DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18301 and TGL1

DIOPT Version :9

Sequence 1:	NP_609419.1	Gene:	CG18301 / 34451	FlyBaseID:	FBgn0032265	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_012782.1	Gene:	TGL1 / 853717	SGDID:	S000001623	Length:	548	Species:	Saccharomyces cerevisiae

Alignment Length:	431	Identity:	115/431 - (26%)
Similarity:	188/431 - (43%)	Gaps:	62/431 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LFQLEANAFFNPFQLAIPSSVLEDAHLNTI-----------QLISKYGYPAENYTVQSDDGYLLG 71
            :.:|......|.|:..|..|...|.  |||           ::.:.:....|::.|:::|.|:|.
Yeast    29 VLKLIPQPMINLFEWLINFSTSSDD--NTIEEKLRSAPTIHEMCAIFDISVEDHLVRTEDNYILT 91

  Fly    72 LFRIA-----RPGALPVLLVHGLMDSSDTWVM-MGPSSSLGYMLYEQGYDVWMANVRGNTYTKRH 130
            |.||.     |.....|.|.|||:..||.|.. :....:|.::|::.||||||.|.|||.|:..|
Yeast    92 LHRIPPISKNRFNNKVVYLHHGLLMCSDVWCCNIERHKNLPFVLHDLGYDVWMGNNRGNKYSTAH 156

  Fly   131 VRYSAEDSDFWNFSFHEMGIFDLPAIIDYILMQSGFGQLHYIGHSQGSTIFWILASERPEYMEKI 195
            :....:.:.||:||..|...||:|..|::||..:...::..||.||||...:...|...:...|:
Yeast   157 LNKPPKSNKFWDFSIDEFAFFDIPNSIEFILDITKVDKVICIGFSQGSAQMFAAFSLSEKLNRKV 221

  Fly   196 VMMQALAPVAFLSHCRSPIVNLLASQDTAVASFLSAAGYNEFLPSNSVIDQFKRY-----ACRDI 255
            ....|:||........:.||:.||..........  .|....||| :||.|...:     .|.||
Yeast   222 SHFIAIAPAMTPKGLHNRIVDTLAKSSPGFMYLF--FGRKIVLPS-AVIWQRTLHPTLFNLCIDI 283

  Fly   256 ISSSVCQSLFFILFGFNGQQVNQTMLPIVVGHTPAGASIRQMHHYGQLRNSGKFQQFDY--GLLN 318
            .:.        |||.:....:.............:..|::.:.|:.|:..|.|||.|:.  .:||
Yeast   284 ANK--------ILFNWKSFNILPRQKIASYAKLYSTTSVKSIVHWFQILRSQKFQMFEESDNMLN 340

  Fly   319 FLHYGSLSPPPYEL------EKVKAKVAIYYAKNDWIAPPEDVDMLFNRLP-NVVEKYLVPNENF 376
            .|      ..||::      ..:|..:.:.|...|.:.   |:|::...|| |.|  :.|..:|:
Yeast   341 SL------TRPYQIANFPTRTNIKIPILLIYGGIDSLV---DIDVMKKNLPFNSV--FDVKVDNY 394

  Fly   377 NHFDLVWGRDAKRILWNRMLGVMQSVVPYSSYNDGD-SITT 416
            .|.||:||:||..::..::|..::      .:|.|: |:.|
Yeast   395 EHLDLIWGKDADTLVIAKVLRFIE------FFNPGNVSVKT 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18301	NP_609419.1	Abhydro_lipase	46..100	CDD:282003	19/70 (27%)
		PLN02872	48..407	CDD:215470	102/378 (27%)
		Abhydrolase_5	82..225	CDD:289465	48/143 (34%)
		Abhydrolase_5	<327..379	CDD:289465	13/58 (22%)
TGL1	NP_012782.1	Abhydro_lipase	66..124	CDD:397965	17/57 (30%)
TGL1	NP_012782.1	Abhydrolase_1	106..402	CDD:395444	88/317 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	108	1.000	Domainoid score	I1418
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	139	1.000	Inparanoid score	I1188
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55134
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	1	1.000	-	-		otm46497
orthoMCL	1	0.900	-	-		OOG6_100408
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X80
TreeFam	0	0.000	Not matched by this tool.
	10	9.770