Protein Alignment Trim9 and CMYA5

DIOPT Version :9

• Sequence 1: NP_001188786.1
• Gene: Trim9 / 34453
• FlyBaseID: FBgn0051721
• Length: 740
• Species: Drosophila melanogaster
• Sequence 2: NP_705838.3
• Gene: CMYA5 / 202333
• HGNCID: 14305
• Length: 4069
• Species: Homo sapiens
• Alignment Length: 594
• Identity: 125/594 - (21%)
• Similarity: 207/594 - (34%)
• Gaps: 159/594 - (26%)

  Fly   262 LSQYCLSCKAP--ACGLCIGELRHQAHDVQSINVTCKAQKTELSHNLQQLSEKARSTTEFIQRLK 324
            :..||.:||.|  |.....|  .|:.|:|.:::....|.|.:|:..|:.|.||:.....|:..::
Human  3509 IDTYCYTCKCPISATDKVFG--THKDHEVSTLDTAISAVKVQLAEFLENLQEKSLRIEAFVSEIE 3571

  Fly   325 GMSDKVTESCMEFERLVHAQCEALIQAI---HDRREYLLEAIRMDKDTKIRILKDQQSNCTGKLQ 386
            ...:.:.|:|.:.|:.:..|.|.:::.:   :|.:....|.:   |..|:..|.:|..:....:.
Human  3572 SFFNTIEENCSKNEKRLEEQNEEMMKKVLAQYDEKAQSFEEV---KKKKMEFLHEQMVHFLQSMD 3633

  Fly   387 QTTGLIQFCIEALKETDSAAFL----QVGSMLINRVTNT-----------------------DMT 424
            .....::..:...:|.|.|.||    ::...|::.:.:|                       |..
Human  3634 TAKDTLETIVREAEELDEAVFLTSFEEINERLLSAMESTASLEKMPAAFSLFEHYDDSSARSDQM 3698

  Fly   425 WHQEVTNAAPRVSPIVDLTLDDAALA--------RAIDNLNFIQMRAVKDGDE------------ 469
            ..|......||:.|....:.....:|        ..||:.....|...:|..|
Human  3699 LKQVAVPQPPRLEPQEPNSATSTTIAVYWSMNKEDVIDSFQVYCMEEPQDDQEVNELVEEYRLTV 3763

  Fly   470 -------------RC---------------PA-------APMTPTILPSDCSAENNSVTVAWQPP 499
                         ||               |:       ||.||.|...||:...|:.|:.|:|.
Human  3764 KESYCIFEDLEPDRCYQVWVMAVNFTGCSLPSERAIFRTAPSTPVIRAEDCTVCWNTATIRWRPT 3828

  Fly   500 NHSFVEGYVLELDDGSGGEFREVYC--------GKETICTVDGLHF------NSMYNARVKAFNS 550
            .....|.|.||            ||        |..:...:.||..      |..|...|:|.|:
Human  3829 TPEATETYTLE------------YCRQHSPEGEGLRSFSGIKGLQLKVNLQPNDNYFFYVRAINA 3881

  Fly   551 AGEGEYSELIGLQTAEVAWF----TFDPVLS-GGAGSGLIFSKNNATVSVEGWEHRVALGSVGFS 610
            .|..|.||...:.|....:.    |..|.|. ..:|:.:.|.:......:..     .||....|
Human  3882 FGTSEQSEAALISTRGTRFLLLRETAHPALHISSSGTVISFGERRRLTEIPS-----VLGEELPS 3941

  Fly   611 RGVHYWEFTIDNYTADTD-PAF--GVARIDVARNKMLGKDEKSFAMYIDRQRSWFQHNSIHERRV 672
            .|.||||.|:      || ||:  |:......:...||:.|          .||:.|.|..:|..
Human  3942 CGQHYWETTV------TDCPAYRLGICSSSAVQAGALGQGE----------TSWYMHCSEPQRYT 3990

  Fly   673 --EGGITTG-------STIGVLLDLERHTLSFLVNEMPQGSVAFRDLY--GVFYPAVSINRGVTL 726
              ..||.:.       :.:|:|||.....|.|:..|..|.....|..:  || :||.::.:....
Human  3991 FFYSGIVSDVHVTERPARVGILLDYNNQRLIFINAESEQLLFIIRHRFNEGV-HPAFALEKPGKC 4054

  Fly   727 TMHTAMDAP 735
            |:|..::.|
Human  4055 TLHLGIEPP 4063

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trim9	NP_001188786.1	RING-HC_TRIM9_like_C-I	2..37	CDD:319490
		zf-B_box	250..291	CDD:306989	10/30 (33%)
		ClassIIa_HDAC_Gln-rich-N	298..420	CDD:330228	24/128 (19%)
		FN3	472..564	CDD:238020	30/112 (27%)
		SPRY_PRY_TRIM67_9	561..735	CDD:293947	45/192 (23%)
CMYA5	NP_705838.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..177
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	341..387
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	442..525
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	538..558
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	597..705
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	732..793
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	844..872
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	890..948
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	979..1009
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1041..1097
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1160..1179
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1205..1237
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1540..1575
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1594..1742
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1757..1809
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1892..1988
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2064..2175
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2187..2259
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2385..2412
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2425..2463
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2494..2527
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2653..2706
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2750..2862
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3015..3037
		Required for RYR2 clustering. /evidence=ECO:0000250|UniProtKB:Q70KF4	3052..3365
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3119..3156
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3204..3231
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3386..3421
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3465..3495
		Amphipathic helix H1	3517..3544		7/28 (25%)
		B-box coiled-coil, BBC	3545..3672		24/129 (19%)
		iSH2_PI3K_IA_R	3546..3670	CDD:304922	24/126 (19%)
		Amphipathic helix H2	3631..3648		0/16 (0%)
		FN3	3719..3802	CDD:238020	9/82 (11%)
		Amphipathic helix H3	3751..3767		1/15 (7%)
		FN3	3804..3895	CDD:238020	28/102 (27%)
		SPRY_PRY_TRIM76	3897..4059	CDD:293955	44/183 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24099
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010