DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trim9 and TRIM2

DIOPT Version :9

Sequence 1:	NP_001188786.1	Gene:	Trim9 / 34453	FlyBaseID:	FBgn0051721	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_001362417.1	Gene:	TRIM2 / 23321	HGNCID:	15974	Length:	802	Species:	Homo sapiens

Alignment Length:	823	Identity:	144/823 - (17%)
Similarity:	259/823 - (31%)	Gaps:	273/823 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LRCPTCKQLYANPVLLPCFHALCLGCALDIQTPYSPGSALPGAVNGAGAASAAGHNGLHGNGGGA 69
            |.|..|.:.|.||.:|||.|..|..|..:    |.|..:|..:.......|.....|:
Human    48 LICSICLERYKNPKVLPCLHTFCERCLQN----YIPAHSLTLSCPVCRQTSILPEKGV------- 101

  Fly    70 GGGAAAP----VTN-----PNGPGTRHSSHSSAASTASSNTGSESVTSDQDQSDKVSIFSEADSG 125
               ||..    :||     ...||          |.|..::..|:||:           ..|...
Human   102 ---AALQNNFFITNLMDVLQRTPG----------SNAEESSILETVTA-----------VAAGKP 142

  Fly   126 VVCCSNTSRPVSYAGTGLLPGVGN----VVAPPGAAYCLTCPLCRKLVFFDDGGVRNLPTYRAME 186
            :.|.::.....|:|....|  |.|    |:.||..:..|              |::.:..|
Human   143 LSCPNHDGNRQSFAVVPRL--VSNPWPQVILPPWPSKVL--------------GLQVMEFY---- 187

  Fly   187 AIVDRFCAREALRCQMCETDPKVASLICEQCEIRYCDACRELTHPARGPLAKHTLVKPRGAAQQR 251
                         ||.|||      .:|.:|              ..|..|:|..|..:...:|
Human   188 -------------CQSCET------AMCREC--------------TEGEHAEHPTVPLKDVVEQ- 218

  Fly   252 ESVCGEHEETLSQYCLSCKAPACGLCIGELRHQAHDVQSINVTCKAQKTELSHNLQQLSEKARST 316
                                           |:|        :.:.|...::..|.::....:..
Human   219 -------------------------------HKA--------SLQVQLDAVNKRLPEIDSALQFI 244

  Fly   317 TEFIQRLKGMSDKVTESCMEFERLVHAQCEALIQAIHDRREYLLEAIRMDKDTKIRILKDQQSNC 381
            :|.|.:|......:.:.       :|:..:.|.:.::.|:..||..:.::...|.::|:.|....
Human   245 SEIIHQLTNQKASIVDD-------IHSTFDELQKTLNVRKSVLLMELEVNYGLKHKVLQSQLDTL 302

  Fly   382 TGKLQQTTGLIQFCIEALK---ETDSAAFLQVGSMLINRVTNTDMTWHQEVTNAAPRVSPIVDLT 443
            ....:.......|..:||.   ||:.....:..|..:|.:.:.|...|       ||.:..:|..
Human   303 LQGQESIKSCSNFTAQALNHGTETEVLLVKKQMSEKLNELADQDFPLH-------PRENDQLDFI 360

  Fly   444 LDDAALARAIDNL------NFIQMRAVKDGD---ERCPAAPMTPTILPSD-----CSAENNSVTV 494
            ::...|.::|.||      |.:....|..|:   :.....||:.||...|     |...|..:|.
Human   361 VETEGLKKSIHNLGTILTTNAVASETVATGEGLRQTIIGQPMSVTITTKDKDGELCKTGNAYLTA 425

  Fly   495 AWQPPNHSFVEGYVLELDDGSGGEFREVYCGKETICTVDGLHFNSMYNARVKAFNSAGEGEYSEL 559
            ....|:.|..:|.:|   |...|.:..:|..::          ...:...::.::....|...:|
Human   426 ELSTPDGSVADGEIL---DNKNGTYEFLYTVQK----------EGDFTLSLRLYDQHIRGSPFKL 477

  Fly   560 IGLQTAEVAWFTFDPVLSG------GAGSGLIFS---KNNATVSVEGWEHR--------VALGSV 607
            ..:::|:|:     |...|      ..|||.:..   |..|::...|....        ..:|:.
Human   478 KVIRSADVS-----PTTEGVKRRVKSPGSGHVKQKAVKRPASMYSTGKRKENPIEDDLIFRVGTK 537

  Fly   608 GFSRGVHYWEFT-IDNYTADTD-----------------------PAFGVARIDVARNKMLGKDE 648
            |.::|    ||| :....|.|:                       ..||:      |.:..|:.:
Human   538 GRNKG----EFTNLQGVAASTNGKILIADSNNQCVQIFSNDGQFKSRFGI------RGRSPGQLQ 592

  Fly   649 KSFAMYI---------DRQRSW---FQHNSIHERRVEGGITTGSTIGVLLDLERHTLSFLVNE-- 699
            :...:.:         |....|   |..:...:.::..|...|.. ||.:|...|.:  :|:.
Human   593 RPTGVAVHPSGDIIIADYDNKWVSIFSSDGKFKTKIGSGKLMGPK-GVSVDRNGHII--VVDNKA 654

  Fly   700 ------MPQGSVAF---------RDLYGVFYPAVSINRGVTLT 727
                  .|.|.:..         |...|..:.||:.|..:.:|
Human   655 CCVFIFQPNGKIVTRFGSRGNGDRQFAGPHFAAVNSNNEIIIT 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trim9	NP_001188786.1	RING-HC_TRIM9_like_C-I	2..37	CDD:319490	12/31 (39%)
		zf-B_box	250..291	CDD:306989	3/40 (8%)
		ClassIIa_HDAC_Gln-rich-N	298..420	CDD:330228	20/124 (16%)
		FN3	472..564	CDD:238020	17/96 (18%)
		SPRY_PRY_TRIM67_9	561..735	CDD:293947	40/237 (17%)
TRIM2	NP_001362417.1	RAD18	33..>136	CDD:227719	27/111 (24%)
		RING-HC_TRIM2	47..92	CDD:319681	15/47 (32%)
		Bbox_SF	142..214	CDD:381767	23/124 (19%)
		BBC	219..345	CDD:128778	22/140 (16%)
		IG_FLMN	383..479	CDD:214720	19/108 (18%)
		NHL_TRIM2_like	529..802	CDD:271330	30/182 (16%)
		NHL repeat	547..586	CDD:271330	5/44 (11%)
		NHL repeat	594..633	CDD:271330	4/38 (11%)
		NHL repeat	636..672	CDD:271330	7/38 (18%)
		NHL repeat	680..720	CDD:271330	5/18 (28%)
		NHL repeat	729..769	CDD:271330
		NHL repeat	772..798	CDD:271330
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910