DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18302 and LIPK

DIOPT Version :9

Sequence 1:	NP_609420.1	Gene:	CG18302 / 34452	FlyBaseID:	FBgn0032266	Length:	406	Species:	Drosophila melanogaster
Sequence 2:	XP_011538375.1	Gene:	LIPK / 643414	HGNCID:	23444	Length:	419	Species:	Homo sapiens

Alignment Length:	408	Identity:	131/408 - (32%)
Similarity:	210/408 - (51%)	Gaps:	38/408 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 CYGILISLFIFCDTASGDLIKVDK---TILEDANLITPDLIKKYGYPAETHKIQAKDGFVLTAHR 71
            |:.:|:          |.:...||   ....:||:....:|..:|||.|.:.:..|||::|..:|
Human    29 CWMLLL----------GSMYGYDKKGNNANPEANMNISQIISYWGYPYEEYDVTTKDGYILGIYR 83

  Fly    72 IPKPGGQP--------VLLVHGLLDSSVAYVILGPERSLGFLLSDMGYDVWLLNTRGNRYSRKHK 128
            ||...|.|        |.|.|||:.|:..::...|..||.|||:|.||||||.|:|||.:||||.
Human    84 IPHGRGCPGRTAPKPAVYLQHGLIASASNWICNLPNNSLAFLLADSGYDVWLGNSRGNTWSRKHL 148

  Fly   129 RYHRYQPQFWDFSFHELGVYDLPAAIDYVLARSKDFEQIHYVGHSQGTTSFFVMGSERSAYMKKI 193
            :.....|::|.||..|:..|||||.|::::.::.. ::::|||||||||..|:..|......|||
Human   149 KLSPKSPEYWAFSLDEMAKYDLPATINFIIEKTGQ-KRLYYVGHSQGTTIAFIAFSTNPELAKKI 212

  Fly   194 KLMQALAPVVFWDYIDSPIILTFVKYLRPLVFIARS-----FGIYEFPPENEVWRSLIHKICS-F 252
            |:..||||||...|..||        ::.|..::|.     ||...|.|.....:.:..|:|: .
Human   213 KIFFALAPVVTVKYTQSP--------MKKLTTLSRRVVKVLFGDKMFHPHTLFDQFIATKVCNRK 269

  Fly   253 VFQNTCTYFLMEAMGVDYAQFNSSLLPLFTGHASSGSSVKSLEHYGQQIHSGGFFKYNYYSTWEN 317
            :|:..|:.||....|.|....|.|.|.::..|..:|:||:::.|:.|.::||....:::.::.:|
Human   270 LFRRICSNFLFTLSGFDPQNLNMSRLDVYLSHNPAGTSVQNMLHWAQAVNSGQLQAFDWGNSDQN 334

  Fly   318 RRNHGVDTPPQYKLTNVDCKVALYYSRNDRLTSDKDVVRLRDILPNVVLDYMFPDPLYNHINFIW 382
            ..:....|||.|.:|.::...|::....|.:...|||..|...:.|::...:.|.  |||::|..
Human   335 MMHFHQLTPPLYNITKMEVPTAIWNGGQDIVADPKDVENLLPQIANLIYYKLIPH--YNHVDFYL 397

  Fly   383 GNDVKTVLNDRMIELMRK 400
            |.|....:...:|.||.:
Human   398 GEDAPQEIYQDLIILMEE 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18302	NP_609420.1	PLN02872	13..399	CDD:215470	129/402 (32%)
		Abhydro_lipase	43..97	CDD:282003	20/61 (33%)
		Abhydrolase_5	79..>208	CDD:289465	60/136 (44%)
LIPK	XP_011538375.1	PLN02872	31..410	CDD:215470	127/399 (32%)
		Abhydro_lipase	55..117	CDD:282003	20/61 (33%)
		Abhydrolase_5	99..>246	CDD:289465	64/155 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141843
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	271	1.000	Inparanoid score	I3005
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100408
Panther	1	1.100	-	-	O	PTHR11005
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.810