DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trim9 and ftr82

DIOPT Version :9

Sequence 1:	NP_001188786.1	Gene:	Trim9 / 34453	FlyBaseID:	FBgn0051721	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_001068571.1	Gene:	ftr82 / 338307	ZFINID:	ZDB-GENE-030219-207	Length:	573	Species:	Danio rerio

Alignment Length:	726	Identity:	142/726 - (19%)
Similarity:	232/726 - (31%)	Gaps:	230/726 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DELRCPTCKQLYANPVLLPCFHALCLGCALDIQTPYSPGSALPGAVNGAGAASAAGHNGLHGNGG 67
            |...||.|.:|..:||.:||.|:.|:.|.                   :|..:.|.:.|::....
Zfish     8 DYFNCPLCTELLRDPVAIPCGHSFCMDCI-------------------SGYWNEADYTGIYICPQ 53

  Fly    68 GAGGGAAAPVTNPNGPGTRHSSHSSAASTASSNTGSESVTSDQDQSDKVSIFSEADSGVVCCSNT 132
            ........||..||...|:                                             .
Zfish    54 CRITFTQRPVLRPNATLTK---------------------------------------------V 73

  Fly   133 SRPVSYAGTGLLPGVGNVVAPPGAAYCLTCPLCRKLVFFDDGGVRNLPTYRAMEAIVDRFCAREA 197
            :..:...|..|.|......|.||...|                               .||..:.
Zfish    74 AEKIKKTGLNLTPPSNGSCAGPGDVPC-------------------------------DFCTGQK 107

  Fly   198 LRCQMCETDPKVASLICEQCEIRYCDACREL-THPARGPLAKHTLVKPRGAAQQRESVCGEHEET 261
            |:          |...|..|...||:  :.| .|.......:|.||...|...::  :|.:|:::
Zfish   108 LK----------AVKSCLNCLASYCE--KHLKPHYESATFKRHKLVDELGNLDRK--ICPQHQKS 158

  Fly   262 LSQYCLSCKAPACGLC-IGELRHQAHDVQSINVTCKAQKTE----LSHNLQQLSEKARSTTEFIQ 321
            |..:|.:.:...|.:| :.|  |:.||:    |:.:|::.|    |..:..::.:|.:..|:.::
Zfish   159 LELFCRTDQMCICAICTVSE--HKGHDI----VSAEAERGEKQKLLGVSQAEIKQKCQQRTKELE 217

  Fly   322 RLKGMSDKVTESCMEFERLVHAQCEALIQAIHDRREYLLEAIRMDKDTKIRILKDQQSNCTGKLQ 386
            .||...|.:..|............:.:|.:|...|..:.:.|.:::    |....|......:|:
Zfish   218 ELKTAVDSLKGSAQRAMAESKKMFDEMITSIERMRSEVTKMININE----RAAFSQAEGLMERLE 278

  Fly   387 Q--------TTGLIQFCIEALKETDSAAFLQVGSMLINRVTNTDMTWHQEVTNAAPRVSPIVDLT 443
            |        .|||.|.    ....|...|||..:.|   .|.||       ....|||:...|.:
Zfish   279 QEIDELKKKETGLKQL----YSTEDHIHFLQNFNYL---CTPTD-------DGFIPRVTLNPDFS 329

  Fly   444 LDDAALARA-----IDNLNFIQMRAVKDGDERCPAAPMTPTILPSDCSAENNSV-TVAWQPPNHS 502
            ...|..|.|     ::.|...::|.:.......|.  .|......:.:|....: ||...||
Zfish   330 FSSARKAVAEIKERLEELGRDELRKISKSVNEVPV--YTVENRTKEKTARAKEIHTVDSSPP--- 389

  Fly   503 FVEGYVLELDDGSGGEFREVYCGKETICTVDGLHFNSMYNARVKAFNSAGEGEYSELIGLQTAEV 567
                    ::..:..||.:.||         .|..:| :.|..:.:.|.|..:......||....
Zfish   390 --------VEPKTRSEFLKYYC---------QLKLDS-HTAHKELYLSEGGKKVIRTRDLQPYSD 436

  Fly   568 AWFTFDPVLSGGAGSGLIFSKNNATVSVEGWEHRVALGSVGFSRGVHYW------EFTIDNYTAD 626
            ....||.           |::              .|...|.|.|.:||      ||:|
Zfish   437 NQDRFDS-----------FAR--------------VLCREGLSGGRYYWEVEWSGEFSI------ 470

  Fly   627 TDPAFGVARIDVARNK-----MLGKDEKSFAMYID--RQRSWFQHNSIHERRVEGGITTGSTIGV 684
                 |||...::|..     :||.::||:::...  ...:|  ||.. ::.|.|  ...|.|||
Zfish   471 -----GVAYRGISRKGKGSLCLLGYNDKSWSLLCSDTGYSAW--HNRA-DKAVSG--PHSSRIGV 525

  Fly   685 LLDLERHTLSF 695
            .||.....|||
Zfish   526 FLDHSAGVLSF 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trim9	NP_001188786.1	RING-HC_TRIM9_like_C-I	2..37	CDD:319490	12/33 (36%)
		zf-B_box	250..291	CDD:306989	10/41 (24%)
		ClassIIa_HDAC_Gln-rich-N	298..420	CDD:330228	25/133 (19%)
		FN3	472..564	CDD:238020	17/92 (18%)
		SPRY_PRY_TRIM67_9	561..735	CDD:293947	36/148 (24%)
ftr82	NP_001068571.1	zf-C3HC4_4	12..54	CDD:291880	14/60 (23%)
		zf-B_box	148..186	CDD:279037	10/45 (22%)
		DUF4200	190..295	CDD:290574	20/112 (18%)
		SPRY_PRY_SNTX	395..570	CDD:294002	45/193 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910