DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trim9 and MID2

DIOPT Version :9

Sequence 1:	NP_001188786.1	Gene:	Trim9 / 34453	FlyBaseID:	FBgn0051721	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_036348.2	Gene:	MID2 / 11043	HGNCID:	7096	Length:	735	Species:	Homo sapiens

Alignment Length:	786	Identity:	188/786 - (23%)
Similarity:	289/786 - (36%)	Gaps:	233/786 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEDELRCPTCKQLYANPVLLPCFHALCLGCALDIQTPYSPGSALPGAVNGAGAASAAGHNGLHGN 65
            :|.||.||.|.:|:.:|:||||.|:||..||
Human    24 LESELTCPICLELFEDPLLLPCAHSLCFSCA---------------------------------- 54

  Fly    66 GGGAGGGAAAPVTNPNGPGTRHSSHSSAASTASSNTGSESVTSDQDQSDKVSIFSEADSGVVCCS 130
                                    |....|:.||....|.:|:.|
Human    55 ------------------------HRILVSSCSSGESIEPITAFQ-------------------- 75

  Fly   131 NTSRPVSYAGTGLLPGVGNVVAPPGAAYCLTCPLCRKLVFFDDGGVRNLPTYRAMEAIVDRF--- 192
                                           ||.||.::..:..|:..|.....::.|:|||
Human    76 -------------------------------CPTCRYVISLNHRGLDGLKRNVTLQNIIDRFQKA 109

  Fly   193 ----------------------CAREALRCQMCETD-PKVASLICEQCEIRYCDACRELTHPARG 234
                                  .:.|.:.||.||.| |:.|...|..||:.|||.|...|||.:.
Human   110 SVSGPNSPSESRRERTYRPTTAMSSERIACQFCEQDPPRDAVKTCITCEVSYCDRCLRATHPNKK 174

  Fly   235 PLAKHTLVKPRGAAQQRESVCGEHE-ETLSQYCLSCKAPACGLC--IGELRHQAHDVQSINVTCK 296
            |...|.||:|......|...|.:|| |.::.||:|.....|.||  :|  ||:.|.|.|:|...:
Human   175 PFTSHRLVEPVPDTHLRGITCLDHENEKVNMYCVSDDQLICALCKLVG--RHRDHQVASLNDRFE 237

  Fly   297 AQKTELSHNLQQLSEKARSTTEFIQRLKGMSDKVTESCMEFERLVHAQCEALIQAIHDRREYLLE 361
            ..|..|..||..|.::.......:.:|..:..:|..:....|..:..:|:.|::.|..|::.:..
Human   238 KLKQTLEMNLTNLVKRNSELENQMAKLIQICQQVEVNTAMHEAKLMEECDELVEIIQQRKQMIAV 302

  Fly   362 AIRMDKDTKIRILKDQQSNCTGKLQQTTGLIQFCIEALKETDSAAFLQVGSMLINRVTNTDMTWH 426
            .|:..|..|:|.|..|.:||...|:::|.||......|||.|.|.|||....:..||.
Human   303 KIKETKVMKLRKLAQQVANCRQCLERSTVLINQAEHILKENDQARFLQSAKNIAERVA------- 360

  Fly   427 QEVTNAAPRVSPIVDLTLDDAALARAIDNLNFIQMRAVKDGDERCPAAPMTPTILPSDCSAENNS 491
              :..|:.:|. |.|:..:||....|:|   |.:.:.:.:|.:.. .||..|:|....|:|.:::
Human   361 --MATASSQVL-IPDINFNDAFENFALD---FSREKKLLEGLDYL-TAPNPPSIREELCTASHDT 418

  Fly   492 VTVAWQPPNHSFVEGYVLELDDGSG------------GEFREVYCGKETI-C------------- 530
            :||.|...:...:..|.|:....:|            |.:.|:...||.: |
Human   419 ITVHWISDDEFSISSYELQYTIFTGQANFISKSWCSWGLWPEIRKCKEAVSCSRLAGAPRGLYNS 483

  Fly   531 ---------------TVDGLHFNSMYNARVKAFNSAGEGEYSELIGLQTAEVAWFTFDPVLSGG- 579
                           ||.||...:.|...|||.|.|| ...||...|:|.... |..||.::..
Human   484 VDSWMIVPNIKQNHYTVHGLQSGTRYIFIVKAINQAG-SRNSEPTRLKTNSQP-FKLDPKMTHKK 546

  Fly   580 ---AGSGLIFSKNNATVSVEGWEHRV-------ALGSVGFSRGVHYWEFTIDNYTADTDPAFGVA 634
               :..||...|:.:::.......|.       |.|::....|.||||..:.   :.|..|.|:|
Human   547 LKISNDGLQMEKDESSLKKSHTPERFSGTGCYGAAGNIFIDSGCHYWEVVMG---SSTWYAIGIA 608

  Fly   635 RIDVARNKMLGKDEKSFAMYIDRQRSWF--QHNS--------IHERRVEGGITTGSTIGVLLDLE 689
            .....:|:.:||:..|:.  ..|..|.|  :||:        .|.:|          :|||||.:
Human   609 YKSAPKNEWIGKNASSWV--FSRCNSNFVVRHNNKEMLVDVPPHLKR----------LGVLLDYD 661

  Fly   690 RHTLSF 695
            .:.|||
Human   662 NNMLSF 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trim9	NP_001188786.1	RING-HC_TRIM9_like_C-I	2..37	CDD:319490	17/34 (50%)
		zf-B_box	250..291	CDD:306989	16/43 (37%)
		ClassIIa_HDAC_Gln-rich-N	298..420	CDD:330228	34/121 (28%)
		FN3	472..564	CDD:238020	31/132 (23%)
		SPRY_PRY_TRIM67_9	561..735	CDD:293947	39/156 (25%)
MID2	NP_036348.2	RING-HC_MID2	30..82	CDD:319668	25/160 (16%)
		Bbox1_MID2_C-I	135..187	CDD:380895	23/51 (45%)
		Bbox2_MID2_C-I	193..232	CDD:380881	15/40 (38%)
		BBC	239..364	CDD:128778	34/133 (26%)
		COS	343..394	CDD:408352	16/63 (25%)
		FN3	401..531	CDD:238020	31/130 (24%)
		SPRY_PRY_TRIM1	536..705	CDD:293974	37/147 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24099
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010