DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trim9 and trim36

DIOPT Version :9

Sequence 1:	NP_001188786.1	Gene:	Trim9 / 34453	FlyBaseID:	FBgn0051721	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_001349370.1	Gene:	trim36 / 406849	ZFINID:	ZDB-GENE-040426-2936	Length:	759	Species:	Danio rerio

Alignment Length:	763	Identity:	183/763 - (23%)
Similarity:	294/763 - (38%)	Gaps:	169/763 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEDELRCPTCKQLYANPVLLPCFHALCLGCALDIQTPYSPGSALPGAVNGAGAASAAGHNGLHGN 65
            :|.||.||.||:|:.:|::|||.|::|..|..::..|
Zfish    26 IERELICPICKELFTHPLILPCQHSICHRCVKELLFP---------------------------- 62

  Fly    66 GGGAGGGAAAPVTNPNGPGTRHSSHSSAASTASSNTGSESVTSDQDQSDKVSIFSEADSGVVCCS 130
                               ....|.|:.|.:.|||.||..........||:     ..||.:|..
Zfish    63 -------------------NHEDSFSTDAGSESSNPGSPRSRVPSPGLDKL-----VRSGSICSP 103

  Fly   131 NTSRPVSYAGTGLLPGVGNVVAPPGAAYCLTCPLCRKLVFFDDGGVRNLPTYRAMEAIVDRF--C 193
            ...|      :.:.|.|.:          ..||.|:..:...:.|:..|.....:|:||:|:  .
Zfish   104 GWRR------SSVTPRVTS----------FPCPGCQHDIDLGERGISMLFRNFTLESIVERYRQA 152

  Fly   194 ARE--ALRCQMCETDPKVASLICEQCEIRYCDACRELTHPARGPLAKHTLVKPRGAAQQRESVCG 256
            ||.  |:.|.:|:..|:.|:..|..|:..:|:.|.:|.||...|.|:|..|.|....:.:..:|.
Zfish   153 ARAAVAIMCGVCKPPPQEATKSCMDCKASFCNECFKLHHPWGTPRAQHEYVGPTTNFRPKVLMCP 217

  Fly   257 EHE-ETLSQYCLSCKAPACGLCIGELRHQAHDVQSINVTCKAQKTELSHNLQQLSEKARSTTEFI 320
            ||| |.::.||..|:.|.|.||.....|..|.|.|::...|..|.:||.::..|..|.......|
Zfish   218 EHEMEKVNMYCEVCRRPVCHLCKLGGSHANHRVTSMSSAYKILKEKLSKSIHYLISKEEQVRTQI 282

  Fly   321 QRLKGMSDKVTESCMEFERLVHAQCEALIQAIHDRREYLLEAIRMDKDTKIRILKDQQSNCTGKL 385
            ..|:.:.....|:....||..:...|.|..|:.:||..:|.|::..:..::..|:.|.....|.|
Zfish   283 TALELLMRSTEENGQLAERRANEHFERLQVALQERRAEMLWAVQQCRSRRVERLRAQVEEYQGML 347

  Fly   386 QQTTGLIQFCIEALKETDSAAFLQVGSMLINRVTNTDMTWHQEVTNAAPRVSPIVDLTLDDAALA 450
             :.:||:.:..|.|||||.:.|:|...:|..|:        |:.|::.....|....:.::..|.
Zfish   348 -ENSGLVGYAQEVLKETDQSCFVQTAKLLHVRI--------QKATDSLKTFQPAASSSFEEFQLD 403

  Fly   451 RAIDNLNFIQMRAVKDGDERCPAAPMTPTILPSDCSAENNSVTVAWQPPNHS------FVEGYVL 509
            .:.:.   |.::.:..|     ..|..|.:..|.|...|.:: :.|:.|..|      .:|...|
Zfish   404 TSREE---ILLKELSFG-----GVPDAPVLDLSRCRVYNEAL-LHWRLPEDSVPTDRHLLEFRKL 459

  Fly   510 ELDDGSGGEFRE--------VYCGKETICTVDGLHFNSMYNARVKAFNSAGEGEYSELIGLQTAE 566
            :.|:....|..|        ||.....:|.:|.   ::.|..|||:..:.....||..:.|.|..
Zfish   460 QQDEEEEKEEVERCWRTSESVYGSSTVVCDLDR---DARYAFRVKSCRNGVCSAYSPEVTLHTPP 521

  Fly   567 VAWFTFDPVLSGGAG---SGLIFSKNNATV-SVEGWEHRVA---------------LGSVGFSRG 612
            ...|:|  :.|...|   ..|..|:..|:| ||.|....:|               :|..|.|:|
Zfish   522 APVFSF--LFSDSCGFSAERLQLSRRRASVESVAGMSVLLAAERVQTGSYTCLDYIIGDTGISQG 584

  Fly   613 VHYWEFTIDNYTADTDPAFGVARIDVARNKML-------------------GKDEKSFAMYID-- 656
            .|||.|.:       |||..:.::.||.:..|                   |.|..|..:.:|
Zfish   585 RHYWAFRV-------DPASYLVKVGVASDCKLADWFHGPRDSSSPRFDQDSGHDSGSEDVCVDVC 642

  Fly   657 ---------RQRSWFQHNSIHERRVEGGITTGSTIGVLLDLERHTLSF 695
                     ..|.:.......|.||   :...:.|||.||.|...:||
Zfish   643 QPFLLLTVGMGRLFVPKPPAPESRV---LPLPARIGVCLDYEAGRVSF 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trim9	NP_001188786.1	RING-HC_TRIM9_like_C-I	2..37	CDD:319490	15/34 (44%)
		zf-B_box	250..291	CDD:306989	15/41 (37%)
		ClassIIa_HDAC_Gln-rich-N	298..420	CDD:330228	33/121 (27%)
		FN3	472..564	CDD:238020	24/105 (23%)
		SPRY_PRY_TRIM67_9	561..735	CDD:293947	44/184 (24%)
trim36	NP_001349370.1	RING-HC_TRIM36	27..129	CDD:319670	35/169 (21%)
		RING-HC finger (C3HC4-type)	32..122	CDD:319670	31/157 (20%)
		zf-B_box	211..253	CDD:306989	15/41 (37%)
		ClassIIa_HDAC_Gln-rich-N	260..384	CDD:330228	34/132 (26%)
		FN3	420..519	CDD:238020	24/102 (24%)
		SPRY	527..705	CDD:322017	41/173 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24099
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010