DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trim9 and Trim36

DIOPT Version :9

Sequence 1:	NP_001188786.1	Gene:	Trim9 / 34453	FlyBaseID:	FBgn0051721	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_001099617.1	Gene:	Trim36 / 291597	RGDID:	1308714	Length:	729	Species:	Rattus norvegicus

Alignment Length:	818	Identity:	184/818 - (22%)
Similarity:	300/818 - (36%)	Gaps:	198/818 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEDELRCPTCKQLYANPVLLPCFHALCLGCALDIQTPYSPGSALPGAVNGAGAASAAGHNGLHGN 65
            :|.||.||.||:|:.:|::|||.|::|..|..::..      :|..:.|...:.|
  Rat    27 IEKELICPACKELFTHPLILPCQHSVCHKCVKELLL------SLDDSFNDVASDS---------- 75

  Fly    66 GGGAGGGAAAPVTNPNGPGTRHSSHSSAASTASSNTGSESVTSDQDQSDKVSIFSEADSGVVCCS 130
                        :|.:.|..|.:|.|                  .|:.||::     ..|....|
  Rat    76 ------------SNQSSPRLRLTSPS------------------MDKIDKIN-----RPGWKRNS 105

  Fly   131 NTSRPVSYAGTGLLPGVGNVVAPPGAAYCLTCPLCRKLVFFDDGGVRNLPTYRAMEAIVDRF--- 192
            .|.||..:                      .||.|...|...:.||..|.....:|.||:|:
  Rat   106 LTPRPTMF----------------------PCPGCEHDVDLGERGVSGLFRNFTLETIVERYRQA 148

  Fly   193 -CAREALRCQMCETDPKVASLICEQCEIRYCDACRELTHPARGPLAKHTLVKPRGAAQQRESVCG 256
             .|..|:.|.:|:..|:.::..|..|...||:.|.::.||.....|:|..|.|....:.:..:|.
  Rat   149 ARAATAIMCDLCKPPPQESTKSCMDCSASYCNECFKIYHPWGTVKAQHEYVGPTTNFRPKILMCP 213

  Fly   257 EHE-ETLSQYCLSCKAPACGLCIGELRHQAHDVQSINVTCKAQKTELSHNLQQLSEKARSTTEFI 320
            ||| |.::.||..|:.|.|.||.....|..|.|.:::...|..|.:||.::..|..|.......|
  Rat   214 EHETERINMYCELCRRPVCHLCKLGGNHSNHRVTTMSSAYKTLKEKLSKDIDFLIGKESQVKSQI 278

  Fly   321 QRLKGMSDKVTESC----MEFERLVHAQCEALIQAIHDRREYLLEAIRMDKDTKIRILKDQQSNC 381
            ..| .:..|.|| |    .:.|.|.|  .|.|.:.:.||:..:|:||...|..::.....|....
  Rat   279 SEL-NLLMKETE-CNGERAKEEALAH--FEKLFEILEDRKSSVLKAIDASKKLRLDKFHTQMEEY 339

  Fly   382 TGKLQQTTGLIQFCIEALKETDSAAFLQVGSMLINRVTNTDMTWHQEVTNAAPRVSPIVDLTLDD 446
            .| |.:..||:.:..|.|||||.:.|:|....|..|:        |:.|.:.....|....:.:|
  Rat   340 QG-LLENNGLVGYAQEVLKETDQSCFVQTAKQLHLRI--------QKATESLKSFRPAAQASFED 395

  Fly   447 AAL-----ARAIDNLNFIQMRAVKDGDERCPAAPMTPTILPSDCSAENNSVTVAWQPPNHSFVEG 506
            ..:     ...:..|:|.     ..|.:       .|.|........||:: :.|..|.....:.
  Rat   396 YVVNISKQTEVLGELSFF-----SSGID-------IPEINEEQSKVYNNAL-IDWHHPEKDKADS 447

  Fly   507 YVLELDDGSGGEFREVYCGKETIC-----------TVDGLHFNSMYNARVKAFNSAGEGEYSELI 560
            |||        |:|::...:|.|.           .|..|..||.|..||:|:..:.....|..:
  Rat   448 YVL--------EYRKINRDEEMISWNEIEVHGTSKVVSNLESNSPYAFRVRAYRGSICSPCSREL 504

  Fly   561 GLQT--AEVAWFTFDPVLSGGAGSGLIFSKNNATVSVEGWEHRVA---------------LGSVG 608
            .|.|  |.|..|.||..........|:..|.:...|..|:...:|               :|.||
  Rat   505 VLHTPPAPVFSFLFDEKCGYNTEHLLLNLKRDRVESRAGFNVLLAAERIQVGHYTSLDYIIGDVG 569

  Fly   609 FSRGVHYWEFTIDNYTADTDPAFGVARIDVARNKML-------------------GKDEKSFAMY 654
            .::|.|:|...::.|:.       :.::.||.:..|                   |.|..|...|
  Rat   570 ITKGKHFWACRVEPYSY-------LVKVGVASSDKLQEWLRSPRDAASPRYEQDSGHDSGSEDAY 627

  Fly   655 IDR----------QRSWF-----QHNSIHERRVEGGITTGSTIGVLLDLERHTLSFLVNEMPQGS 704
            .|.          .:.:|     ..::..|.||   :...::||:.||.::..:||.  :|....
  Rat   628 FDSSQPFTLVTIGMKKFFIPKSPTSSNEPENRV---LPMPTSIGIFLDCDKGKVSFY--DMDHMK 687

  Fly   705 VAFR---DLYGVFYPAVSINRGVTLTMHTAMDAPKMDY 739
            ..:.   |.....|||.::.....:.:...:.|..::|
  Rat   688 CLYERQVDCSHTMYPAFALMGSGGIQLEETITAKYLEY 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trim9	NP_001188786.1	RING-HC_TRIM9_like_C-I	2..37	CDD:319490	15/34 (44%)
		zf-B_box	250..291	CDD:306989	15/41 (37%)
		ClassIIa_HDAC_Gln-rich-N	298..420	CDD:330228	37/125 (30%)
		FN3	472..564	CDD:238020	23/102 (23%)
		SPRY_PRY_TRIM67_9	561..735	CDD:293947	42/227 (19%)
Trim36	NP_001099617.1	zf-RING_UBOX	33..>61	CDD:290181	12/27 (44%)
		BBOX	211..249	CDD:237988	15/37 (41%)
		iSH2_PI3K_IA_R	256..380	CDD:304922	38/136 (28%)
		FN3	431..494	CDD:214495	19/71 (27%)
		SPRY_PRY_TRIM36	516..719	CDD:293951	38/214 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I11869
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24099
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010