DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trim9 and Trim36

DIOPT Version :9

Sequence 1:	NP_001188786.1	Gene:	Trim9 / 34453	FlyBaseID:	FBgn0051721	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_849203.2	Gene:	Trim36 / 28105	MGIID:	106264	Length:	729	Species:	Mus musculus

Alignment Length:	829	Identity:	182/829 - (21%)
Similarity:	301/829 - (36%)	Gaps:	220/829 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEDELRCPTCKQLYANPVLLPCFHALCLGCALDIQTPYSPGSALPGAVNGAGAASAAGHNGLHGN 65
            :|.||.||.||:|:.:|::|||.|::|..|..::..      :|..:.|...:.|
Mouse    27 IEKELICPACKELFTHPLILPCQHSVCHKCVKELLL------SLDDSFNDVASDS---------- 75

  Fly    66 GGGAGGGAAAPVTNPNGPGTRHSSHSSAASTASSNTGSESVTSDQDQSDKVSIFSEADSGVVCCS 130
                        :|.:.|..|.:|.|                  .|:.||::     ..|....|
Mouse    76 ------------SNQSSPRLRLTSPS------------------MDKIDKIN-----RPGWKRNS 105

  Fly   131 NTSRPVSYAGTGLLPGVGNVVAPPGAAYCLTCPLCRKLVFFDDGGVRNLPTYRAMEAIVDRF--- 192
            .|.||.::                      .||.|...|...:.||..|.....:|.||:|:
Mouse   106 LTPRPTTF----------------------PCPGCEHDVDLGERGVSGLFRNFTLETIVERYRQA 148

  Fly   193 -CAREALRCQMCETDPKVASLICEQCEIRYCDACRELTHPARGPLAKHTLVKPRGAAQQRESVCG 256
             .|..|:.|.:|:..|:.::..|..|...||:.|.::.||.....|:|..|.|....:.:..:|.
Mouse   149 ARAATAIMCDLCKPPPQESTKSCMDCSASYCNECFKIYHPWGTVKAQHEYVGPTTNFRPKVLMCP 213

  Fly   257 EHE-ETLSQYCLSCKAPACGLCIGELRHQAHDVQSINVTCKAQKTELSHNLQQLSEKARSTTEFI 320
            ||| |.::.||..|:.|.|.||.....|..|.|.:::...|..|.:||.::..|..|.......|
Mouse   214 EHETERINMYCELCRRPVCHLCKLGGNHSNHRVTTMSSAYKTLKEKLSKDIDFLIGKESQVKSQI 278

  Fly   321 QRLKGMSDKVTESC----MEFERLVHAQCEALIQAIHDRREYLLEAIRMDKDTKIRILKDQQSNC 381
            ..| .:..|.|| |    .:.|.|.|  .|.|.:.:.||:..:|:||...|..::.....|....
Mouse   279 SEL-NLLMKETE-CNGERAKEEALAH--FEKLFEILEDRKSSVLKAIDASKKLRLDKFHTQMEEY 339

  Fly   382 TGKLQQTTGLIQFCIEALKETDSAAFLQVGSMLINRVTNTDMTWHQEVTNAAPRVSPIVDLTLDD 446
            .| |.:..||:.:..|.|||||.:.|:|....|..|:        |:.|.:.....|....:.:|
Mouse   340 QG-LLENNGLVGYAQEVLKETDQSCFVQTAKQLHLRI--------QKATESLKSFRPAAQASFED 395

  Fly   447 AAL-----ARAIDNLNFIQMRAVKDGDERCPAAPMTPTILPSDCSAENNSVTVAWQPPNHSFVEG 506
            ..:     ...:..|:|.     ..|.:       .|.|........||:: :.|..|.....:.
Mouse   396 YVVNISKQTEVLGELSFF-----SSGID-------IPEINEEQSKVYNNAL-IDWHHPEKDKADS 447

  Fly   507 YVLELDDGSGGEFREVYCGKETIC-----------TVDGLHFNSMYNARVKAFNSAGEGEYSELI 560
            |||        |:|::...:|.|.           .|..|..||.|..||:|:..:.....|..:
Mouse   448 YVL--------EYRKINRDEEMISWNEIEVHGTSKVVSNLESNSPYAFRVRAYRGSICSPCSREL 504

  Fly   561 GLQT--AEVAWFTFDPVLSGGAGSGLIFSKNNATVSVEGWEHRVA---------------LGSVG 608
            .|.|  |.|..|.||..........|:..|.:...|..|:...:|               :|.||
Mouse   505 ILHTPPAPVFSFLFDEKCGYNTEHLLLNLKRDRVESRAGFNVLLAAERIQVGHYTSLDYIIGDVG 569

  Fly   609 FSRGVHYWEFTIDNYTADTDPAFGVARIDVARNKMLGKDEKSFAMYIDRQRSW-----------F 662
            .::|.|:|...::.|:.       :.::.||.:              |:.:.|           :
Mouse   570 VTKGKHFWACRVEPYSY-------LVKVGVASS--------------DKLQEWLRSPRDAASPRY 613

  Fly   663 QHNSIHERRVEGG----------ITTG------------------------STIGVLLDLERHTL 693
            :.:|.|:...|..          :|.|                        ::||:.||.::..:
Mouse   614 EQDSGHDSGSEDACFDSSQPFTLVTIGMKKFFIPKSPTSSNEPENRVLPMPTSIGIFLDCDKGKV 678

  Fly   694 SFLVNEMPQGSVAFR---DLYGVFYPAVSINRGVTLTMHTAMDAPKMDY 739
            ||.  :|......:.   |.....|||.::.....:.:..|:.|..::|
Mouse   679 SFY--DMDHMKCLYERQVDCSHTMYPAFALMGSGGIQLEEAITAKYLEY 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trim9	NP_001188786.1	RING-HC_TRIM9_like_C-I	2..37	CDD:319490	15/34 (44%)
		zf-B_box	250..291	CDD:306989	15/41 (37%)
		ClassIIa_HDAC_Gln-rich-N	298..420	CDD:330228	37/125 (30%)
		FN3	472..564	CDD:238020	23/102 (23%)
		SPRY_PRY_TRIM67_9	561..735	CDD:293947	40/238 (17%)
Trim36	NP_849203.2	zf-RING_UBOX	33..>61	CDD:290181	12/27 (44%)
		BBOX	211..249	CDD:237988	15/37 (41%)
		iSH2_PI3K_IA_R	256..380	CDD:304922	38/136 (28%)
		FN3	431..494	CDD:214495	19/71 (27%)
		SPRY_PRY_TRIM36	516..719	CDD:293951	36/225 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	606..626		3/19 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I12046
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24099
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010