Protein Alignment Trim9 and TRIM42

DIOPT Version :10

• Sequence 1: NP_001188786.1
• Gene: Trim9 / 34453
• FlyBaseID: FBgn0051721
• Length: 740
• Species: Drosophila melanogaster
• Sequence 2: XP_011511042.1
• Gene: TRIM42 / 287015
• HGNCID: 19014
• Length: 727
• Species: Homo sapiens
• Alignment Length: 726
• Identity: 138/726 - (19%)
• Similarity: 218/726 - (30%)
• Gaps: 281/726 - (38%)

  Fly     3 DELRCPTCKQLYANPVLLPCFHALCLGCALDIQTPYSPGSALPGAVNGAGAASAAGHNGLHGNGG 67
            :.|.||.|.:|..:..:|||.|:||..|...:|
Human   142 NHLNCPMCSRLRLHSFMLPCNHSLCEKCLRQLQ-------------------------------- 174

  Fly    68 GAGGGAAAPVTNPNGPGTRHSSHSSAASTASSNTGSESVTSDQDQSDKVSIFSEADSGVVCCSNT 132
                              :|:                .||.:
Human   175 ------------------KHA----------------EVTEN----------------------- 182

  Fly   133 SRPVSYAGTGLLPGVGNVVAPPGAAYCLTCPLCRKLVFFDDGGVRNLPTYRAMEAIVDRFCAREA 197
                                    .:.|.||:|.:...........||.......:..|:.....
Human   183 ------------------------FFILICPVCDRSHCMPYSNKMQLPENYLHGRLTKRYMQEHG 223

  Fly   198 ------------LRCQMCETDPKVASLICEQCEIRYCDACRELTHPARGPLAKHTLVKPRGAAQQ 250
                        :.||:|. :.::|...|..|.:..|:.|.:..| :...:..|..| ...|.:|
Human   224 YLKWRFDRSSGPILCQVCR-NKRIAYKRCITCRLNLCNDCLKAFH-SDVAMQDHVFV-DTSAEEQ 285

  Fly   251 RESVCGEHEET-LSQYCLSCKAPACGLCIGELRHQAHDVQSINVTCKAQKTELSHNLQQLSEKAR 314
            .|.:|..|..: :.:||.:.....|..|.... |..||..|:...|              ||:|.
Human   286 DEKICIHHPSSRIIEYCRNDNKLLCTFCKFSF-HNGHDTISLIDAC--------------SERAA 335

  Fly   315 STTEFIQRLKGMSDKVTESCMEFERLVH---AQCEALIQAIHDRREYL-LEAIRMDKDTKIRILK 375
            |....|.:.|.:..::....|||..|.:   |..||..:.|  |..:| |.:|..:|:   :|:.
Human   336 SLFSAIAKFKAVRYEIDNDLMEFNILKNSFKADKEAKRKEI--RNGFLKLRSILQEKE---KIIM 395

  Fly   376 DQQSN---------------CTGKLQQTTGLIQFCIEALKETDSAAFLQVGSMLINRVTNTDMTW 425
            :|..|               .|.|:.:..|||.:..||||||...||||...:|::::.:...|.
Human   396 EQIENLEVSRQKEIEKYVYVTTMKVNEMDGLIAYSKEALKETGQVAFLQSAKILVDQIEDGIQTT 460

  Fly   426 HQEVTNAAPRVSPIVDLTLDDAALARAIDNL---------------------------------- 456
            ::  .:...|:..|..:.||...|:.||..|
Human   461 YR--PDPQLRLHSINYVPLDFVELSSAIHELFPTGPKKVRSSGDSLPSPYPVHSETMIARKVTFS 523

  Fly   457 ------NFIQMRA------------VKDGDERCPAAPMTPTILPSD------------CSAENNS 491
                  ..|..|:            .|.|.|.|..|.......|:|            .|.:|:|
Human   524 THSLGNQHIYQRSSSMLSFSNTDKKAKVGLEACGRAQSATPAKPTDGLYTYWSAGADSQSVQNSS 588

  Fly   492 VTVAWQPPNHSFVEGYV-------------------------LELDDGSGGEFREV--------- 522
            ....|    :||.:|.|                         .|..|....||.||
Human   589 SFHNW----YSFNDGSVKTPGPIVIYQTLVYPRAAKVYWTCPAEDVDSFEMEFYEVITSPPNNVQ 649

  Fly   523 --YCGK-----ETICTVDGLHFNSMYNARVKAFNSAGEGEYSELIGLQTAEVAWFTFDPVLSGGA 580
              .||:     :....:..|..|:.|..:|:|.|..|.|::|::...........:|.|..:.||
Human   650 MELCGQIRDIMQQNLELHNLTPNTEYVFKVRAINDNGPGQWSDICKCWDHRDERLSFPPHPNQGA 714

  Fly   581 GSGLIFSKNNA 591
             .||: .|:||
Human   715 -HGLV-RKSNA 723

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trim9	NP_001188786.1	RING-HC_TRIM9-like_C-I	2..>35	CDD:438238	12/31 (39%)
		Bbox1_TRIM9-like_C-I	199..244	CDD:380861	11/44 (25%)
		Bbox2_TRIM9-like	255..291	CDD:380822	9/36 (25%)
		CC_brat-like	298..420	CDD:475168	38/140 (27%)
		FN3	472..564	CDD:238020	28/144 (19%)
		SPRY_PRY_TRIM67_9	561..735	CDD:293947	9/31 (29%)
TRIM42	XP_011511042.1	NosR	<4..81	CDD:443108
		RING-HC_TRIM42_C-III	139..196	CDD:438240	20/166 (12%)
		Bbox_SF	235..280	CDD:469587	11/47 (23%)
		Bbox2_TRIM42_C-III	287..326	CDD:380840	10/39 (26%)
		CC_brat-like	<369..452	CDD:475168	27/87 (31%)
		FN3	612..692	CDD:238020	16/79 (20%)