DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trim9 and trim46b

DIOPT Version :9

Sequence 1:	NP_001188786.1	Gene:	Trim9 / 34453	FlyBaseID:	FBgn0051721	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	XP_009292294.1	Gene:	trim46b / 100034631	ZFINID:	ZDB-GENE-060503-466	Length:	780	Species:	Danio rerio

Alignment Length:	832	Identity:	195/832 - (23%)
Similarity:	294/832 - (35%)	Gaps:	245/832 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEDELRCPTCKQLYANPVLLPCFHALCLGCALD--IQTPYSPGSALPGAVNGAGAASAAGHNGLH 63
            ||.||:||.||.:...|::|||.|::||.||.:  ||:.| |...||...|
Zfish    20 MEQELQCPVCKDIVKQPIVLPCLHSVCLMCASEVLIQSGY-PQPELPPEPN-------------- 69

  Fly    64 GNGGGAGGGAAAPVTNPNGPGTRHSSHSSAASTASSNTGSESVTSDQDQSDKVSIFSEADSGVVC 128
                       :|.:.||....|                  .:.....:||:|.
Zfish    70 -----------SPASTPNMRSPR------------------QMRRPMPKSDRVD----------- 94

  Fly   129 CSNTSRPVSYAGTGLLPGVGNVVAPPGAAYCLTCPLCRKLVFFDDGG----VRNLPTYRAMEAIV 189
                  .:..:|:|..||......|| ......|..|.:.|...:.|    :|||    |:|.||
Zfish    95 ------RLLRSGSGTYPGRRRKDGPP-PLMLFPCAPCGRDVELGERGLAECMRNL----ALERIV 148

  Fly   190 DRF-----CAREALRCQMCETDPKV-ASLICEQCEIRYCDACRELTHPARGPLAKHTLVKPRGAA 248
            :|:     ....|:.||.|:....: |:..|..|...:|:.|.:|.||...|.|:|..|:|....
Zfish   149 ERYRHTVSLGSVAVMCQFCKPPQALEATKGCADCRASFCNECFKLYHPWGTPRAQHEHVQPTLNF 213

  Fly   249 QQRESVCGEH-EETLSQYCLSCKAPACGLCIGELR--HQAHDVQSINVTCKAQKTELSHNLQQ-L 309
            :.:...|.|| :|.|..||.||:...|.||  :||  |..|.:..:....:..|.:::..|.. |
Zfish   214 RPKVLTCPEHDQERLQYYCKSCQMLLCSLC--KLRRVHAGHKIAPVTQAYQTLKDKITKELNYIL 276

  Fly   310 SEKARSTTEFIQRLKGMSDKVTESCMEFERLVHAQCEALIQAIHDRREYLLEAIRMDKDTKIRIL 374
            |.:....|:..|....::.....|....|:|.|...| ::..:.:|:..|.:|:...:..:...|
Zfish   277 SNQDMVLTQITQLESAVTQTEVNSVSAKEQLSHCVKE-IMALLTERQTMLAQALEGSRQRRADAL 340

  Fly   375 KDQQSNCTGKLQQTTGLIQFCIEALKETDSAAFLQVGSMLINRVTNTDMTWHQEVTNAAPRVSPI 439
            ..|.:.....|:. .||:.|..|.|||.|.::|:....:..||:..:..:......:|.|...
Zfish   341 SSQVAEKRSLLEH-AGLMAFTQELLKENDPSSFVHAARITHNRLAQSIESMQHFALSADPSFR-- 402

  Fly   440 VDLTLDDAALARAIDNLNFIQMRAVKDGDERCPAAPMTPTI----------------LPSDCSAE 488
             ...||.:...:.:.:|||||             ||..|.|                ||.|.
Zfish   403 -HFQLDISRELKLLTDLNFIQ-------------APFAPVIDTQRTLAYDQLFLCWRLPQDS--- 450

  Fly   489 NNSVTVAWQPPNHSFVE----GYVLELDDGSGGEFR-------------EVYCGKETICTVDGLH 536
                |.||    |..||    |.|  ...|:.|..|             |...|  |...:|.|.
Zfish   451 ----TPAW----HFSVEFRRRGVV--PGGGARGGIRGGLAAARWGWQRLEEVTG--TCAVIDRLE 503

  Fly   537 FNSMYNARVKAFNSAGEGEYSELIGLQTAEVAWFTFDPVLS-------GGAGSGLIFSKNNATV- 593
            .:|:|..||:..|.||.|||||.:.|.|...      |||:       |.....|:.||.....
Zfish   504 MDSVYVLRVRGCNKAGFGEYSEEVYLHTPPA------PVLNFYLDSRWGLHADRLVVSKEQRCAR 562

  Fly   594 SVEGWE------------HRVA---LGSVGFSRGVHYWEFTIDNYTADTDPAFGVARIDVARNKM 643
            ||.|..            |..|   :|.|..::|.|||..::       :|...:.::.|.....
Zfish   563 SVPGLSLLQAADRALTSCHLTADLLVGDVAITQGRHYWACSV-------EPGSYLVKVGVGLESK 620

  Fly   644 L-----------------------GKDEKS-----FAMYIDRQRSWFQHNSIHERRV-----EGG 675
            |                       |.::.|     ||.........:..:|::....     |.|
Zfish   621 LQEWFHLPQDMASPRFDPDSGHDSGAEDSSDSPPPFAFLTMGMGKIYLPSSVNSHHCNANYRESG 685

  Fly   676 ITTGS--------------TIGVLLDLERHTLSFLVNEMPQGSVAFRDLYGV 713
            .|.|:              .:||.||.|:            |.|.|.|.:.:
Zfish   686 FTNGNGPSSPTGVTYPLPPRLGVCLDFEK------------GRVTFYDAHSL 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trim9	NP_001188786.1	RING-HC_TRIM9_like_C-I	2..37	CDD:319490	18/36 (50%)
		zf-B_box	250..291	CDD:306989	16/43 (37%)
		ClassIIa_HDAC_Gln-rich-N	298..420	CDD:330228	28/122 (23%)
		FN3	472..564	CDD:238020	36/124 (29%)
		SPRY_PRY_TRIM67_9	561..735	CDD:293947	41/223 (18%)
trim46b	XP_009292294.1	zf-C3HC4_2	26..58	CDD:290634	15/31 (48%)
		zf-B_box	215..257	CDD:279037	16/43 (37%)
		iSH2_PI3K_IA_R	259..378	CDD:304922	26/120 (22%)
		FN3	438..531	CDD:238020	32/107 (30%)
		SPRY_PRY_TRIM46	538..756	CDD:293952	36/207 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24099
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010