DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trim9 and MID1

DIOPT Version :9

Sequence 1:	NP_001188786.1	Gene:	Trim9 / 34453	FlyBaseID:	FBgn0051721	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_000372.1	Gene:	MID1 / 4281	HGNCID:	7095	Length:	667	Species:	Homo sapiens

Alignment Length:	789	Identity:	192/789 - (24%)
Similarity:	291/789 - (36%)	Gaps:	253/789 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEDELRCPTCKQLYANPVLLPCFHALCLGCALDIQTPYSPGSALPGAVNGAGAASAAGHNGLHGN 65
            :|.||.||.|.:|:.:|:||||.|:||..||
Human     4 LESELTCPICLELFEDPLLLPCAHSLCFNCA---------------------------------- 34

  Fly    66 GGGAGGGAAAPVTNPNGPGTRHSSHSSAASTASSNTGSESVTSDQDQSDKVSIFSEADSGVVCCS 130
                                    |....|..::|...||:|:.|
Human    35 ------------------------HRILVSHCATNESVESITAFQ-------------------- 55

  Fly   131 NTSRPVSYAGTGLLPGVGNVVAPPGAAYCLTCPLCRKLVFFDDGGVRNLPTYRAMEAIVDRF--- 192
                                           ||.||.::.....|:..|.....::.|:|||
Human    56 -------------------------------CPTCRHVITLSQRGLDGLKRNVTLQNIIDRFQKA 89

  Fly   193 ----------------------CAREALRCQMCETDP-KVASLICEQCEIRYCDACRELTHPARG 234
                                  .:.|.:.||.|:.|| :.|...|..||:.|||.|.:.|||.:.
Human    90 SVSGPNSPSETRRERAFDANTMTSAEKVLCQFCDQDPAQDAVKTCVTCEVSYCDECLKATHPNKK 154

  Fly   235 PLAKHTLVKPRGAAQQRESVCGEHE-ETLSQYCLSCKAPACGLC--IGELRHQAHDVQSINVTCK 296
            |...|.|::|...:..|..:|.||| |.::.||::.....|.||  :|  ||:.|.|.:::....
Human   155 PFTGHRLIEPIPDSHIRGLMCLEHEDEKVNMYCVTDDQLICALCKLVG--RHRDHQVAALSERYD 217

  Fly   297 AQKTELSHNLQQLSEKARSTTEFIQRLKGMSDKVTESCMEFERLVHA---------QCEALIQAI 352
            ..|..|..||..|.::   .||    |:.:..|:.::|...|  |:|         :|:.||:.|
Human   218 KLKQNLESNLTNLIKR---NTE----LETLLAKLIQTCQHVE--VNASRQEAKLTEECDLLIEII 273

  Fly   353 HDRREYLLEAIRMDKDTKIRILKDQQSNCTGKLQQTTGLIQFCIEALKETDSAAFLQVGSMLINR 417
            ..||:.:...|:..|..::|.|..|.:||...::::..||.....:|||.|.|.|||....:..|
Human   274 QQRRQIIGTKIKEGKVMRLRKLAQQIANCKQCIERSASLISQAEHSLKENDHARFLQTAKNITER 338

  Fly   418 VTNTDMTWHQEVTNAAPRVSPIVDL--TLDDAAL-----ARAIDNLNFIQMRAVKDGDERCPAAP 475
            |:        ..|.::..:.|.::|  |.|..||     .:.::.|:::             .||
Human   339 VS--------MATASSQVLIPEINLNDTFDTFALDFSREKKLLECLDYL-------------TAP 382

  Fly   476 MTPTILPSDCSAENNSVTVAWQPPNHSFVEGYVLELDDGSGGEFREVYCG-----------KETI 529
            ..|||....|:|..:::||.|...:...|..|.|:....:|.......|.           |:..
Human   383 NPPTIREELCTASYDTITVHWTSDDEFSVVSYELQYTIFTGQANVVSLCNSADSWMIVPNIKQNH 447

  Fly   530 CTVDGLHFNSMYNARVKAFNSAGEGEYSELIGLQTAEVAWFTFDPVLSGGAGSGLIFSKNNATV- 593
            .||.||...:.|...|||.|.|| ...||...|:|.... |..||   ..|...|..|.:|.||
Human   448 YTVHGLQSGTKYIFMVKAINQAG-SRSSEPGKLKTNSQP-FKLDP---KSAHRKLKVSHDNLTVE 507

  Fly   594 ---------------SVEGWEHRVALGSVGFSRGVHYWEFTIDNYTADTDPAFGVARIDVARNKM 643
                           :.:| .:.|| |:|....|.||||..|   :..|..|.|:|.....:::.
Human   508 RDESSSKKSHTPERFTSQG-SYGVA-GNVFIDSGRHYWEVVI---SGSTWYAIGLAYKSAPKHEW 567

  Fly   644 LGKDEKSFAMYIDRQRSWFQHNS--------IHERRVEGGITTGSTIGVLLDLERHTLSFLVNEM 700
            :||:..|:|:.........:|||        .|.|||          |:|||.:
Human   568 IGKNSASWALCRCNNNWVVRHNSKEIPIEPAPHLRRV----------GILLDYD----------- 611

  Fly   701 PQGSVAFRD 709
             .||:||.|
Human   612 -NGSIAFYD 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trim9	NP_001188786.1	RING-HC_TRIM9_like_C-I	2..37	CDD:319490	17/34 (50%)
		zf-B_box	250..291	CDD:306989	16/43 (37%)
		ClassIIa_HDAC_Gln-rich-N	298..420	CDD:330228	38/130 (29%)
		FN3	472..564	CDD:238020	30/102 (29%)
		SPRY_PRY_TRIM67_9	561..735	CDD:293947	46/173 (27%)
MID1	NP_000372.1	RING-HC_MID1	8..61	CDD:319667	25/161 (16%)
		Bbox1_MID1_C-I	115..164	CDD:380894	20/48 (42%)
		Bbox2_MID1_C-I	168..214	CDD:380880	16/47 (34%)
		BBC	219..344	CDD:128778	38/141 (27%)
		COS	323..374	CDD:408352	14/58 (24%)
		FN3	381..481	CDD:238020	30/100 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	471..524		13/56 (23%)
		SPRY_PRY_TRIM18	485..661	CDD:240472	44/166 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24099
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010