DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18302 and Lipa

DIOPT Version :9

Sequence 1:	NP_609420.1	Gene:	CG18302 / 34452	FlyBaseID:	FBgn0032266	Length:	406	Species:	Drosophila melanogaster
Sequence 2:	NP_001104570.1	Gene:	Lipa / 16889	MGIID:	96789	Length:	397	Species:	Mus musculus

Alignment Length:	410	Identity:	142/410 - (34%)
Similarity:	219/410 - (53%)	Gaps:	42/410 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 YCYGILISLFIFCDTASGDLIKVDKTILEDANLITPDLIKKYGYPAETHKIQAKDGFVLTAHRIP 73
            :..|||:|     ...:|.:..||    .:.|:...::|.::|||.|.|.:...||::|:.||||
Mouse    10 FTIGILLS-----RVPTGTVSAVD----PEVNMNVTEIIMRWGYPGEEHSVLTGDGYILSIHRIP 65

  Fly    74 K-------PGGQPVL-LVHGLLDSSVAYVILGPERSLGFLLSDMGYDVWLLNTRGNRYSRKHKRY 130
            :       .|.:||: |.||||..|..:|......||||||:|.|:|||:.|:|||.:|.|||..
Mouse    66 RGRKNHFGKGPRPVVYLQHGLLADSSNWVTNIDNSSLGFLLADAGFDVWMGNSRGNTWSLKHKTL 130

  Fly   131 HRYQPQFWDFSFHELGVYDLPAAIDYVLARSKDFEQIHYVGHSQGTTSFFVMGSERSAYMKKIKL 195
            ...|.:||.|||.|:..|||||:|:|:|.::.. |||:|||||||.|..|:..|:.....||||:
Mouse   131 SVSQDEFWAFSFDEMAKYDLPASINYILNKTGQ-EQIYYVGHSQGCTIGFIAFSQMPELAKKIKM 194

  Fly   196 MQALAPVVFWDYIDSPIILTFVKYLRPLVFIARSFGIYEFPPENEV--WRSLIHKICSFVFQNTC 258
            ...||||:..::...| :|...:...||  :...||..:|.|::.:  |.| ||.....:.:..|
Mouse   195 FLVLAPVLSLNFASGP-LLQLGRLPDPL--LKDMFGQKQFLPQSAMLKWLS-IHVCTHVIMKELC 255

  Fly   259 --TYFLMEAMGVDYAQFNSSLLPLFTGHASSGSSVKSLEHYGQQIHSGGFFKY------NYYSTW 315
              .:||:  .|.:....|.|.:.::|.|..:|:||:::.|:||      .|||      ::.|:.
Mouse   256 ANVFFLL--CGFNEKNLNMSRVDVYTTHCPAGTSVQNMLHWGQ------VFKYRKLQAFDWGSSE 312

  Fly   316 ENRRNHGVDTPPQYKLTNVDCKVALYYSRNDRLTSDKDVVRLRDILPNVVLDYMFPDPLYNHINF 380
            :|..::....||.|.:.|:....||:....|.|....|:..|...:|.:|.....|:  ::|::|
Mouse   313 KNYFHYNQSFPPSYNIKNMRLPTALWSGGRDWLADINDITILLTQIPKLVYHKNIPE--WDHLDF 375

  Fly   381 IWGNDVKTVLNDRMIELMRK 400
            |||.|....|.|.:|.||:|
Mouse   376 IWGLDAPWKLYDEIISLMKK 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18302	NP_609420.1	PLN02872	13..399	CDD:215470	139/403 (34%)
		Abhydro_lipase	43..97	CDD:282003	23/61 (38%)
		Abhydrolase_5	79..>208	CDD:289465	64/129 (50%)
Lipa	NP_001104570.1	PLN02872	6..394	CDD:215470	140/407 (34%)
		Abhydro_lipase	35..96	CDD:282003	23/60 (38%)
		Abhydrolase_5	78..>192	CDD:289465	57/114 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831895
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	278	1.000	Inparanoid score	I2905
Isobase	1	0.950	-	0.977872	Normalized mean entropy	S1866
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100408
Panther	1	1.100	-	-	O	PTHR11005
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.760