DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lip4 and LIPF

DIOPT Version :9

Sequence 1:	NP_001260356.1	Gene:	Lip4 / 34450	FlyBaseID:	FBgn0032264	Length:	448	Species:	Drosophila melanogaster
Sequence 2:	NP_001185758.1	Gene:	LIPF / 8513	HGNCID:	6622	Length:	408	Species:	Homo sapiens

Alignment Length:	367	Identity:	140/367 - (38%)
Similarity:	212/367 - (57%)	Gaps:	15/367 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 LNTYSLIKKYGYPAENHTLETDDGYILTLHRI-------ARPGATPVL-LVHGLLDSSATWVMMG 139
            :|...:|..:|||.|.:.:.|:|||||.::||       ...|..||: |.||||.|:..|:...
Human    43 MNISQMITYWGYPNEEYEVVTEDGYILEVNRIPYGKKNSGNTGQRPVVFLQHGLLASATNWISNL 107

  Fly   140 PNKGLGYLLYDQGYDVWMANVRGNTYSRKHVKYSTHHAKFWDFTFHEMGKHDIPATMDYILNSTG 204
            ||..|.::|.|.|||||:.|.||||::|:::.||....:||.|:|.||.|:|:|||:|:|:..||
Human   108 PNNSLAFILADAGYDVWLGNSRGNTWARRNLYYSPDSVEFWAFSFDEMAKYDLPATIDFIVKKTG 172

  Fly   205 VSQLHYIGHSQGTVVFWIMASEKPEYMDKIILMQGLAPVAFLKHCRSPVVNFLAEWHLSVSLVLK 269
            ..||||:||||||.:.:|..|..|....:|.....|||||.:|:.:| ::|.|.  .:..||...
Human   173 QKQLHYVGHSQGTTIGFIAFSTNPSLAKRIKTFYALAPVATVKYTKS-LINKLR--FVPQSLFKF 234

  Fly   270 LIGVHEFLPKNEFISMFNRIICDETTITKEICSNVIFLTTGFDKLQLNETMLPVIVGHSPAGAST 334
            :.|...|.|.|.|.......:|....:.. :|||.:|:..|||....|.:.|.|.:.|:|||.|.
Human   235 IFGDKIFYPHNFFDQFLATEVCSREMLNL-LCSNALFIICGFDSKNFNTSRLDVYLSHNPAGTSV 298

  Fly   335 KQMQHFGQLNRSGGFRQYDHGW-LRNHWIYGTIDPPSYHLENVRAKVALYYGQNDWLAPPEDVEM 398
            :.|.|:.|..:||.|:.||.|. ::|...|....||.|::..:...:|::.|..|.||.|:||.:
Human   299 QNMFHWTQAVKSGKFQAYDWGSPVQNRMHYDQSQPPYYNVTAMNVPIAVWNGGKDLLADPQDVGL 363

  Fly   399 LNRKLPNVVEKYLVDDKEFNHLDFIWGIDARELLWDRMLEIM 440
            |..||||::  |..:...:|||||||.:||.:.:::.::.::
Human   364 LLPKLPNLI--YHKEIPFYNHLDFIWAMDAPQEVYNDIVSMI 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lip4	NP_001260356.1	PLN02872	88..446	CDD:215470	139/362 (38%)
		Abhydro_lipase	88..139	CDD:282003	23/58 (40%)
		Abhydrolase_5	121..>253	CDD:289465	63/132 (48%)
		Abhydrolase_5	<368..419	CDD:289465	17/50 (34%)
LIPF	NP_001185758.1	PLN02872	14..400	CDD:215470	140/362 (39%)
		Abhydro_lipase	45..107	CDD:282003	23/61 (38%)
		Abhydrolase_5	88..>211	CDD:289465	58/122 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141804
Domainoid	1	1.000	45	1.000	Domainoid score	I12200
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	271	1.000	Inparanoid score	I3005
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	1	1.000	-	-		mtm8502
orthoMCL	1	0.900	-	-		OOG6_100408
Panther	1	1.100	-	-	O	PTHR11005
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1506
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.840