DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trim9 and Fsd1l

DIOPT Version :9

Sequence 1:	NP_001188786.1	Gene:	Trim9 / 34453	FlyBaseID:	FBgn0051721	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	XP_008761944.1	Gene:	Fsd1l / 313208	RGDID:	1564809	Length:	508	Species:	Rattus norvegicus

Alignment Length:	528	Identity:	116/528 - (21%)
Similarity:	199/528 - (37%)	Gaps:	136/528 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   297 AQKTELSHNLQQLSEKARSTTEFI----QRLKGMSDKVTESCMEFERLVHAQCEALIQAIHDRRE 357
            :||..|...:..|:.|......||    ..|||:.:..:....|.:.    :.::|...:.|.:|
  Rat     3 SQKEALQRIISTLANKNDEIQNFIDTLNHTLKGVQENSSNILSELDE----EFDSLYSILDDVKE 63

  Fly   358 YLLEAIRMDKDTKIRILKDQQSNCTGKLQQTTGLIQFCIEALKETDSAAFLQVGSMLINRVTNTD 422
            .::..|:.::..|.:.|:.|.|.|...|:.:..|::|...:|...:...|.:....:.:|||
  Rat    64 SMINTIKQEQVHKSQELQSQLSQCNNALENSEELLEFATRSLDIKEPEEFSKAARQIKDRVT--- 125

  Fly   423 MTWHQEVTNA-----APRVSP-IVDLTLDDAALARAIDNLNFIQMRAVKDGDERCPAAPMTPTIL 481
                  :.:|     .|:||. :..|.:|.:...:.:..|.|:.:             |..|.|.
  Rat   126 ------MASAFRLSLKPKVSDNMTHLMVDFSQERQMLQTLKFLPV-------------PKAPEID 171

  Fly   482 PSDCSAENNSVTVAWQ-PPNHSFVEGYVLE--------------------LDDGSGGEFREVYCG 525
            |.:|...:|||||||: |...:.::.:::|                    :|:..|.|:
  Rat   172 PVECLVADNSVTVAWRMPEEDNKIDHFIMEYRKTNFEGLPRVKDERCWEVIDNIKGTEY------ 230

  Fly   526 KETICTVDGLHFNSMY-NARVKAFNSAGEGEYSELIGLQT-----------------AEVAWFTF 572
                 |:.||.|:|.| |.||:|.|.|..||||:.:.|:|                 .|.:...:
  Rat   231 -----TLSGLKFDSKYMNFRVRARNKAVAGEYSDPVTLETKALNFSLDNSSSHLNLKVEDSCVEW 290

  Fly   573 DPVLSGGAGSGLIFSKNNATV--------------------------SVEGWEHR------VALG 605
            ||....|..|.:...:|..:|                          :|.|...|      ..||
  Rat   291 DPTGGKGQESKIKGKENKGSVHVTSLKKHTRSGTPSPKRTSVGSRPPAVRGSRDRFTGESYTVLG 355

  Fly   606 SVGFSRGVHYWEFTID----NYTADTDPAFGVARIDVARNKMLGKDEKSFAMYIDRQRSWFQHN- 665
            ......|.||||....    :|:.      |||...:.:...|||...|:.::::   ||.|:.
  Rat   356 DTAIENGQHYWEVKAQKDCKSYSV------GVAYKTLGKFDQLGKTNTSWCIHVN---SWLQNTF 411

  Fly   666 -SIHERRVEG-GITTGSTIGVLLDLERHTLSFLVNEMPQGSVAFRDLY-GVFYPAVSINRGVTLT 727
             :.|..:|:. .:.....|||..|.:...|||......|...:|:..: ....|...:..| .|:
  Rat   412 AAKHNNKVKALDVPVPEKIGVFCDFDGGQLSFYDAHSKQLLYSFKTKFTQPVVPGFMVWCG-GLS 475

  Fly   728 MHTAMDAP 735
            :.|.|..|
  Rat   476 LSTGMQVP 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trim9	NP_001188786.1	RING-HC_TRIM9_like_C-I	2..37	CDD:319490
		zf-B_box	250..291	CDD:306989
		ClassIIa_HDAC_Gln-rich-N	298..420	CDD:330228	27/125 (22%)
		FN3	472..564	CDD:238020	34/113 (30%)
		SPRY_PRY_TRIM67_9	561..735	CDD:293947	46/230 (20%)
Fsd1l	XP_008761944.1	iSH2_PI3K_IA_R	4..130	CDD:304922	28/138 (20%)
		FN3	165..265	CDD:238020	34/110 (31%)
		SPRY_PRY_FSD1	270..484	CDD:293958	45/224 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24099
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010