DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trim9 and FSD2

DIOPT Version :9

Sequence 1:	NP_001188786.1	Gene:	Trim9 / 34453	FlyBaseID:	FBgn0051721	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_001007123.1	Gene:	FSD2 / 123722	HGNCID:	18024	Length:	749	Species:	Homo sapiens

Alignment Length:	600	Identity:	133/600 - (22%)
Similarity:	221/600 - (36%)	Gaps:	146/600 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   257 EHEETLSQYCLSCKAPACGLCIGELRHQAHDVQSINVTCKAQKTELSHNLQQLSEKARSTTEFIQ 321
            :.||....:|::||.|..........|:.|:|..:|...::.|.|:..|:.:|.::......|..
Human   171 DEEEAADVFCVTCKTPIRAFQKVFDEHKEHEVIPLNEALESAKDEIHKNMYKLEKQIIEMENFAN 235

  Fly   322 RLKGMSDKVTESCMEFERLVHAQCEALIQAIHDRREYLLEAIRMDKDTKIRILKDQQSNCTGKLQ 386
            .|:.:...|.|:..:.|:...:....:::.:..:.|..::|:...|..|:..|..|..:|...|.
Human   236 HLEEVFITVEENFGKQEQNFESHYNEILETLAQKYEEKIQALGEKKKEKLEALYGQLVSCGENLD 300

  Fly   387 QTTGLIQFCIEALKETDSAAFLQVGSMLINRV-----TNTDMTWHQEVTNAAPRVSPIVDLTLDD 446
            ....|:: .||.:...:...|::....:.:|:     |.||:    |: :|.|...   |.|||.
Human   301 TCKELME-TIEEMCHEEKVDFIKDAVAMADRLGKFLKTKTDV----EI-SAQPEFE---DQTLDF 356

  Fly   447 AALARAIDNLNFIQMRAVKDGDERCPAAPMTPTILPSDCSAENNSVTVAWQPPNHSFVEGYVLE- 510
            :.:.:.:.::|.|.          .|:||:....:|:  ||..:||.|.|...:...||.|.|.
Human   357 SDVEQLMGSINTIP----------APSAPVINPQVPN--SATGSSVRVCWSLYSDDTVESYQLSY 409

  Fly   511 --LDDGSGG----EFREVYCGKETICTVDGLHFNSMYNARVKAFNSAGEGEYSE----------- 558
              :.|.|.|    ||....  |||.|:|..|..|:.|...|.|.|.||....||
Human   410 RPVQDSSPGTDQAEFTVTV--KETYCSVTNLVPNTQYEFWVTAHNRAGPSPSSERAVYMTAPSPP 472

  Fly   559 -----------------------------------------------LIGLQTAEV--------A 568
                                                           ::|:.|.|.        :
Human   473 IIKTKEIRSCEEAVLICWESGNLNPVDSYTVELTQAESPEASGVTESVVGIPTCESVVQLQPGRS 537

  Fly   569 WFTFDPVLSGGAGS-----------GLIFSKNN------ATVSVEGW-----EHR---------- 601
            :..:...|:.|..|           |..|..|.      .|:|.:|.     |.|
Human   538 YIIYVRALNMGGPSVRSEPATVHTIGSYFRLNKDTCHPWLTISEDGLTAVRSERRTPARELSPSD 602

  Fly   602 -------VALGSVGFSRGVHYWEFTIDNYTADTDPAFGVARIDVARNKMLGKDEKSFAMYIDRQR 659
                   ..:|::...||.||||..:|.:   .|...|||..||.:.:.||.:..|:.|......
Human   603 THFTRCVAVMGNLIPVRGHHYWEVEVDEH---LDYRVGVAFADVRKQEDLGANCLSWCMRHTFAS 664

  Fly   660 SWFQHNSIHERRV-EGGITT-GSTIGVLLDLERHTLSFLVNEMPQGSVAFR-DLYGVFYPAVSIN 721
            |..::..:|.|.. :..||. ...||:|||.|...|||...::.|....|. .|:...:|..|:.
Human   665 SRHKYEFLHNRTTPDIRITVPPKKIGILLDYEHSKLSFFNVDLSQHLYTFSCQLHEFVHPCFSLE 729

  Fly   722 RGVTLTMHTAMDAPK 736
            :...|.:|..:..||
Human   730 KPGCLKVHNGISMPK 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trim9	NP_001188786.1	RING-HC_TRIM9_like_C-I	2..37	CDD:319490
		zf-B_box	250..291	CDD:306989	9/33 (27%)
		ClassIIa_HDAC_Gln-rich-N	298..420	CDD:330228	22/126 (17%)
		FN3	472..564	CDD:238020	35/156 (22%)
		SPRY_PRY_TRIM67_9	561..735	CDD:293947	53/223 (24%)
FSD2	NP_001007123.1	DUF3552	188..>333	CDD:330423	26/145 (18%)
		FN3	372..457	CDD:214495	32/88 (36%)
		FN3	469..561	CDD:238020	6/91 (7%)
		SPRY_PRY_TRIM76_like	565..740	CDD:293956	46/177 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24099
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010