DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lip4 and LIPN

DIOPT Version :9

Sequence 1:	NP_001260356.1	Gene:	Lip4 / 34450	FlyBaseID:	FBgn0032264	Length:	448	Species:	Drosophila melanogaster
Sequence 2:	NP_001095939.1	Gene:	LIPN / 643418	HGNCID:	23452	Length:	398	Species:	Homo sapiens

Alignment Length:	386	Identity:	137/386 - (35%)
Similarity:	207/386 - (53%)	Gaps:	27/386 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 LENDVDPNIQEDSHLNTYSLIKKYGYPAENHTLETDDGYILTLHRI------AR-PGATPVL-LV 125
            |||:|:|.:    .:||..:|...|||:|.:.:.|:|||||.::||      || .|..||: :.
Human    24 LENEVNPEV----WMNTSEIIIYNGYPSEEYEVTTEDGYILLVNRIPYGRTHARSTGPRPVVYMQ 84

  Fly   126 HGLLDSSATWVMMGPNKGLGYLLYDQGYDVWMANVRGNTYSRKHVKYSTHHAKFWDFTFHEMGKH 190
            |.|...:|.|:....|..||:||.|.||||||.|.||||:||:|...|....|||.|:|.||.|:
Human    85 HALFADNAYWLENYANGSLGFLLADAGYDVWMGNSRGNTWSRRHKTLSETDEKFWAFSFDEMAKY 149

  Fly   191 DIPATMDYILNSTGVSQLHYIGHSQGTVVFWIMASEKPEYMDKIILMQGLAPVAFLKHCRSPVVN 255
            |:|..:|:|:|.||..:|::||||.||.:.::..|..||...:|.:...|.|....|:   |...
Human   150 DLPGVIDFIVNKTGQEKLYFIGHSLGTTIGFVAFSTMPELAQRIKMNFALGPTISFKY---PTGI 211

  Fly   256 FLAEWHLSVSLVLKLIGVHEFLPKNEFISMFNRIICDETTITKEICSNVIFLTTGFDKLQLNETM 320
            |...:.|..|::..:.|...|..:::...:.:..||: ..|...|||..:.|..|.:|..:|::.
Human   212 FTRFFLLPNSIIKAVFGTKGFFLEDKKTKIASTKICN-NKILWLICSEFMSLWAGSNKKNMNQSR 275

  Fly   321 LPVIVGHSPAGASTKQMQHFGQLNRSGGFRQYDHG-WLRNHWIYGTIDPPSYHLENVRAKVALYY 384
            :.|.:.|:|.|:|...:.|..||..|..||.||.| ...|...|....||.|.|..::...|::.
Human   276 MDVYMSHAPTGSSVHNILHIKQLYHSDEFRAYDWGNDADNMKHYNQSHPPIYDLTAMKVPTAIWA 340

  Fly   385 GQNDWLAPPEDVEMLNRKLPNVVE----KYLVDDKEFNHLDFIWGIDARELLWDRMLEIMR 441
            |.:|.|..|:||.   |.||.:..    |.|.|   :||.||:||:||.:.::..::.:|:
Human   341 GGHDVLVTPQDVA---RILPQIKSLHYFKLLPD---WNHFDFVWGLDAPQRMYSEIIALMK 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lip4	NP_001260356.1	PLN02872	88..446	CDD:215470	130/367 (35%)
		Abhydro_lipase	88..139	CDD:282003	22/58 (38%)
		Abhydrolase_5	121..>253	CDD:289465	56/132 (42%)
		Abhydrolase_5	<368..419	CDD:289465	17/54 (31%)
LIPN	NP_001095939.1	Abhydro_lipase	36..97	CDD:282003	23/60 (38%)
		Abhydrolase_1	79..379	CDD:278959	109/309 (35%)
		Abhydrolase	106..>175	CDD:304388	38/68 (56%)
		Abhydrolase	<149..>234	CDD:304388	27/87 (31%)
		Abhydrolase_5	<322..374	CDD:289465	18/57 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141814
Domainoid	1	1.000	45	1.000	Domainoid score	I12200
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	271	1.000	Inparanoid score	I3005
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	1	1.000	-	-		mtm8502
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11005
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.910