DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lip4 and Lipo4

DIOPT Version :9

Sequence 1:	NP_001260356.1	Gene:	Lip4 / 34450	FlyBaseID:	FBgn0032264	Length:	448	Species:	Drosophila melanogaster
Sequence 2:	NP_001310315.1	Gene:	Lipo4 / 628236	MGIID:	3779637	Length:	398	Species:	Mus musculus

Alignment Length:	378	Identity:	138/378 - (36%)
Similarity:	220/378 - (58%)	Gaps:	16/378 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 DSHLNTYSLIKKYGYPAENHTLETDDGYILTLHRIAR-----PGATPVLLV---HGLLDSSATWV 136
            ::|:|...:||.:.||:|.:.:.|||||||.::||..     ..:.|.::|   ||||.:...||
Mouse    28 EAHMNVSQIIKHWEYPSEEYEVVTDDGYILPINRIPHGKNNANSSAPKMVVFCQHGLLATPGAWV 92

  Fly   137 MMGPNKGLGYLLYDQGYDVWMANVRGNTYSRKHVKYSTHHAKFWDFTFHEMGKHDIPATMDYILN 201
            ...|:..|.::|.|.||||||.:.||:|:::|||..:|...:||||:|.:|.|:|:|||:::||:
Mouse    93 SNLPDNSLAFILADAGYDVWMGSSRGSTWAKKHVTLNTDSKEFWDFSFDQMIKYDLPATINFILD 157

  Fly   202 STGVSQLHYIGHSQGTVVFWIMASEKPEYMDKIILMQGLAPVAFLKHCRSPVVNFLAEWHLSVSL 266
            .||..|::||||||||::.....:...:..:||.|...|||:..::|.:. :....:  :|:.:.
Mouse   158 KTGQKQIYYIGHSQGTLIAIGAFATNQKLAEKIKLNILLAPIYSVQHSKG-IARLTS--YLTPTT 219

  Fly   267 VLKLIGVHEFLPKNEFISMFNRIICDETTITKEICSNVIFLTTGFDKLQLNETMLPVIVGHSPAG 331
            :..|.|..|||| ....|.....:||...:|.. |:.:|....|:...|||.:.|.|.|..:.||
Mouse   220 IKVLFGEKEFLP-TVVSSEVGAYVCDINLVTAG-CAAMIGSMGGYSPEQLNMSRLDVYVKLNLAG 282

  Fly   332 ASTKQMQHFGQLNRSGGFRQYDHGWLR-NHWIYGTIDPPSYHLENVRAKVALYYGQNDWLAPPED 395
            .|.|.:.|:.|:.|||..:.||.|... |...|....||.|::|:::...|::.|..|:|:.|||
Mouse   283 TSVKILIHYNQIRRSGILQAYDWGSSSLNMQHYNQTTPPVYNVEDMKVPTAMFTGLKDFLSDPED 347

  Fly   396 VEMLNRKLPNVVEKYLVDDKEFNHLDFIWGIDARELLWDRMLEIMRNHENSII 448
            ||:|..|:.|:.  ||....:|:|.|||||::|||.:.:.:|.|:|.::...|
Mouse   348 VEILKPKIHNLT--YLKTIPDFSHFDFIWGLNAREEVSEEILTILRKYDGDYI 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lip4	NP_001260356.1	PLN02872	88..446	CDD:215470	135/366 (37%)
		Abhydro_lipase	88..139	CDD:282003	22/58 (38%)
		Abhydrolase_5	121..>253	CDD:289465	56/134 (42%)
		Abhydrolase_5	<368..419	CDD:289465	19/50 (38%)
Lipo4	NP_001310315.1	Abhydro_lipase	33..95	CDD:282003	22/61 (36%)
Lipo4	NP_001310315.1	Abhydrolase_1	77..375	CDD:278959	112/304 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831864
Domainoid	1	1.000	104	1.000	Domainoid score	I6695
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	278	1.000	Inparanoid score	I2905
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	1	1.000	-	-		mtm8736
orthoMCL	1	0.900	-	-		OOG6_100408
Panther	1	1.100	-	-	O	PTHR11005
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910