• FlyBaseID: FBgn0051721
• Length: 740
• Species: Drosophila melanogaster
• Sequence 2: NP_000372.1
• Gene: MID1 / 4281
• HGNCID: 7095
• Length: 667
• Species: Homo sapiens
• Alignment Length: 789
• Identity: 192/789 - (24%)
• Similarity: 291/789 - (36%)
• Gaps: 253/789 - (32%)

  Fly     1 MEDELRCPTCKQLYANPVLLPCFHALCLGCALDIQTPYSPGSALPGAVNGAGAASAAGHNGLHGN 65
            :|.||.||.|.:|:.:|:||||.|:||..||
Human     4 LESELTCPICLELFEDPLLLPCAHSLCFNCA---------------------------------- 34

  Fly    66 GGGAGGGAAAPVTNPNGPGTRHSSHSSAASTASSNTGSESVTSDQDQSDKVSIFSEADSGVVCCS 130
                                    |....|..::|...||:|:.|
Human    35 ------------------------HRILVSHCATNESVESITAFQ-------------------- 55

  Fly   131 NTSRPVSYAGTGLLPGVGNVVAPPGAAYCLTCPLCRKLVFFDDGGVRNLPTYRAMEAIVDRF--- 192
                                           ||.||.::.....|:..|.....::.|:|||
Human    56 -------------------------------CPTCRHVITLSQRGLDGLKRNVTLQNIIDRFQKA 89

  Fly   193 ----------------------CAREALRCQMCETDP-KVASLICEQCEIRYCDACRELTHPARG 234
                                  .:.|.:.||.|:.|| :.|...|..||:.|||.|.:.|||.:.
Human    90 SVSGPNSPSETRRERAFDANTMTSAEKVLCQFCDQDPAQDAVKTCVTCEVSYCDECLKATHPNKK 154

  Fly   235 PLAKHTLVKPRGAAQQRESVCGEHE-ETLSQYCLSCKAPACGLC--IGELRHQAHDVQSINVTCK 296
            |...|.|::|...:..|..:|.||| |.::.||::.....|.||  :|  ||:.|.|.:::....
Human   155 PFTGHRLIEPIPDSHIRGLMCLEHEDEKVNMYCVTDDQLICALCKLVG--RHRDHQVAALSERYD 217

  Fly   297 AQKTELSHNLQQLSEKARSTTEFIQRLKGMSDKVTESCMEFERLVHA---------QCEALIQAI 352
            ..|..|..||..|.::   .||    |:.:..|:.::|...|  |:|         :|:.||:.|
Human   218 KLKQNLESNLTNLIKR---NTE----LETLLAKLIQTCQHVE--VNASRQEAKLTEECDLLIEII 273

  Fly   353 HDRREYLLEAIRMDKDTKIRILKDQQSNCTGKLQQTTGLIQFCIEALKETDSAAFLQVGSMLINR 417
            ..||:.:...|:..|..::|.|..|.:||...::::..||.....:|||.|.|.|||....:..|
Human   274 QQRRQIIGTKIKEGKVMRLRKLAQQIANCKQCIERSASLISQAEHSLKENDHARFLQTAKNITER 338

  Fly   418 VTNTDMTWHQEVTNAAPRVSPIVDL--TLDDAAL-----ARAIDNLNFIQMRAVKDGDERCPAAP 475
            |:        ..|.::..:.|.::|  |.|..||     .:.::.|:::             .||
Human   339 VS--------MATASSQVLIPEINLNDTFDTFALDFSREKKLLECLDYL-------------TAP 382

  Fly   476 MTPTILPSDCSAENNSVTVAWQPPNHSFVEGYVLELDDGSGGEFREVYCG-----------KETI 529
            ..|||....|:|..:::||.|...:...|..|.|:....:|.......|.           |:..
Human   383 NPPTIREELCTASYDTITVHWTSDDEFSVVSYELQYTIFTGQANVVSLCNSADSWMIVPNIKQNH 447

  Fly   530 CTVDGLHFNSMYNARVKAFNSAGEGEYSELIGLQTAEVAWFTFDPVLSGGAGSGLIFSKNNATV- 593
            .||.||...:.|...|||.|.|| ...||...|:|.... |..||   ..|...|..|.:|.||
Human   448 YTVHGLQSGTKYIFMVKAINQAG-SRSSEPGKLKTNSQP-FKLDP---KSAHRKLKVSHDNLTVE 507

  Fly   594 ---------------SVEGWEHRVALGSVGFSRGVHYWEFTIDNYTADTDPAFGVARIDVARNKM 643
                           :.:| .:.|| |:|....|.||||..|   :..|..|.|:|.....:::.
Human   508 RDESSSKKSHTPERFTSQG-SYGVA-GNVFIDSGRHYWEVVI---SGSTWYAIGLAYKSAPKHEW 567

  Fly   644 LGKDEKSFAMYIDRQRSWFQHNS--------IHERRVEGGITTGSTIGVLLDLERHTLSFLVNEM 700
            :||:..|:|:.........:|||        .|.|||          |:|||.:
Human   568 IGKNSASWALCRCNNNWVVRHNSKEIPIEPAPHLRRV----------GILLDYD----------- 611

  Fly   701 PQGSVAFRD 709
             .||:||.|
Human   612 -NGSIAFYD 619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trim9	NP_001188786.1	RING-HC_TRIM9-like_C-I	2..>35	CDD:438238	17/32 (53%)
		Bbox1_TRIM9-like_C-I	199..244	CDD:380861	19/45 (42%)
		Bbox2_TRIM9-like	255..291	CDD:380822	15/38 (39%)
		CC_brat-like	298..420	CDD:475168	38/130 (29%)
		FN3	472..564	CDD:238020	30/102 (29%)
		SPRY_PRY_TRIM67_9	561..735	CDD:293947	46/173 (27%)
MID1	NP_000372.1	RING-HC_MID1	3..74	CDD:438411	29/178 (16%)
		Bbox1_MID1_C-I	115..164	CDD:380894	20/48 (42%)
		Bbox2_MID1_C-I	168..214	CDD:380880	16/47 (34%)
		CC_brat-like	219..344	CDD:475168	38/141 (27%)
		COS	323..374	CDD:465805	14/58 (24%)
		FN3	381..481	CDD:238020	30/100 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	471..524		13/56 (23%)
		SPRY_PRY_TRIM18	485..661	CDD:240472	44/166 (27%)