Protein Alignment Trim9 and Trim25

DIOPT Version :10

• Sequence 1: NP_001188786.1
• Gene: Trim9 / 34453
• FlyBaseID: FBgn0051721
• Length: 740
• Species: Drosophila melanogaster
• Sequence 2: NP_033572.2
• Gene: Trim25 / 217069
• MGIID: 102749
• Length: 634
• Species: Mus musculus
• Alignment Length: 845
• Identity: 158/845 - (18%)
• Similarity: 258/845 - (30%)
• Gaps: 337/845 - (39%)

  Fly     1 MEDELRCPTCKQLYANPVLLPCFHALCLGCALDIQTPYSPGSALPGAVNGAGAASAAGHNGLHGN 65
            :.:||.|..|.:|:..||..||.|..|:.| ||
Mouse     7 LAEELSCSVCLELFKEPVTTPCGHNFCMSC-LD-------------------------------- 38

  Fly    66 GGGAGGGAAAPVTNPNGPGTRHSSHSSAASTASSNTGSESVTSDQDQSDKVSIFSEADSGVVCCS 130
                                                                             
Mouse    39 ----------------------------------------------------------------- 38

  Fly   131 NTSRPVSYAGTGLLPGVGNVVAPPGAAYCLTCPLCRKLVFFDDGGVR-NLPTYRAMEAIVDRFCA 194
                     .|.::.|      ||     ..||.|||:.     .|| .|.....|.|:|::|..
Mouse    39 ---------ETWVVQG------PP-----YRCPQCRKVY-----QVRPQLQKNTVMCAVVEQFLQ 78

  Fly   195 REALR----------------------CQMCETDPKVASLICEQCEIRYC--------DACRELT 229
            .|..|                      |..|.|:  :|...|..|...:|        |:.....
Mouse    79 AEQARTPVDDWTPPARFSASSAATQVACDHCLTE--IAVKTCLVCMASFCQEHLRPHFDSPAFQD 141

  Fly   230 HPARGPLAKHTLVKPRGAAQQRESVCGEHEETLSQYCLSCKAPACGLCIGELRHQAHDVQSINVT 294
            ||.:.|:......|.....:.||..|.||.|     |:      |.:|:.|  |:         |
Mouse   142 HPLQSPIRDLLRRKCTQHNRLRELFCPEHGE-----CI------CHICLVE--HK---------T 184

  Fly   295 CKAQKTELSHNLQQLSEKARSTTEFIQRLKGMSDKVTESCMEFERLVHAQCEALIQAIHDRREYL 359
            |  ..|.||.....|..|.|:....:......:.|..|.....::.|....:..::.:  |:||:
Mouse   185 C--SPTTLSQASADLEYKLRNKLTIMHSHINGATKALEDVRSKQQCVQDSMKRKMEQL--RQEYM 245

  Fly   360 -LEAIRMDKDT-KIRILKDQQSNCTGK--------------LQQTTGLIQFCIEALKETDSAAFL 408
             ::|:....:| .:|.||:::....||              :|:....::..::   :.|...||
Mouse   246 EMKAVIDAAETSSLRKLKEEEKRVYGKFDTIYQVLVKKKSEMQKLKAEVELIMD---KGDEFEFL 307

  Fly   409 QVGSMLINRVTNTDMTWHQEVTNAAPRVSPIVDLTLD------------DAALARAIDNLNFIQM 461
            :..:.|....|.             |...|.:||..|            .:.|..:|..|   |.
Mouse   308 EKAAKLQGESTK-------------PVYIPKIDLDHDLIMGIYQGAADLKSELKHSIKKL---QK 356

  Fly   462 RAVK------DGDER----CPAAPMTPTILPSDCSAENNSVTVAWQPPNH-------SFVEGYVL 509
            ::.:      .||:.    .|..|...||.    ..:.....||..||:|       :|
Mouse   357 KSEEHNGSGNKGDQTQSTFKPVQPSKKTIQ----EKKTKKTPVAPGPPSHFSPNKLPTF------ 411

  Fly   510 ELDDGSGGEFREVYCGKETICTVDGLHFNSMYNARVKAFNSAGEGEYSELIGL------------ 562
                |:.|:..:   .|.|           ..:|..||  ||.:   .:.:|:
Mouse   412 ----GAPGQSLD---SKAT-----------SPDAAPKA--SAAQ---PDSVGVKAKVLENFLTKS 453

  Fly   563 QTAEVAWFT---FDPVLSGGAGSGLIFSKNNATVSV-EGWEH-----------RVALGSVGFSRG 612
            :|..:.:|.   ||   ...|.:.:..|....|.|| :|.:|           ...||...:..|
Mouse   454 RTELLEYFVKVIFD---YNTAHNKVSLSNKYTTASVSDGLQHYRSHPQRFTYCSQVLGLHCYKNG 515

  Fly   613 VHYWEFTI--DNYTADTDPAFGVARIDVAR---NKMLGKDEKSFAMYIDRQRSWFQ------HNS 666
            :||||..:  :|:.     ..|:....:.|   ...||::..|:.:      .||.      ||:
Mouse   516 IHYWEVELQKNNFC-----GVGICYGSMERQGPESRLGRNPNSWCV------EWFNNKISAWHNN 569

  Fly   667 IHERRVEGGITTGSTIGVLLDLER-HTLSFLVNEMPQGSVAFR-DLYGVFYPAVSI-NRGVTLTM 728
            : |:.:..  |..:.:||||:.:. ..:.|.|.|.......|: |.....|||..: :.|.||::
Mouse   570 V-EKTLPS--TKATRVGVLLNCDHGFVIFFAVTEKVHLMYKFKVDFTEALYPAFWVFSAGTTLSI 631

  Fly   729  728
            Mouse   632  631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trim9	NP_001188786.1	RING-HC_TRIM9-like_C-I	2..>35	CDD:438238	14/32 (44%)
		Bbox1_TRIM9-like_C-I	199..244	CDD:380861	12/74 (16%)
		Bbox2_TRIM9-like	255..291	CDD:380822	9/35 (26%)
		CC_brat-like	298..420	CDD:475168	24/137 (18%)
		FN3	472..564	CDD:238020	20/110 (18%)
		SPRY_PRY_TRIM67_9	561..735	CDD:293947	46/209 (22%)
Trim25	NP_033572.2	RING-HC_TRIM25_C-IV	6..75	CDD:438259	29/190 (15%)
		Bbox1_TRIM25-like_C-IV	105..151	CDD:380900	11/47 (23%)
		Bbox2_TRIM25_C-IV	154..190	CDD:380834	15/59 (25%)
		PTZ00121	<217..>389	CDD:173412	34/196 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	353..437		23/119 (19%)
		SPRY_PRY_TRIM25	464..632	CDD:293971	43/185 (23%)