DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18302 and LIPJ

DIOPT Version :9

Sequence 1:	NP_609420.1	Gene:	CG18302 / 34452	FlyBaseID:	FBgn0032266	Length:	406	Species:	Drosophila melanogaster
Sequence 2:	NP_001010939.2	Gene:	LIPJ / 142910	HGNCID:	21773	Length:	366	Species:	Homo sapiens

Alignment Length:	371	Identity:	127/371 - (34%)
Similarity:	206/371 - (55%)	Gaps:	24/371 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 LIKKYGYPAETHKIQAKDGFVLTAHRIP-------KPGGQPVL--LVHGLLDSSVAYVILGPERS 101
            :|..:|||.|.:.|..:||::|..:|||       |...|.|:  |.||||.|:.:::...|..|
Human     6 IISYWGYPDEEYDIVTEDGYILGLYRIPYWRTDNNKNLAQRVVVYLQHGLLTSASSWISNLPNNS 70

  Fly   102 LGFLLSDMGYDVWLLNTRGNRYSRKHKRYHRYQPQFWDFSFHELGVYDLPAAIDYVLARSKDFEQ 166
            |||:|:|.|||||:.|:|||.:||||........:||.|||.|:..|||||:||:.:.:::. |:
Human    71 LGFILADAGYDVWMGNSRGNTWSRKHLYLETSSKEFWAFSFDEMAKYDLPASIDFTVKQTRQ-EE 134

  Fly   167 IHYVGHSQGTTSFFVMGSERSAYMKKIKLMQALAPVVFWDYIDSPIILTFVKYLRPLVFIARSF- 230
            |.|||||||||..|:..|..|...::||:..|||||....|:.||:|....|:..    |..:|
Human   135 IFYVGHSQGTTIGFITFSTISKIAERIKIFFALAPVFSTKYLKSPLIRMTYKWKS----IVMAFS 195

  Fly   231 GIYEFPPENEVWRSLIHKICSF-VFQNTCTYFLMEAMGVDYAQFNSSLLPLFTGHASSGSSVKSL 294
            |..:|.|:....:.:..|:|.. :|...|...|....|.|....|.|.|.::..|..:|:||:::
Human   196 GNKDFLPKTSFKKFIGSKLCPLQIFDKICLNILFMMFGYDPKNLNMSRLDVYFSHNPAGTSVQNM 260

  Fly   295 EHYGQQIHSGGFFKYNYYSTWENRRNHGVDTPPQYKLTNVDCKVALYYSRNDRLTSDKDVVRLRD 359
            .|:.|.::|.....|::.|...|..::...|.|.|.:||::...|::..::|.|...:||    :
Human   261 LHWSQLLNSTHLKAYDWGSPDLNLVHYNQTTSPLYNMTNMNVATAIWNGKSDLLADPEDV----N 321

  Fly   360 ILPNVVLDYMFPDPL--YNHINFIWGNDVKTVLNDRMIELMRKVDN 403
            ||.:.:.::::...:  ||||:.::|.||...:...:|::::  ||
Human   322 ILHSEITNHIYYKTISYYNHIDSLFGLDVYDQVYHEIIDIIQ--DN 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18302	NP_609420.1	PLN02872	13..399	CDD:215470	125/365 (34%)
		Abhydro_lipase	43..97	CDD:282003	21/59 (36%)
		Abhydrolase_5	79..>208	CDD:289465	61/130 (47%)
LIPJ	NP_001010939.2	Abhydro_lipase	3..66	CDD:282003	21/59 (36%)
		Abhydrolase_5	47..209	CDD:289465	71/166 (43%)
		Abhydrolase_1	48..347	CDD:278959	106/307 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141823
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	271	1.000	Inparanoid score	I3005
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11005
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.910