DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trim9 and mtgo

DIOPT Version :9

Sequence 1:	NP_001188786.1	Gene:	Trim9 / 34453	FlyBaseID:	FBgn0051721	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_001137829.1	Gene:	mtgo / 34987	FlyBaseID:	FBgn0259735	Length:	2064	Species:	Drosophila melanogaster

Alignment Length:	497	Identity:	102/497 - (20%)
Similarity:	156/497 - (31%)	Gaps:	153/497 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   294 TCKAQKTELSHNLQQLSEKARSTTEFIQRLKGMSDKVTESCMEFERLVHAQCEALIQAIHDRREY 358
            |.|:...|...:..:...|...::||....:|     .::|.|...|          :.:.|..:
  Fly  1450 TLKSASQERKEDDSEEEVKEPPSSEFHNCYQG-----PQTCAELRNL----------SPYTRYHF 1499

  Fly   359 LLEAIRMDKDTKIRILKDQQSNCTGKLQQTTGLIQFCIEALKETDSAAFLQVGSMLINRVTNTDM 423
            .::|                ||..| ...::.:|..|..|  ....|..:|........||   :
  Fly  1500 RIQA----------------SNSAG-TGNSSDVISVCTPA--AVPGAPQMQGYEFTAQEVT---L 1542

  Fly   424 TWHQEVTNAAPRVSPIVD-----LTLDDAALARAIDNL--------NFIQMRAVKDGDERC---- 471
            .|.|...:.:|..|..::     :...||.....:..|        ....:.|:..|....
  Fly  1543 NWTQPAAHGSPICSYNIEYGERTIATPDACTRYTVSGLMPETGYKFRVQAVNAIGAGAFSAYAKL 1607

  Fly   472 ---PAAPMTPTILPSDCS-AENNSVTVAW-----------QPPNHS------FVEGYVLELDDGS 515
               ||.|..|.:   :|| |.:|.:.:.|           .|..:.      |||.||     ..
  Fly  1608 TTQPAPPAPPRL---ECSGAGHNYIKLKWGENGNGKVVNSNPSGNGGDFTKYFVEMYV-----AR 1664

  Fly   516 GGEFREVYCGKETICTVDGLHFNSMYNARVKAF-NSAGEGEYSELIGLQTAEVAWFTFDP----- 574
            ..:|:.||.|...:|.|..|...|.|..|:.|. :.||:|:|||....:|:........|
  Fly  1665 AKQFQAVYSGTNCMCKVHKLQERSSYTFRIYAHTDRAGDGDYSEEFVFETSATLPANIKPPRVVQ 1729

  Fly   575 -------VLSGGAGSGLIF----SKNNATVSVEGWEHRVALG-----------------SVGFSR 611
                   .|.|..|..|..    |||:....||.......||                 |.|.|.
  Fly  1730 EGSVCLMELPGQLGMQLTLEWQHSKNSFNDRVEYELQYAVLGAAELEGESLSPKGRSSSSSGSSN 1794

  Fly   612 GV------HYW---------EFTIDNYTADTDPAFGVARIDVARNKML--GKDEKSFAMYIDRQ- 658
            |.      |.:         :|||||..|.|...|.|..:.:|....|  |:........:..:
  Fly  1795 GAPINLPNHDYRQLYRGPETKFTIDNLAAGTCYQFRVCPVRIAAGGELLYGQPSSPLRYQVPSEL 1859

  Fly   659 --RSWFQHNSIH--------------ERRVEGGITTGSTIGV 684
              .|...|:.:|              .|::..|  .|||.|:
  Fly  1860 DPSSATCHHHLHGSTATPAMASSQRSSRKLSAG--NGSTNGL 1899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trim9	NP_001188786.1	RING-HC_TRIM9_like_C-I	2..37	CDD:319490
		zf-B_box	250..291	CDD:306989
		ClassIIa_HDAC_Gln-rich-N	298..420	CDD:330228	19/121 (16%)
		FN3	472..564	CDD:238020	32/110 (29%)
		SPRY_PRY_TRIM67_9	561..735	CDD:293947	39/191 (20%)
mtgo	NP_001137829.1	FN3	930..1025	CDD:238020
		FN3	1037..1124	CDD:238020
		FN3	<1149..1216	CDD:238020
		FN3	1221..1312	CDD:238020
		FN3	1334..1409	CDD:238020
		FN3	1415..1520	CDD:238020	16/101 (16%)
		FN3	1525..1609	CDD:238020	13/86 (15%)
		FN3	1619..1714	CDD:238020	28/102 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24099
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100