Protein Alignment Trim9 and Trim46

DIOPT Version :9

• Sequence 1: NP_001188786.1
• Gene: Trim9 / 34453
• FlyBaseID: FBgn0051721
• Length: 740
• Species: Drosophila melanogaster
• Sequence 2: NP_001382034.1
• Gene: Trim46 / 310641
• RGDID: 1305993
• Length: 759
• Species: Rattus norvegicus
• Alignment Length: 811
• Identity: 193/811 - (23%)
• Similarity: 297/811 - (36%)
• Gaps: 225/811 - (27%)

  Fly     1 MEDELRCPTCKQLYANPVLLPCFHALCLGCALDIQTPYSPGSALPGAVNGAGAASAAGHNGLHGN 65
            ||.||.||.|:::|..|::|||.|.:|..||.::                      .|..|..|:
  Rat    27 MEKELLCPVCQEMYKQPLVLPCTHNVCQACAREV----------------------LGQQGYIGH 69

  Fly    66 GGGAGGGAAAPVTNPNGPGTRHSSHSSAASTASSNTGSESVTSDQDQSDKVSIFSEADSGVVCCS 130
            ||.       |.:.|..|       :|..||.|... |.......|:.|:
  Rat    70 GGD-------PSSEPTSP-------ASTPSTRSPRL-SRRTLPKPDRLDR--------------- 104

  Fly   131 NTSRPVSYAGTGLLPGVGNVVAPPGAAYCLT----CPLCRKLVFFDDGGVRNLPTYRAMEAIVDR 191
                 :..:|.|..||     ...||.:..|    ||.|:..|...:.|:..|.....:|.:|:|
  Rat   105 -----LLKSGFGTYPG-----RKRGALHPQTILFPCPACQGDVELGERGLSGLFRNLTLERVVER 159

  Fly   192 FCARE------ALRCQMCETDPKVASLICEQCEIRYCDACRELTHPARGPLAKHTLVKPRGAAQQ 250
            :  |:      |:.||:|:..|..|:..|.:|...:|:.|.:|.||.....|:|....|..:.:.
  Rat   160 Y--RQSVSVGGAILCQLCKPPPLEATKGCSECRATFCNECFKLFHPWGTQKAQHEPTLPTLSFRP 222

  Fly   251 RESVCGEHEETLSQYCLSCKAPACGLCIGELRHQAHDVQSINVTCKAQKTELSHNLQQLSEKARS 315
            :..:|.:|:|.::.||.:|:...|.||.....|..|.:..:....:|.|.:|
  Rat   223 KGLMCPDHKEEVTHYCKTCQRLVCQLCRVRRTHSGHKITPVLSAYQALKDKL------------- 274

  Fly   316 TTEFIQRLKGMSDKV-TESCMEFERLVHAQ-------------CEALIQAIHDRREYLLEAIRMD 366
             |:.:..:.|..|.| |:.|...|.:.|.:             ...|...:.::|..||:||...
  Rat   275 -TKSLAYILGNQDTVQTQICELEETIRHTEVSGQQAKEEVSQLVRGLGAVLEEKRSSLLQAIEEC 338

  Fly   367 KDTKIRILKDQ----QSNCTGKLQQTTGLIQFCIEALKETDSAAFLQVGSMLINRVTNTDMTWHQ 427
            :..::..|..|    ||...|     :||:.:..|.|||||...|:|....|.||:.
  Rat   339 QQERLSRLSAQIHEHQSLLDG-----SGLVGYAQEVLKETDQPCFVQAAKQLHNRIA-------- 390

  Fly   428 EVTNAAPRVSPIVDLT-----LDDAALARAIDNLNFIQMRAVKDGDERCPAAPMTPTILPSDCSA 487
            ..|.|.....|....:     ||.....:.:..|||:          |.|.||    ::.:..:.
  Rat   391 RATEALQTFRPAASSSFRHCQLDVGREMKLLTELNFL----------RVPEAP----VIDTQRTF 441

  Fly   488 ENNSVTVAWQPPNHS------FVEGYVLELDDGSG---GEFREVYCGKETICTVDGLHFNSMYNA 543
            ..:.:.:.|:.|.||      .||....::....|   .:.||...|  |...::.....|:|..
  Rat   442 AYDQIFLCWRLPPHSPPAWHYTVEFRRTDVPAQPGPTRWQRREEVRG--TSALLENPDTGSVYVL 504

  Fly   544 RVKAFNSAGEGEYSELIGLQT--AEVAWFTFDPVLSGGAGSGLIFSKNNATV-SVEGWE------ 599
            ||:..|.||.|||||.:.|.|  |.|..|..|. ..|.:...|..||:...| |:.|..
  Rat   505 RVRGCNKAGYGEYSEDVHLHTPPAPVLHFFLDG-RWGASRERLAISKDQRAVRSIPGLPLLLAAE 568

  Fly   600 ------H---RVALGSVGFSRGVHYWEFTIDNYTADTDPAFGVARIDVARNKMLGKDEKSFAMYI 655
                  |   .|.||.|..::|..||...:       |||..:.::.|.....|   ::||....
  Rat   569 RLLTGCHLSVDVVLGDVAVTQGRSYWACAV-------DPASYLVKVGVGLESKL---QESFQGAP 623

  Fly   656 DRQRSWFQHNSIHERRVE-----------------GGITTGS----------------------- 680
            |.....:..:|.|:...|                 |.|..||
  Rat   624 DVISPRYDPDSGHDSGAEDAAVEALPPFAFLTIGMGKILLGSGASSNAGLTGRDGPAASCTVPLP 688

  Fly   681 -TIGVLLDLERHTLSFLVNEMPQGSVAFRDL 710
             .:|:.||.||..:|||      .:|:||.|
  Rat   689 PRLGICLDYERGRVSFL------DAVSFRGL 713

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trim9	NP_001188786.1	RING-HC_TRIM9_like_C-I	2..37	CDD:319490	15/34 (44%)
		zf-B_box	250..291	CDD:306989	11/40 (28%)
		ClassIIa_HDAC_Gln-rich-N	298..420	CDD:330228	34/139 (24%)
		FN3	472..564	CDD:238020	27/100 (27%)
		SPRY_PRY_TRIM67_9	561..735	CDD:293947	48/209 (23%)
Trim46	NP_001382034.1	Required for proximal axon localization, axon formation and migration. /evidence=ECO:0000250|UniProtKB:Q7TNM2	1..166		48/202 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	67..98		11/45 (24%)
		Required for microtubule association, proximal axon localization and axon formation. /evidence=ECO:0000250|UniProtKB:Q7TNM2	411..429		5/27 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24099
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010