DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18301 and SPBC14C8.15

DIOPT Version :9

Sequence 1:	NP_609419.1	Gene:	CG18301 / 34451	FlyBaseID:	FBgn0032265	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_595918.1	Gene:	SPBC14C8.15 / 2539842	PomBaseID:	SPBC14C8.15	Length:	460	Species:	Schizosaccharomyces pombe

Alignment Length:	425	Identity:	114/425 - (26%)
Similarity:	201/425 - (47%)	Gaps:	82/425 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 IWTFFLGLFQLEANAFFNPFQLAIPSSVLEDAHLNTIQLISKYGYPAENYTVQSDDGYLLGLFRI 75
            ::::||....::.||           :.|.||. :||.|.:.:||..|.:.|::.|||||||.|:
pombe    52 VYSYFLPELLVDDNA-----------NKLTDAR-DTIDLCALHGYDLEEHFVRTTDGYLLGLHRV 104

  Fly    76 --ARPGAL-------PVLLVHGLMDSSDTWVM-MGPSSSLGYMLYEQGYDVWMANVRGNTYTKRH 130
              .:.|.:       |||.:||||.:|::||. :....::.:.|.|||||||:.|:|||.|:.::
pombe   105 YKKKKGKIEELNYLPPVLFIHGLMMNSESWVCNLKKEDAIPFALVEQGYDVWLGNLRGNKYSIKN 169

  Fly   131 VRYSAEDSDFWNFSFHEMGIFDLPAIIDYILMQSGFGQLHYIGHSQGSTIFWILASERPEYMEKI 195
            :::|:::..||:||...:.|||:|:|:.|||..:.|..:..:|.|||:.:.:...|...|....:
pombe   170 IKFSSQNPKFWDFSLDSIAIFDIPSIVKYILSVNSFDSISLVGFSQGAILAFAALSIDTELRNSV 234

  Fly   196 VMMQALAP-----------VAFLSHCRSPIVNLLASQDTAVAS--FLSAAGYNEFLPSNSVIDQF 247
            ....||||           |..:.|..|.::.|:..:::.:.|  |..|..|.....  .::|.|
pombe   235 RAFIALAPAIAPKKYSGRTVKSIIHANSQLLYLMFGRNSMLGSAVFWQAVLYPPVFA--KIVDLF 297

  Fly   248 KRYACRDIISSSVCQSLFFILFGFNGQQVNQTMLPIVVGHTPAGASIRQMHHYGQLRNSGKFQQF 312
            .|               ||:  .:.|:.:::|...:...|..:..|::...|:.|:......|.:
pombe   298 LR---------------FFL--SWTGKNISETQKIVAYSHLYSFTSVKCFVHWAQITRRKVLQMY 345

  Fly   313 D---------YGLLNFLHYGSLSPPPYELEKVKAKVAIYYAKNDWIAPPEDVDMLFNRLPNVVEK 368
            |         |..||.:       ..|.:|.::..:.:.|..||.:.   |::.|..:||.:.:.
pombe   346 DDSPGFKPSYYTNLNRI-------ARYPIENIRLPITLVYGSNDNMV---DIETLKTQLPPLSQC 400

  Fly   369 YLVPNENFNHFDLVWGRDAKRILWNRMLGVMQSVV 403
            ..:|  |:.|.|::.|...|.|       |:|.||
pombe   401 IQIP--NYEHLDIIMGDTKKDI-------VIQQVV 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18301	NP_609419.1	Abhydro_lipase	46..100	CDD:282003	26/63 (41%)
		PLN02872	48..407	CDD:215470	105/388 (27%)
		Abhydrolase_5	82..225	CDD:289465	51/154 (33%)
		Abhydrolase_5	<327..379	CDD:289465	11/51 (22%)
SPBC14C8.15	NP_595918.1	Abhydro_lipase	75..138	CDD:282003	26/62 (42%)
		Abhydrolase_1	119..412	CDD:278959	84/323 (26%)
		Abhydrolase_5	120..>260	CDD:289465	48/139 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1188
OMA	1	1.010	-	-		QHG55134
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	1	1.000	-	-		mtm9260
orthoMCL	1	0.900	-	-		OOG6_100408
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R16833
SonicParanoid	1	1.000	-	-		X80
TreeFam	0	0.000	Not matched by this tool.
	10	9.800