DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18301 and LIPK

DIOPT Version :9

Sequence 1:	NP_609419.1	Gene:	CG18301 / 34451	FlyBaseID:	FBgn0032265	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	XP_011538375.1	Gene:	LIPK / 643414	HGNCID:	23444	Length:	419	Species:	Homo sapiens

Alignment Length:	371	Identity:	133/371 - (35%)
Similarity:	217/371 - (58%)	Gaps:	17/371 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 DAHLNTIQLISKYGYPAENYTVQSDDGYLLGLFRIARPGALP--------VLLVHGLMDSSDTWV 97
            :|::|..|:||.:|||.|.|.|.:.|||:||::||......|        |.|.|||:.|:..|:
Human    50 EANMNISQIISYWGYPYEEYDVTTKDGYILGIYRIPHGRGCPGRTAPKPAVYLQHGLIASASNWI 114

  Fly    98 MMGPSSSLGYMLYEQGYDVWMANVRGNTYTKRHVRYSAEDSDFWNFSFHEMGIFDLPAIIDYILM 162
            ...|::||.::|.:.|||||:.|.||||::::|::.|.:..::|.||..||..:||||.|::|:.
Human   115 CNLPNNSLAFLLADSGYDVWLGNSRGNTWSRKHLKLSPKSPEYWAFSLDEMAKYDLPATINFIIE 179

  Fly   163 QSGFGQLHYIGHSQGSTIFWILASERPEYMEKIVMMQALAPVAFLSHCRSPIVNLLASQDTAVAS 227
            ::|..:|:|:|||||:||.:|..|..||..:||.:..|||||..:.:.:||:..|.......|..
Human   180 KTGQKRLYYVGHSQGTTIAFIAFSTNPELAKKIKIFFALAPVVTVKYTQSPMKKLTTLSRRVVKV 244

  Fly   228 FLSAAGYNEFLPSNSVIDQF-KRYACRDIISSSVCQSLFFILFGFNGQQVNQTMLPIVVGHTPAG 291
            ..   |...|.| :::.||| ....|...:...:|.:..|.|.||:.|.:|.:.|.:.:.|.|||
Human   245 LF---GDKMFHP-HTLFDQFIATKVCNRKLFRRICSNFLFTLSGFDPQNLNMSRLDVYLSHNPAG 305

  Fly   292 ASIRQMHHYGQLRNSGKFQQFDYGL--LNFLHYGSLSPPPYELEKVKAKVAIYYAKNDWIAPPED 354
            .|::.|.|:.|..|||:.|.||:|.  .|.:|:..|:||.|.:.|::...||:....|.:|.|:|
Human   306 TSVQNMLHWAQAVNSGQLQAFDWGNSDQNMMHFHQLTPPLYNITKMEVPTAIWNGGQDIVADPKD 370

  Fly   355 VDMLFNRLPNVVEKYLVPNENFNHFDLVWGRDAKRILWNRMLGVMQ 400
            |:.|..::.|::...|:|  ::||.|...|.||.:.::..::.:|:
Human   371 VENLLPQIANLIYYKLIP--HYNHVDFYLGEDAPQEIYQDLIILME 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18301	NP_609419.1	Abhydro_lipase	46..100	CDD:282003	24/61 (39%)
		PLN02872	48..407	CDD:215470	131/364 (36%)
		Abhydrolase_5	82..225	CDD:289465	59/150 (39%)
		Abhydrolase_5	<327..379	CDD:289465	16/51 (31%)
LIPK	XP_011538375.1	PLN02872	31..410	CDD:215470	132/365 (36%)
		Abhydro_lipase	55..117	CDD:282003	24/61 (39%)
		Abhydrolase_5	99..>246	CDD:289465	59/146 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141845
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	271	1.000	Inparanoid score	I3005
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	1	1.000	-	-		mtm8502
orthoMCL	1	0.900	-	-		OOG6_100408
Panther	1	1.100	-	-	O	PTHR11005
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.810