DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trim9 and Trim9

DIOPT Version :9

Sequence 1:	NP_001188786.1	Gene:	Trim9 / 34453	FlyBaseID:	FBgn0051721	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	XP_008762913.1	Gene:	Trim9 / 155812	RGDID:	621540	Length:	806	Species:	Rattus norvegicus

Alignment Length:	874	Identity:	331/874 - (37%)
Similarity:	454/874 - (51%)	Gaps:	212/874 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEDELRCPTCKQLYANPVLLPCFHALCLGCALDI--QTPYSPGSALPGAVNGAGAASAAGHNGLH 63
            ||:||:||.|...|..|::|||.|.||..||.:|  |||.|
  Rat     4 MEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQTPES------------------------ 44

  Fly    64 GNGGGAGGGAAAPVTNPNGPGTRHSSHSSAASTASSNTGSESVTSDQD--QSDKVSIFSEADSGV 126
                             ..|.:|.:|.|.              .||.|  ..||:|::||||||.
  Rat    45 -----------------ESPQSRRASGSG--------------VSDYDYLDLDKMSLYSEADSGY 78

  Fly   127 VCCSNTSRPVSYAGTGLLP---------GV--------------GNVVAPPGAAYCLTCPLCRKL 168
                     .||.|....|         ||              ...:||.....|:|||.|.:.
  Rat    79 ---------GSYGGFASAPTTPCQKSPNGVRVFPPAMPPPPTHLSPALAPVPRNSCITCPQCHRS 134

  Fly   169 VFFDDGGVRNLPTYRAMEAIVDRF--CAREALRCQMCETDPKVASLICEQCEIRYCDACRELTHP 231
            :..||.|:|..|..|.:|.::||:  ....||:||:||..||.|:::||||::.|||.||...||
  Rat   135 LILDDRGLRGFPKNRVLEGVIDRYQQSKAAALKCQLCEKAPKEATVMCEQCDVFYCDPCRLRCHP 199

  Fly   232 ARGPLAKHTLVKP------RGAAQQRESVCGEHE-ETLSQYCLSCKAPACGLCIGELRHQAHDVQ 289
            .|||||||.||.|      |..:.::.|.|.:|| |..|.||:.||.|.|..|:.|.:|.:|:|:
  Rat   200 PRGPLAKHRLVPPAQGRVSRRLSPRKVSTCTDHELENHSMYCVQCKMPVCYQCLEEGKHSSHEVK 264

  Fly   290 SINVTCKAQKTELSHNLQQLSEKARSTTEFIQRLKGMSDKVTESCMEFERLVHAQCEALIQAIHD 354
            ::....|..|::||..|..||::|:...||:.:|:.|..::.|:.:|||..:.|||:|||.|::.
  Rat   265 ALGAMWKLHKSQLSQALNGLSDRAKEAKEFLVQLRTMVQQIQENSVEFEACLVAQCDALIDALNR 329

  Fly   355 RREYLLEAIRMDKDTKIRILKDQQSNCTGKLQQTTGLIQFCIEALKETDSAAFLQVGSMLINRVT 419
            |:..||..:..:.:.|:::::||.|:||.||:|||||:::|:|.:||.|.:.|||:...||.||.
  Rat   330 RKAQLLARVNKEHEHKLKVVRDQISHCTVKLRQTTGLMEYCLEVIKENDPSGFLQISDALIRRVH 394

  Fly   420 NTDMTWHQEVTNAAPRVSPIVDLTLDDAALARAIDNLNFIQMRAVKDGDERCPAAPMTPTILPSD 484
            .|:..|.:  ....||::...||:||::.|.::|..|:|:|::|       ....|.||.:...:
  Rat   395 LTEDQWGK--GTLTPRMTTDFDLSLDNSPLLQSIHQLDFVQVKA-------SSPVPATPILQLEE 450

  Fly   485 CSAENNSVTVAWQPPNHSFV--EGYVLELDDGSGGEFREVYCGKETICTVDGLHFNSMYNARVKA 547
            |...|||.|::|:.|..|.|  :||:|||||||||:|||||.||||:||||||||||.|||||||
  Rat   451 CCTHNNSATLSWKQPPLSTVAADGYILELDDGSGGQFREVYVGKETMCTVDGLHFNSTYNARVKA 515

  Fly   548 FNSAGEGEYSELIGLQTAE---------------------------------------------- 566
            ||..|...||:.:.|||:|
  Rat   516 FNKTGVSPYSKTLVLQTSEAAGAHETKPMKDTDSEEQTLPFPVPSERLPLRRMSPFSSTLNLQPS 580

  Fly   567 --------------------------------------------------VAWFTFDPVLSGGAG 581
                                                              ||||.|||   |.|.
  Rat   581 FPGRSYFDFRSSPHQLSLHSSLQSLNAPGCNFETQSASYSQLVDIKKLLAVAWFAFDP---GSAH 642

  Fly   582 SGLIFSKNNATVSVEGWEHRVALGSVGFSRGVHYWEFTIDNYTADTDPAFGVARIDVARNKMLGK 646
            |.:|||.:|.||:...::.||.||..|||:||||||.|||.|....|||||||||||.::.||||
  Rat   643 SDIIFSNDNLTVTCSSYDDRVVLGKTGFSKGVHYWELTIDRYDNHPDPAFGVARIDVMKDMMLGK 707

  Fly   647 DEKSFAMYIDRQRSWFQHNSIHERRVEGGITTGSTIGVLLDLERHTLSFLVNEMPQGSVAFRDLY 711
            |:|::|||:|..||||.||:.|..|.|||||.|:||||||||.|.||:|.||...||.:||.::.
  Rat   708 DDKAWAMYVDNNRSWFMHNNSHTNRTEGGITKGATIGVLLDLNRKTLTFFVNNEQQGPIAFENVE 772

  Fly   712 GVFYPAVSINRGVTLTMHTAMDAPKMDYF 740
            |:|:||||:||.|.:|:||.:..|  |::
  Rat   773 GLFFPAVSLNRNVQVTLHTGLPVP--DFY 799

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trim9	NP_001188786.1	RING-HC_TRIM9_like_C-I	2..37	CDD:319490	18/36 (50%)
		zf-B_box	250..291	CDD:306989	17/41 (41%)
		ClassIIa_HDAC_Gln-rich-N	298..420	CDD:330228	50/121 (41%)
		FN3	472..564	CDD:238020	55/93 (59%)
		SPRY_PRY_TRIM67_9	561..735	CDD:293947	102/269 (38%)
Trim9	XP_008762913.1	RING-HC_TRIM9	5..52	CDD:319669	21/48 (44%)
		Bbox1_TRIM9_C-I	166..212	CDD:380901	18/47 (38%)
		Bbox2_TRIM9_C-I	223..271	CDD:380884	26/54 (48%)
		BBC	273..399	CDD:128778	47/125 (38%)
		FN3	453..532	CDD:238020	36/80 (45%)
		SPRY_PRY_TRIM67_9	631..796	CDD:293947	67/113 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	160	1.000	Domainoid score	I3965
eggNOG	1	0.900	-	-		E1_KOG4367
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9045
Inparanoid	1	1.050	611	1.000	Inparanoid score	I882
OMA	1	1.010	-	-		QHG48085
OrthoDB	1	1.010	-	-		D239986at33208
OrthoFinder	1	1.000	-	-		FOG0003096
OrthoInspector	1	1.000	-	-		otm46078
orthoMCL	1	0.900	-	-		OOG6_105047
Panther	1	1.100	-	-	O	PTHR24099
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2070
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.880