DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18301 and Lipa

DIOPT Version :9

Sequence 1:	NP_609419.1	Gene:	CG18301 / 34451	FlyBaseID:	FBgn0032265	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_036864.3	Gene:	Lipa / 25055	RGDID:	3008	Length:	397	Species:	Rattus norvegicus

Alignment Length:	375	Identity:	134/375 - (35%)
Similarity:	217/375 - (57%)	Gaps:	15/375 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 SSVLEDAHLNTIQLISKYGYPAENYTVQSDDGYLLGLFRIAR-------PGALPVL-LVHGLMDS 92
            |:|..:|::|..::|..:|||.|.::||:.|||:||:.||..       .|..||: |.||.:..
  Rat    25 SAVDPEANMNVTEIIMHWGYPGEEHSVQTGDGYILGVHRIPHGRKNQFDKGPKPVVYLQHGFLAD 89

  Fly    93 SDTWVMMGPSSSLGYMLYEQGYDVWMANVRGNTYTKRHVRYSAEDSDFWNFSFHEMGIFDLPAII 157
            |..||....::|||::|.:.|:||||.|.||||::::|...|....::|.|||.||..:||||.|
  Rat    90 SSNWVTNIDNNSLGFILADAGFDVWMGNSRGNTWSRKHKTLSVSQDEYWAFSFDEMAKYDLPASI 154

  Fly   158 DYILMQSGFGQLHYIGHSQGSTIFWILASERPEYMEKIVMMQALAPVAFLSHCRSPIVNLLASQD 222
            :|||.::|..||:|:|||||.||.:|..|:.||..:|:.|..|||||..|:....|:|.|....|
  Rat   155 NYILNKTGQEQLYYVGHSQGCTIGFIAFSQMPELAKKVKMFFALAPVLSLNFASGPMVKLGRLPD 219

  Fly   223 TAVASFLSAAGYNEFLPSNSVIDQFKRYACRDIISSSVCQSLFFILFGFNGQQVNQTMLPIVVGH 287
            ..:....   |..:|||.::::.....:.|..:|...:|.::||::.|||.:.:|.:.:.:...|
  Rat   220 LLLEDLF---GQKQFLPQSAMVKWLSTHICTHVIMKELCANIFFLICGFNEKNLNMSRVDVYTTH 281

  Fly   288 TPAGASIRQMHHYGQLRNSGKFQQFDYGL--LNFLHYGSLSPPPYELEKVKAKVAIYYAKNDWIA 350
            .|||.|::.|.|:.|:....|.|.||:|.  .|:.||....||.|.::.::...|::....||:|
  Rat   282 CPAGTSVQNMVHWTQVVKYHKLQAFDWGSSDKNYFHYNQSYPPLYSIKDMQLPTALWSGGKDWLA 346

  Fly   351 PPEDVDMLFNRLPNVVEKYLVPNENFNHFDLVWGRDAKRILWNRMLGVMQ 400
            ...|:::|...:|.:|....:|  .::|.|.:||.||...|:|.::.:|:
  Rat   347 DTSDINILLTEIPTLVYHKNIP--EWDHLDFIWGLDAPWRLYNEVVSLMK 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18301	NP_609419.1	Abhydro_lipase	46..100	CDD:282003	23/61 (38%)
		PLN02872	48..407	CDD:215470	130/363 (36%)
		Abhydrolase_5	82..225	CDD:289465	65/143 (45%)
		Abhydrolase_5	<327..379	CDD:289465	12/51 (24%)
Lipa	NP_036864.3	PLN02872	7..394	CDD:215470	133/373 (36%)
		Abhydro_lipase	35..96	CDD:282003	23/60 (38%)
		Abhydrolase_5	78..>203	CDD:289465	60/124 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335568
Domainoid	1	1.000	43	1.000	Domainoid score	I12047
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2916
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	1	1.000	-	-		mtm8975
orthoMCL	1	0.900	-	-		OOG6_100408
Panther	1	1.100	-	-	O	PTHR11005
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.810