DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trim9 and mid1

DIOPT Version :9

Sequence 1:	NP_001188786.1	Gene:	Trim9 / 34453	FlyBaseID:	FBgn0051721	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	XP_002663478.1	Gene:	mid1 / 100330952	ZFINID:	ZDB-GENE-110411-205	Length:	667	Species:	Danio rerio

Alignment Length:	813	Identity:	201/813 - (24%)
Similarity:	304/813 - (37%)	Gaps:	229/813 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEDELRCPTCKQLYANPVLLPCFHALCLGCALDIQTPYSPGSALPGAVNGAGAASAAGHNGLHGN 65
            :|.||.||.|.:|:.:|:||||.|:||..||..|.|
Zfish     4 LESELTCPICLELFEDPLLLPCAHSLCFHCAHRILT----------------------------- 39

  Fly    66 GGGAGGGAAAPVTNPNGPGTRHSSHSSAASTASSNTGSESVTSDQDQSDKVSIFSEADSGVVCCS 130
                                   ||.:|.                |:|.|
Zfish    40 -----------------------SHCAAF----------------DESSK--------------- 50

  Fly   131 NTSRPVSYAGTGLLPGVGNVVAPPGAAYCLTCPLCRKLVFFDDGGVRNLPTYRAMEAIVDRF--- 192
                                  ||.|   ..||.||.::..|..|:..|.....::.|::||
Zfish    51 ----------------------PPSA---FQCPTCRYVITLDQQGLDGLKRNVTLQNIIERFQKA 90

  Fly   193 ---------------------CAREALRCQMCETD-PKVASLICEQCEIRYCDACRELTHPARGP 235
                                 .|.||::||.||.| |:.|...|..||:.||..|...|||.:.|
Zfish    91 SLSGPNSPTETRKQISPSAMSSACEAVQCQFCEQDPPQEAVKTCVTCEVSYCQECLRATHPNKKP 155

  Fly   236 LAKHTLVKPRGAAQQRESVCGEH-EETLSQYCLSCKAPACGLC--IGELRHQAHDVQSINVTCKA 297
            ...|.|.:|...|:.|...|.|| ||.::.||::.:...|.||  :|  .|:.|.|.|:......
Zfish   156 FTGHRLTEPVPDARLRGLACPEHGEEKVNMYCITDEQLICSLCKLVG--HHREHQVASLGERYDK 218

  Fly   298 QKTELSHNLQQLSEKARSTTEFIQRLKGMSDKVTESCMEFE-RLVH------AQCEALIQAIHDR 355
            .|..|..||..|.::.       ..|:.:..|:.::|...| ...|      .:|:.||..:..|
Zfish   219 LKQMLDSNLSNLIKRN-------SELENLMAKLIQTCQHVEHNAAHQESKLTEECDTLINIVQQR 276

  Fly   356 REYLLEAIRMDKDTKIRILKDQQSNCTGKLQQTTGLIQFCIEALKETDSAAFLQVGSMLINRVTN 420
            |:.:...|:..|..::|.|..|.:||...:::::.||....:||||||.|.|||:...:..||:
Zfish   277 RQIIGTKIKEGKVVRLRKLAQQIANCKQFVERSSSLIIQADQALKETDHARFLQMAKSISERVS- 340

  Fly   421 TDMTWHQEVTNAAPRVSPIVDLTLDDAALARAIDNLNFIQMRAVKDGDERCPAAPMTPTILPSDC 485
                    :..|:.:|. |.::.|:|...|.|:|   |.:.:.:.:|.:.. .||..|||....|
Zfish   341 --------MATASSQVL-IPEINLNDTFDAFALD---FSREKKMLEGLDYL-TAPNAPTIREELC 392

  Fly   486 SAENNSVTVAWQPPNHSFVEGYVLELDDGSGGEFREVYCG-----------KETICTVDGLHFNS 539
            :|.::::||.|...:...|..|.|:....:|.......|.           |:...||.||...:
Zfish   393 TASHDTITVHWTSEDEFSVVSYELQYTISTGQANVVSLCNSMDSWMIVPNIKQNHYTVHGLQSGT 457

  Fly   540 MYNARVKAFNSAGEGEYSELIGLQTAEVAWFTFDPVLSGGAGSGLIFSKNNATVSVE-------- 596
            .|...|||.|.|  |..|...|........|..||   ..|...|..|.:|.||..:
Zfish   458 KYIFIVKAMNQA--GSRSSPPGQLKTNSQPFKLDP---KSAHRKLKVSHDNLTVERDEASSMKSH 517

  Fly   597 ------GWEHRVALGSVGFSRGVHYWEFTIDNYTADTDPAFGVARIDVARNKMLGKDEKSFAMYI 655
                  |..:....|:|....|.||||..|.   ..|..|.|:|.....::..:|||..|:.  :
Zfish   518 AQDRFGGTGNYGVTGNVYIDSGRHYWEVLIG---GSTWFAIGIAYKSAPKHGWVGKDSTSWV--L 577

  Fly   656 DR-QRSW-FQHN--------SIHERRVEGGITTGSTIGVLLDLERHTLSFL----VNEMPQGSVA 706
            .| ..|| .:||        |.|.||          :|||||.:..:|:|.    ...:....:|
Zfish   578 SRCNTSWAVRHNSKEFPIEPSPHMRR----------LGVLLDYDSGSLAFYDAAGTQHLYTFDIA 632

  Fly   707 FRD----LYGVFYPAVSINRGVTLTMHTAMDAP 735
            |..    ::.|:...:::..|:.:..|..:..|
Zfish   633 FSQPICPVFSVWNKCLTVLTGLPIPDHLEISDP 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trim9	NP_001188786.1	RING-HC_TRIM9_like_C-I	2..37	CDD:319490	18/34 (53%)
		zf-B_box	250..291	CDD:306989	15/43 (35%)
		ClassIIa_HDAC_Gln-rich-N	298..420	CDD:330228	36/128 (28%)
		FN3	472..564	CDD:238020	29/102 (28%)
		SPRY_PRY_TRIM67_9	561..735	CDD:293947	48/205 (23%)
mid1	XP_002663478.1	RING	9..64	CDD:238093	29/162 (18%)
		BBOX	115..160	CDD:197662	19/44 (43%)
		BBOX	175..212	CDD:237988	14/38 (37%)
		iSH2_PI3K_IA_R	219..344	CDD:304922	36/140 (26%)
		FN3	381..481	CDD:238020	29/101 (29%)
		SPRY	485..661	CDD:295394	47/193 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24099
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010