DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trim9 and Mid2

DIOPT Version :9

Sequence 1:	NP_001188786.1	Gene:	Trim9 / 34453	FlyBaseID:	FBgn0051721	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_001345296.1	Gene:	Mid2 / 23947	MGIID:	1344333	Length:	735	Species:	Mus musculus

Alignment Length:	778	Identity:	188/778 - (24%)
Similarity:	289/778 - (37%)	Gaps:	217/778 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEDELRCPTCKQLYANPVLLPCFHALCLGCALDIQTPYSPGSALPGAVNGAGAASAAGHNGLHGN 65
            :|.||.||.|.:|:.:|:||||.|:||..||
Mouse    24 LESELTCPICLELFEDPLLLPCAHSLCFSCA---------------------------------- 54

  Fly    66 GGGAGGGAAAPVTNPNGPGTRHSSHSSAASTASSNTGSESVTSDQDQSDKVSIFSEADSGVVCCS 130
                                    |....|:.||....|.:|:.|
Mouse    55 ------------------------HRILVSSCSSGESIEPITAFQ-------------------- 75

  Fly   131 NTSRPVSYAGTGLLPGVGNVVAPPGAAYCLTCPLCRKLVFFDDGGVRNLPTYRAMEAIVDRF--- 192
                                           ||.||.::..:..|:..|.....::.|:|||
Mouse    76 -------------------------------CPTCRYVISLNHRGLDGLKRNVTLQNIIDRFQKA 109

  Fly   193 ----------------------CAREALRCQMCETD-PKVASLICEQCEIRYCDACRELTHPARG 234
                                  .:.|.:.||.||.| |:.|...|..||:.|||.|...|||.:.
Mouse   110 SVSGPNSPSESRRERTYRPSSAMSSERIACQFCEQDPPRDAVKTCITCEVSYCDRCLRATHPNKK 174

  Fly   235 PLAKHTLVKPRGAAQQRESVCGEHE-ETLSQYCLSCKAPACGLC--IGELRHQAHDVQSINVTCK 296
            |...|.||:|......|...|.:|| |.::.||:|.....|.||  :|  ||:.|.|.|:|...:
Mouse   175 PFTSHRLVEPVSDTHLRGITCLDHENEKVNMYCVSDDQLICALCKLVG--RHRDHQVASLNDRFE 237

  Fly   297 AQKTELSHNLQQLSEKARSTTEFIQRLKGMSDKVTESCMEFERLVHAQCEALIQAIHDRREYLLE 361
            ..|..|..||..|.::.......:.:|..:..:|..:....|..:..:|:.|::.|..|::.:..
Mouse   238 KLKQTLEMNLTNLVKRNSELENQMAKLIQICQQVEVNTAMHEAKLMEECDELVEIIQQRKQMIAV 302

  Fly   362 AIRMDKDTKIRILKDQQSNCTGKLQQTTGLIQFCIEALKETDSAAFLQVGSMLINRVTNTDMTWH 426
            .|:..|..|:|.|..|.:||...|:::|.||......|||.|.|.|||....:..||.
Mouse   303 KIKETKVMKLRKLAQQVANCRQCLERSTVLINQAEHILKENDQARFLQSAKNIAERVA------- 360

  Fly   427 QEVTNAAPRVSPIVDLTLDDAALARAIDNLNFIQMRAVKDGDERCPAAPMTPTILPSDCSAENNS 491
              :..|:.:|. |.|:..:||....|:|   |.:.:.:.:|.:.. .||..|:|....|:|.:::
Mouse   361 --MATASSQVL-IPDINFNDAFENFALD---FSREKKLLEGLDYL-TAPNPPSIREELCTASHDT 418

  Fly   492 VTVAWQPPNHSFVEGYVLELDDGSG------------GEFREVYCGKETI-C------------- 530
            :||.|...:...:..|.|:....:|            |.:.|:...||.: |
Mouse   419 ITVHWISDDEFSISSYELQYTIFTGQANFISKSWCSWGLWPEIRKCKEAVSCSRLAGAPRGLYNS 483

  Fly   531 ---------------TVDGLHFNSMYNARVKAFNSAGEGEYSELIGLQTAEVAWFTFDPVLSGG- 579
                           ||.||...:.|...|||.|.|| ...||...|:|.... |..||.::..
Mouse   484 VDSWMIVPNIKQNHYTVHGLQSGTRYIFIVKAINQAG-SRNSEPTRLKTNSQP-FKLDPKMTHKK 546

  Fly   580 ---AGSGLIFSKNNATVSVEGWEHRV-------ALGSVGFSRGVHYWEFTIDNYTADTDPAFGVA 634
               :..||...|:.:::.......|.       |.|::....|.||||..:.   :.|..|.|:|
Mouse   547 LKISNDGLQMEKDESSLKKSHTPERFSGTGCYGAAGNIFIDSGCHYWEVVMG---SSTWYAIGIA 608

  Fly   635 RIDVARNKMLGKDEKSFAMYIDRQRSWF--QHNSIHERRVEGGITTGSTIGVLLDLERHTLSF 695
            .....:|:.:||:..|:.  ..|..|.|  :||: .|..|:..... ..:|||||.:.:.|||
Mouse   609 YKSAPKNEWIGKNASSWV--FSRCNSNFVVRHNN-KEMLVDVPPQL-KRLGVLLDYDNNMLSF 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trim9	NP_001188786.1	RING-HC_TRIM9_like_C-I	2..37	CDD:319490	17/34 (50%)
		zf-B_box	250..291	CDD:306989	16/43 (37%)
		ClassIIa_HDAC_Gln-rich-N	298..420	CDD:330228	34/121 (28%)
		FN3	472..564	CDD:238020	31/132 (23%)
		SPRY_PRY_TRIM67_9	561..735	CDD:293947	39/148 (26%)
Mid2	NP_001345296.1	RING-HC_MID2	30..82	CDD:319668	25/160 (16%)
		RING-HC finger (C3HC4-type)	30..79	CDD:319668	23/157 (15%)
		BBOX	195..232	CDD:197662	15/38 (39%)
		BBC	239..364	CDD:128778	34/133 (26%)
		FN3	401..531	CDD:238020	31/130 (24%)
		SPRY_PRY_TRIM1	536..705	CDD:293974	37/139 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24099
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010